The invention discloses a milk breaking powder medium-sized grain milk replacer for piglets. The milk replacer comprises a mixed milk replacer material, a high-temperature pretreatment material, a normal-temperature first premix, a normal-temperature second premix and low-protein whey powder in a mixing ratio of (6-14): (4-8): (0.8-2.8): (0.6-1.4): (0.6-1.4), wherein the mixed milk replacer material is composed of the high-temperature pretreatment material, the normal-temperature first premix, the normal-temperature second premix and the low-protein whey powder in a ratio of 6:2:1: 1. The milkreplacer also comprises additives and probiotics. By adopting the secondary granulation technique, the primary granulation temperature is 90 DEG C or above, and the antigen can be maximally eliminated, thereby enhancing the palatability and digestibility of the feed, further enhancing the feed intake of the piglets and ensuring the growth efficiency of the piglets. By adopting the composite micro-ecology, Clostridium butyricum and other probiotics, the milk replacer can protect the intestinal tracts of the piglets, kill harmful bacteria, protect the intestinal health of the piglets and lowerthe morbidity of the piglets, thereby enhancing the survival rate of the piglets.