The invention discloses a lock bead type vibration isolation bumper without harmonic peaks in three directions. The lock bead type vibration isolation bumper without the harmonic peaks in the three directions comprises an outer shell, a top cap, a spring nut, a vibration isolation spring and a ball locking-up mechanism. The lock bead type vibration isolation bumper without the harmonic peaks in the three directions adopts the ball locking-up mechanism, is matched with a locking force adjusting component, an equilibrium position adjusting component and a buffering component, and achieves the purpose of buffering in the three directions of a vibration isolator, vibration isolation without harmonic peaks in the three directions, adjustment of locking force, and meeting different nominal loads. Due to the fact that rolling friction is adopted to isolate vibration, the damping coefficient of the vibration isolator is reduced, and the abrasion in use is reduced. The vibration isolator of the lock bead type vibration isolation bumper without the harmonic peaks in the three directions is enabled to have the advantages of being long in service life, abrasion-resistant, and stable in performance, have high-efficient and high-frequent vibration isolation capability and the like.