The invention belongs to the technical field of chemical adhesives, and relates to a polyurethane moisture-curable hot-melt edge sealing adhesive and a preparation method thereof. Based on weight part, the polyurethane moisture-curable hot-melt edge sealing adhesive comprises the following components: a polyester polyol mixture, diphenylmethyl diisocyanate, a plasticizer, a chain extender and a tackifying resin, wherein the polyester polyol mixture has the relative molecular weight of 1,000-7,000 and is one or more of PHL-1600, PH-2000, CMA-1044 and CMA-44; and the polyurethane moisture-curable hot-melt edge sealing adhesive does not contain any organic solvent, has the solid content of 100 percent, is short in positioning time, quickly and accurately adhere between a decorative film and a to-be-decorated base material, has high adhesive strength and high peel strength, can prevent the influence of water and other adverse environmental factors, has a flexible and elastic adhesive layer and can resist mechanical impact of edge parts in the subsequent polishing decoration process.