The invention discloses a rolling method of an X80 pipeline steel plate. Steel comprises the following chemical components including, by mass, 0.03%-0.08% of C, 1.40%-1.7% of Mn, less than or equal to0.001% of S, less than or equal to 0.01% of P, 0.015%-0.25% of Si, less than or equal to 0.1% of Nb, less than or equal to 0.04% of V, 0.015%-0.03% of Ti, 0.025%-0.06% of Alt, 0.6%-1.0% of Mo+Ni+Cu+Cr and the balance Fe and inevitable impurity elements. A key process comprises heating and rolling. According to the method, the chemical component design concept of compounding microalloy elements such as low carbon, low sulfur, low silicon, low phosphorus, Mo+Ni+Cu+Cr and the like is adopted, temperature gradient rolling is adopted for rough rolling, low-temperature high-pressure rolling is adopted for finish rolling, and a three-stage cooling manner is adopted for cooling after rolling, so that a pipeline steel plate which mainly comprises QF+BF and has a small amount of MA is produced. According to the pipeline steel plate, dispersed distribution is adopted, the grain size reaches 11 grades to 12 grades, the pipeline steel plate is of a microstructure with uniform structure sizes at different positions in the thickness direction, the yield strength is 500 Mpa-550 Mpa, the DWTT single value is larger than or equal to 70% at the experimental temperature of -20 DEG C, the average value is larger than or equal to 85%, the thickness is 38.5 mm, the width is 4336 mm, the steel grade is X80, and the low-temperature (-20 DEG C) crack arrest performance is excellent.