48 results about "Raised tumour" patented technology

The present invention relates to resector balloons (1) employed in treating endoluminal-endobronchial tumoral lesions and endovascular occlusions encountered in blood vessels and in other hollow tube-like organs (7), such as trachea, windpipe, food pipe, urinary tract, bile ducts. Said resector balloon (1) is composed of a resection tip (2); a resection part (3) that is swollen or inflated in such tube-like organs (7) and is displaced or moved back and forth therein to provide tumor resection; a hardening surface (4) provided on the outer surface of said resection part (3) to shave and destroy such tumoral tissues; a catheter section (5) providing access to an endoluminal site; and an injection terminal (6) capable to inflate said resection part (3) by injecting air or fluid.

A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.

An improved method of inducing whole-body hyperthermia and enhanced anti-tumor immune response through inoculation of a fever virus with nil mortality and subsequent injection of irradiated tumor cells derived from the patient. This therapy will safely reduce the tumor burden by 90-99.9% by physical means (fever), before raising interferon levels to over 250 times baseline. The Activated Lymphokine Killer cells produced by these high interferon levels are capable of killing any cell expressing viral or tumor antigens, even those which had previously escaped immune surveillance. As a final step in the process, a specific class of Cytotoxic T Lymphocytes programmed to destroy the patient's own cancer cells will be produced by repeated inoculation of irradiated cancer cells harvested from the patient. Through a combination of three methods of therapy never previously integrated into a single regimen, it is logical to state that this therapy has a high probability of completely eradicating cancer cells from the patient. In addition, this therapy provides for life-long immunity to the reoccurrence of the disease.

A health-care food for preventing and treating atherosclerosis, hypercholesterolemia, hyperlipemia, hypertension, coronary heart disease, angina pectoris, tumor, etc, and balancing the functions of organs is prepared from 10 Chinese-medicinal materials including anemarrhena rhizome, ginger, wolfberry fruit, yam, etc.

An anti-cancer composition comprises anti-cancer effective component selected from tyrosine kinase inhibitor and / or bendamustine and slow releasing adjuvant, and can be prepared into slow releasing injection and slow releasing implantable agent. The slow releasing injection also comprises special dissolvant containing suspending agent. The Suspending agent has a viscocity of 100cp-3000cp (at 20deg.C-30deg.C) and is selected from sodium carboxymethylcellulose, and so on. the slow releasing adjuvant is selected from p(LAEG-EOP), p(DAPG-EOP), p(BHET-EOP / TC), p(BHET-EOP / TC), p(BHDPT-EOP / TC), p( BHDPT-EOP / TC), p(CHDM-HOP) or p(CHDM-EOP.Slow releasing injection and implantable agent can keep high medicinal concentration in tumour part through slow releasing for over 60 days after being injected or implanted in or around tumour. The anticancer composition may also be prepared into sustained-release implant. It can reduce systemic toxic reaction of anticancer drugs, and also selectively improve the therapeutic effect of non-operative therapy such as chemotherapy.

The invention relates to a non-linear fusion method for internal and external radiotherapy doses of a cervical cancer. The method comprises: obtaining internal and external irradiation radiotherapy CT images and internal and external irradiation radiotherapy dose distribution of a to-be-detected cervical cancer; on the basis of non-linear image registration, mapping the internal irradiation radiotherapy CT image to the external irradiation radiotherapy CT image to obtain a transformation relationship between the internal and external irradiation radiotherapy CT images of the to-be-detected cervical cancer; according to the transformation relationship between the internal and external irradiation radiotherapy CT images, transforming internal irradiation radiotherapy dose distribution into equivalent external irradiation radiotherapy dose distribution; and carrying out fusion of the equivalent external irradiation radiotherapy dose distribution and external irradiation radiotherapy dose distribution after transformation by image fusion, rebuilding a distribution curve of internal and external radiotherapy doses, and obtaining a total practically subjected dose of a tumor target region of the to-be-detected cervical cancer and surrounding organs at risks during the comprehensive internal and external irradiation radiotherapy process. The non-linear fusion method is applied to an image-guided radiation therapy of a cervical cancer, thereby improving accuracy of radiotherapy dose evaluation.

The invention discloses an application of functionalized nano-selenium in tumor angiogenesis inhibiting and antitumor drugs. The inventor finds that the functionalized nano-selenium not only has an antitumor effect, but also has a tumor angiogenesis inhibiting effect, so that the functionalized nano-selenium can be used as an active component to be applied in tumor angiogenesis inhibiting and antitumor drugs. The functionalized nano-selenium prepared in the invention, such as heteropoly acid-transferrin modified nano-selenium or gallic acid-transferrin modified nano-selenium, is prepared by directly coupling excessive heteropoly acid or gallic acid with elemental nano-selenium, the preparation process dispenses with addition of other auxiliary reagents, the product system is simple, and the product can be directly preserved and used. The modifier adopted in the invention improves the targeting property and the transport and transmembrane absorption in cells of the functionalized nano-selenium, and can increase the drug intake of cells and reduce drug efflux, thereby guaranteeing that the drug in the cells is maintained at a higher level.

The invention provides a food composition for tumor patients. The food composition consists of poria cocos, colla corii asini, dark plum, galangal, radix angelicae, peach kernel, liquorice, barbary wolfberry fruit, glossy privet fruit, lily, rhizoma polygonati, radix polygonati officinalis, Chinese yam, colla corii asini, longan aril, semen armeniacae amarae, Chinese date, hawthorn, clove, dandelion, sea cucumber, bean pulp and nutrient supplement selenium, wherein each component contains a plurality of anticancer factors with different functions; several components further have the effects of reducing blood pressure, blood sugar and blood fat. Except for the conventional nutrients and the plurality of anticancer factors of protein, fatty acid, polysaccharide, dietary fiber, mineral substance and vitamin, the food composition further contains a plurality of components with such pharmacologic actions as qi supplement, blood replenishment, stomach invigoration, spleen protection, spleen and stomach warming, cold dispelling, damp clearing, diuresis promotion, cough relieving, sputum reduction, adverse-rising energy calming, vomiting prevention, heat clearing and poison removal. The food composition for the tumor patients can exert the synergic effect of the anticancer factors in all the components to the greatest degree through the reasonable composition so as to help the tumor patients to prevent and resist cancers, and can comprehensively satisfy the dietary therapy demands and recovery conditioning of the tumor patients. All the selected components are edible materials without toxic or side effects on human bodies, and can be eaten for a long time.

The invention provides a preparation method for a tumour prosthesis of an upper middle tibia. The method comprises the steps that firstly, a three-dimensional reconstruction technology is adopted to reconstruct uninjured and affected side tibias, according to the tumor position, an osteotomy range is determined, a tibia prosthesis body is obtained through mirroring based on the uninjured side tibia, side wing steel plates and intramedullary nails which are arranged at two sides of sclerotin are fixed to two ends of the tibia prosthesis body through the computer aided design, and an STL model is exported for 3D printing and subsequent treatment. The preparation method is simple and quick and makes up for deficiency of an existing clinical tumour prosthesis of the upper middle tibia, based on the preparation method, the prepared prosthesis reserves the articular surface, the designed bone block fixing steel plate position of the articular surface keeps away from pes anserinus and other parts covered by nervus nerve soft tissues, the fixing is safer and more reliable, a far-end intramedullary nail adopts the combination technology of sliding holes and static holes, and the nail placing position is obtained through the finite element analysis technology, so that the overall mechanics distribution is more uniform after prosthesis implantation, and the long-term stability is reinforced.

The present invention discloses a rectum and vagina intracavity after-loading radiation treatment radiator which comprises an external pipe one end of which is a circular arc surface while the other end is provided with a closing cap. The intracavity of the external pipe is provided with a radiator duct which is used to discharge radiation source. The intracavity of the external pipe is provided with three radiator ducts in the direction of shaft. The three radiator ducts are eccentricly arranged in a semi-circle on the cross section of the external pipe, and are distributed separately along a semi-circle arc curve. The radian between two adjacent radiator ducts is ranged from 40 to80 degrees. The end in same direction of the three radiator ducts is sealed at the end of external port by the closing cap and stretches outward. The present invention can discharge the radiation source through the three radiator ducts which are arranged eccentricly, can debase the irradiation amount accepted by the normal mucous membrane organization near the tumor in the rectum and vagina and the posterior wall of the bladder, can reduce the incidence rate of radioactivity complicating disease in early days and can improve radiation treatment effect.

A drug for treating hydrocrania, brain abscess and cerebroma. It contains: dahurian angelica 25-30íótrichosanthes root 15-20íóalisma rhizome 25-30íójapanese sea tangle 10-15íósargassum seaweed 10-15íówhite tuckahoe25-30íóscutellarta root 15-18íófineleaf schizonepeta 10-15íócimicifuga rhizome 15-20íórhizome of Sichuan lovage 15-20íócorktree bark 10-25íóchinese angelica root-tip 10-15íósichuan aconite root 10-35íócassia twig15-20íóhairy deerhorn 10-15íóhippocampi 15-20íóbezoar 1-3íómusk 0.1 and so on. The preparation method comprises: soaking scutellarta root with wine, soaking sichuan aconite root with vinega, stirring and frying corktree bark, pulverizing the above-mentioned components, mixing with musk and encasing into O-type capsules ( 0.5g per capsule).

The invention discloses an application with hibiscus peel acetic acid to evoke tumor cell to die, which is characterized by the following: extracting effective element of hibiscus peel acetic acid from hibiscus peel; using hibiscus peel acetic acid to antimycotics haemostasis, nerve dermitis and so on aspects; unknowing making mechanism of hibiscus peel; restricting development of hibiscus peel . This invention can resolve the above problems.

The invention relates to a method for preventing and treating tumors by using a microRNA sponge technology. Specifically, activation of canonical and non-canonical NFkappaB pathways can be regulated through a RelA factor, thereby regulating and controlling tumor growth. According to the invention, microRNA sponge miR-221 / 222 is a RelA gene inhibitor which can substantially reduce colorectal cancer cell proliferation and in vivo tumorigenesis; miR-221 / 222 is positively correlated to colorectal cancer cell proliferation and in vivo tumorigenesis, so activation of the canonical and non-canonical NFkappaB pathways can be substantially blocked by inhibiting miR-221 / 222 highly expressed in the colorectal cancer through the microRNA sponge technology; and the RelA factor or a coding sequence thereof can be used as a target point during tumor inhibition, and the RelA factor inhibitor is used for preparing drugs for tumor prevention or treatment.

The invention relates to a head fixing device for tumor radiotherapy. The problems are effectively solved that during common radiotherapy, the height and angle of the head fixing device cannot be adjusted according to the treatment demand of a patient, and the fixing device cannot be adjusted according to the shape and size of the head of the patient. The device comprises a base, a head fixing mechanism is arranged at the upper end of the base, and a supporting rack is arranged at the lower end of the base; a rotation shaft is fixedly connected to the rear end of the supporting rack, and an adjustment mechanism is arranged at the rear end of the rotation shaft, can drive the rotation shaft to rotate around the axis of the rotation shaft and can also drive the rotation shaft to conduct circumference swing. The head fixing device is novel in structure and ingenious in concept. By means of the head fixing device, the head of the patient is fixed at multiple angles and heights, and the device helps a medical worker to handle a more complex condition. The comfort of the patient and working efficiency of the medical worker are improved.

The invention discloses a pH-response tumor targeted cancer resistant medicine carrier and a preparation method thereof. Polyaspartate (PASP) is used as a raw material, through an amidation reaction,tyrosine (Tyr) is grafted to a polyaspartate side chain, a polyaspartate-tyrosine grafted substance having amphipathicity is formed, and the grafted substance can be self-assembled in a water phase toform a nanometer micelle; and based on the nanometer micelle, through the amidation reaction, ethylenediamine is grafted to a polyaspartate side chain, the ethylenediamine is used as a bridge, hyaluronic acid (HA) is grafted to be used as a target ligand, and target action on cancer cells is given to the micelle. Curcumin is used as a hydrophobic medicine model, doxorubicin hydrochloride is usedas a hydrophilic medicine model, simultaneous loading on two medicines is realized, and besides, the medicine loading rate is high. The medicine carrier has the following advantages that the medicinecarrier can load two kinds of medicines simultaneously, is high in the medicine loading rate, has obvious pH response, has targeting properties on the cancer cells, and is good in biocompatibility, low in cost and simple and convenient to operate.

The invention provides application of berberine in preparing a medicament for preventing and treating rheumatoid arthritis. When the berberine is adopted for animal effectiveness test, results show that the berberine can inhibit clinical morbidity of collagen-induced arthritis, and obviously inhibit serious morbid degree and morbidity. The berberine can downwards regulate tumor necrosis factor alpha, interleukin 17 and interferon gamma in splenocyte supernate, and inhibit the secretion of proinflammatory cytokines TNF-alpha, IFN-gamma and IL-17 so as to prepare the medicament for preventing and treating the rheumatoid arthritis with great clinical application value. The medicament is a medicinal composition prepared from the berberine serving as an active ingredient and conventional pharmaceutical adjuvant, and comprises tablets, dispersible tablets, buccal tablets, orally disintegrating tablet, sustained release tablets, capsules, soft capsules, pills, granules, injection, powder injection or aerosol.

The invention discloses an adjustable auxiliary device for tumor clinical treatment. The adjustable auxiliary device comprises a base; roller wheels are arranged at the lower end of the base; a fixedbox body is installed on the base; a lifting box body is installed at the upper end of the fixed box body; a reversing gearbox is arranged on the base at the inner side of the fixed box body and is provided with threaded columns; each threaded column is connected with the interior of a threaded sleeve seat; the threaded sleeve seats are fixedly connected with the lifting box body; a limiting groove is formed in the upper end of the lifting box body and is internally provided with a rotary column; a fluted disc is arranged on the rotary column and is in mesh connection with a worm and gear gearbox; a lifting seat is internally provided with a first sliding seat; the upper end of a first threaded sliding block is connected with a movable seat; a second threaded sliding block is connected with a bed board. The adjustable auxiliary device for tumor clinical treatment is stable in structure and running, convenient to move and use and easy to operate, and can be matched with tumor treatmentequipment for use; the adjustable auxiliary device is convenient to adjust, the height and rotation of the adjustable auxiliary device can be adjusted, and the horizontal and vertical adjustment of the adjustable auxiliary device can be realized along the horizontal direction, so that the adjustment requirements of different treatment devices can be met, and the existing operating requirements canbe met.

The present invention relates to medicine and more particularly to neurosurgery, and can be used in the operative treatment of patients with parasagittal meningiomas. The present invention is directed to the provision of radical removal of a parasagittal meningioma, restoring and securing natural blood flow, obviating recurrent parasagittal meningioma. The object is accomplished by that semicircular incisions of the dura mater circumscribing the tumor contour are made toward the base of the upper sagittal sinus, the tumor is removed as a single block together with a segment of the upper sagittal sinus and a portion of the faix cerebri, whereafter the removed segment of the upper sagittal sinus is replaced with an implant prosthesis ensuring physiological blood flow. The prosthesis is a cynlindrical tubular member in which the end parts are provided with smooth, curvilinear, gently sloping bevels made on its internal generating surface or on both internal and external surfaces thereof.

The invention provides a traditional Chinese medicine composition for treating cancer related fatigue of a patient suffering from a malignant tumor. The traditional Chinese medicine composition is prepared from radix astragali, radix codcnopsitis pilosulas or ginseng, roasted rhizoma atractylodis macrocephalae, prepared liquorice roots, radix angelicae sinensis, dried tangerine or orange peel, rhizoma cimicifugae, radix bupleuri, rhodiola rosea roots and hairyvein agrimonia herb and buds. The rhodiola rosea roots have the functions of strengthening the body resistance, benefiting Qi, nourishing blood and resisting fatigue and oxidation; the hairyvein agrimonia herb and buds can treat blood trouble, cough and asthma caused by the tumor and has the effects on weakness and shortness of breathdue to chronic disease of the patient, and after the hairyvein agrimonia herb and buds are matched with the rhodiola rosea roots, the treatment effect of relieving fatigue can be achieved. By addingthe radix codcnopsitis pilosulas or the ginseng, the effects of invigorating Qi, strengthening the spleen and tonifying healthy Qi of the human body are achieved; the prepared liquorice roots can treat tireness and weakness; the roasted rhizoma atractylodis macrocephalae can tonify the spleen and clear damp away, make transportation and transformation balanced and make the Qi and blood activated,and when the radix astragali is matched with the roasted rhizoma atractylodis macrocephalae, the spleen Qi can be tonified; when the radix astragali is matched with the radix angelicae sinensis, the effects of tonifying Qi and nourishing blood can be achieved; the rhizoma cimicifugae and the radix bupleuri disperse stagnated liver Qi to relieve depression, the dried tangerine or orange peel regulates Qi-flowing for strengthening the spleen, all the medicine materials are combined to treat the liver and the spleen and tonify the Qi and the blood, the usage of the medicine materials is considerate, and the traditional Chinese medicine composition can treat the cancer related fatigue of the patient suffering from the malignant tumor.

The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.

Belonging to the technical field of pharmaceutical chemistry, the invention discloses a Camellia oleifera Abel saponin compound, its preparation method, application and an antitumor drug prepared from the same. The Camellia oleifera Abel saponin compound has a structure shown as formula I, and has certain inhibiting effect on liver cancer cells, breast cancer cells, melanoma cells and lung cancer cells, also can effectively inhibit the liver tumor growth. Thus, the Camellia oleifera Abel saponin compound has significant antitumor activity, and can be used for preparing anti-tumor drugs.

The tumor-enclosed anti-diffusion ablation device of the present invention belongs to the technical field of medical devices. The technical solution of the present invention is: a tumor-enclosed anti-diffusion ablation device, comprising a tumor-enclosed anti-diffusion ablation device main body and a local ablation device, and a directional movable shaft is arranged on the main body of the tumor-enclosed anti-diffusion ablation device, and on the directional movable shaft A display panel is provided, and a data display screen is provided on the front side of the display panel, a display power button is provided on the lower side of the data display screen, and function keys are provided on the front side of the directional movable shaft. The beneficial effects of the present invention are: complete functions, easy to use, time-saving and labor-saving, scientific and convenient, safe and efficient, complete functions, and lightening the work difficulty of medical staff when performing closed anti-diffusion ablation treatment for oncology patients.

The invention discloses a device for draining necrotic tissues after tumor microwave ablation. The device comprises a containing cylinder, a motor and a plurality of drainage mechanisms, wherein a supporting plate is arranged on the inner wall of the containing cylinder; a bottom plate which is rotatably connected to the containing cylinder is arranged below the containing cylinder; a supporting column is arranged on the supporting plate; a fixed plate is arranged at the top of the supporting column; a magnetic attraction mechanism which is used for adjusting the size of magnetic force is arranged on the periphery of the fixed plate; a plurality of movable mechanisms are uniformly arranged on the outer wall of the containing cylinder; the drainage mechanisms are arranged on the movable mechanisms; a reset mechanism is arranged in each movable mechanism; a magnet is arranged on the reset mechanism; the magnetic attraction mechanism is mutually attracted with the magnet; a plurality of the output end of the motor is provided with a plurality of a plurality of connecting rods; the connecting rods are connected to the inner wall of the containing cylinder; an ablation needle; each drainage mechanism is provided with ablation needles; and the drainage mechanisms are connected to the bottom plate through ropes. The ablation needles of the device can adjust the puncture angle and adapt to tumor ablation work of different sizes and shapes.

The invention belongs to the technical field of medicines. The invention provides novel application of wild rose glycoside, in particularly application of the wild rose glycoside to preparation of medicines for reducing toxic and side effects of cytotoxic chemotherapeutic medicines. Experiments show that the wild rose glycoside can improve the cell viability of cytotoxic chemotherapeutic medicine-damaged cells, improve the cell morphology of the cytotoxic chemotherapeutic medicine-damaged cells, and improve organ damage caused by the cytotoxic chemotherapeutic medicines; meanwhile, after combined use of the wild rose glycoside and the cytotoxic chemotherapeutic medicines, the antitumor medicinal effects of the cytotoxic chemotherapeutic medicines are not weakened. Experiments indicate thatthe wild rose glycoside can reduce the toxic and side effects of the cytotoxic chemotherapeutic medicines, improve tolerance of tumor patients to chemotherapy, improve the life quality of the tumor patients, enhance the physique and prolong the lifetime.

The invention relates to an oral spray used for cancer patients, and relates to the technical field of oral care. The oral spray is prepared from the following components in percentage by weight: 2% to 15% of a sugar alcohol humectant, 2% to 16% of a forsythia fruit extract, 2% to 10% of a stevia rebaudianum extract, 2% to 10% of a propolis extract, 1% to 10% of a blueberry extract, 0.2% to 10% of a solubilizer, 0.2% to 2% of thymol crystals, 0.7% to 10% of a metal astringent, 0.5% to 5% of a preservative, 0.05% to 4% of guaiazulene sodium sulfonate, 0.1% to 2.5% of poloxamer, 0.7% to 9% of an acidity regulator and the balance of deionized water. The oral spray disclosed by the invention is safe, and free of obvious stimulation or side effect, has the effects of relieving pain, inhibiting bacteria, resisting viruses and eliminating free radicals, and is capable of relieving oral inflammatory reactions caused by chemoradiotherapy, relieving pains caused by oral mucosa damage and promoting oral mucosa repair.

The invention relates to a catheter device and a method thereof for waking up the anesthesia in a brain functional region surgery, comprising a tracheal catheter, an opening is formed on the top of the outer end of the tracheal catheter which is inserted to the esophagus direction, the top part of the inner end is closed, an esophagus closed cuff is arranged in the vicinity of the top part of theinner end, a pharyngeal cavity closed cuff is further arranged on the tracheal catheter; a vent hole is arranged at the part of the tracheal catheter between the esophagus closed cuff and the pharyngeal cavity closed cuff for leading an air duct to be communicated with and a glottis of a trachea; the esophagus closed cuff and the pharyngeal cavity closed cuff are respectively connected with a ventpipe. The catheter device is provided with the esophagus closed cuff and the pharyngeal cavity closed cuff on the tracheal catheter and is provided with the vent hole between the esophagus closed cuff and the pharyngeal cavity closed cuff, so the usage of the catheter device of the invention for carrying out the waking-up of the anesthesia can not only meet the requirements on the precise positioning of the function region, but can also be safe and convenient, and the catheter does not need to be inserted and drawn repeatedly, thus eliminating the risks of excessive injuries of a patient, being able to resect a tumor to the maximum extent and protecting the normal brain tissues of the brain functional region to the utmost extent.

The invention relates to clamping forceps, and particularly discloses clamping forceps used for a tumor. The clamping forceps comprise two clamping ends and are characterized in that the clamping ends are in an arc shape bending inwards, and anti-slipping patterns are arranged on the inner walls of the clamping ends; a tooth rake head is arranged at the end of one clamping end in the direction of facing the other clamping end, and teeth of the tooth rake head are in a flat end, or acute end or blunt end shape. The clamping forceps can prevent the tumor from disengaging, do not destroy the surface of the tumor or damage the blood vessels of the tumor, can provide a clean and broad visual field, and are beneficial for smooth completion of operations.

The present invention relates to methods of treating cancer in which histamine is administered in conjunction with other cancer therapies. The cancer therapy includes surgery, radiation, immunotherapy, the administration of an agent which enhances the humoral immune response of the patient or any combination thereof.

CASB7439 polypeptides and polynucleotides, immunogenic compositions comprising them and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing CASB7439 polypeptides and polynucleotides in diagnostics, and vaccines for prophylactic and therapeutic treatment of cancers, particularly colorectal, breast, and lung cancers, autoimmune diseases, and related conditions.