9 results about "Silver nanorods" patented technology

Provided are a Surface-Enhanced Raman Scattering (SERS) biosensor based on a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) / Cas13a system and an application thereof, belonging to the field of spectroscopy detection. The SERS biosensor includes an SERS sensor chip, a first reagent, a second reagent, a third reagent, and a fourth reagent. The SERS sensor chip is a silver nanorod array substrate with hairpin Deoxyribonucleic Acid (DNA) single-stranded H1 and blocking molecule 6-mercaptoethanol modified on the surface. The first reagent is a SERS probe and buffer of the probe. The second reagent is hairpin nucleic acid aptamer strand MUC1-apt aqueous solution. The third reagent is the CRISPR / Cas13a system and buffer of the system. The fourth reagent is hairpin DNA single-stranded H2 aqueous solution. The above reagents are mixed with the gastric cancer exosomes to be detected and then dripped on a surface of the SERS sensor chip.

A photoelectric conversion element including a thin film composed of a transition metal dichalcogenide and formed on a base material. In the present invention, a surface of the thin film composed of the transition metal dichalcogenide is modified with at least any nanorod particles of Au nanorod particles composed of Au and Ag nanorod particles composed of Ag. An average aspect ratio of the Au nanorod particles is 3.0 or more and 12.0 or less, and an average aspect ratio of the Ag nanorod particles is 3.0 or more and 13.0 or less. In the invention, the sensitivity to light having wavelengths in the near-infrared region improves by a sensitizing action attributed to localized surface plasmon resonance that is developed by the Au and Ag nanorod particles.

The invention belongs to the technical field of materials, and discloses a plasmon all-silver nanocavity for regulating and controlling exciton luminescence of a two-dimensional material and a preparation method of the plasmon all-silver nanocavity. The plasmon all-silver nanocavity comprises a silver micron plate and a silver nanorod loaded on the silver micron plate, and the surface of the silver nanorod is coated with a silicon oxide layer. According to the plasmon all-silver nanocavity, an all-silver framework is adopted, the material advantages of low ohmic loss and large optical cross section of silver in the visible light wave band are fully utilized, and the quality factor and the light field localization capability of the nanocavity are remarkably improved.

The invention discloses a capillary SERS (Surface Enhanced Raman Scattering) sensor based on CRISPR / Cas13a (Clustered Regularly Interspaced Short Palindromic Repeats / CRISPR associated 13a), a preparation method of the capillary SERS sensor and application of the capillary SERS sensor to detection of a hepatocellular carcinoma marker miR-221, the method comprises the following steps: 1) adopting a seed growth method, firstly synthesizing a decahedral gold nano seed, and on the basis, continuing to react and grow to obtain dumbbell-shaped gold and silver nano rods (DS Au-AgNRs); (2) dispersing the DS Au-AgNRs prepared in the step (1) into a PVP ethanol solution, and assembling the DS Au-AgNRs onto an aminated capillary tube by utilizing the interaction of PVP groups on the surfaces of nano-particles and amino groups on the inner wall of the capillary tube, so as to obtain a capillary tube SERS (Surface Enhanced Raman Scattering) substrate; and 3) modifying the surface of the capillary SERS substrate prepared in the step 2) with a single-stranded DNA modified with sulfydryl and Raman signal molecules (Cy5) through a gold-sulfur bond to construct the SERS sensor.The capillary SERS sensor provided by the invention has the advantages of high sensitivity, high specificity, convenience in sampling, low cost and the like, and is expected to provide a novel method with a prospect for early diagnosis of HCC.

This invention discloses a full-cycle photothermal-magnetic responsive intelligent antibacterial system based on silver nanorods combined with mesoporous iron(III) oxide and an antibacterial agent, its preparation method, and its application. Specifically: 1) Silver nanorods (AgNRs) are prepared using a solvothermal method, and used as the core. A mesoporous iron(III) oxide (MesoFe3O4) shell is constructed on their surface using a template method to obtain AgNRs@MesoFe3O4 material; 2) The antibacterial agent is loaded into the material in step 1 using a cyclic ultrasonic impregnation-low temperature air drying process; 3) A PBS solution of the AgNRs@MesoFe3O4 material loaded with the antibacterial agent is prepared, and after treatment, a full-cycle photothermal-magnetic responsive intelligent antibacterial system is obtained. The antibacterial system can achieve biofilm destruction and antibacterial agent release through external magnetic field driving and infrared light dual response. The AgNRs in the antibacterial system maintain a long-term antibacterial environment by slowly releasing silver ions, thus achieving full-cycle antibacterial activity.

Disclosed are an SERS biosensor based on a CRISPR / Cas13a system and use thereof. The SERS biosensor comprises an SERS sensing chip, a first reagent, a second reagent, a third reagent, and a fourth reagent. The SERS sensing chip is a silver nanorod array substrate with a surface modified with a hairpin-type DNA single chain H1 and a closed molecule 6-mercaptohexanol. The first reagent is an SERS probe and a buffer thereof. The second reagent is a hairpin-type nucleic acid aptamer chain MUC1-apt aqueous solution. The third reagent is a CRISPR / Cas13a system and a buffer thereof. The fourth reagent is a hairpin-type DNA single-chain H2 aqueous solution. The reagents and a gastric cancer exosome sample to be detected are mixed and then dropwise added to the surface of the SERS sensing chip, and sensitive and accurate detection of gastric cancer-related exosomes is achieved by means of the CRISPR / Cas13a system, catalytic hairpin assembly, and SERS enhancement performance of the silver nanorod array substrate.

The invention provides a microneedle patch for closed-loop management of drug-resistant bacteria infected wounds of animals as well as a preparation method and application of the microneedle patch. According to the micro-needle patch, silk fibroin / hyaluronic acid composite hydrogel serves as a matrix, silver nanorods with specific local surface plasmon resonance (LSPR) characteristics are loaded, and wound pH real-time monitoring and near-infrared two-zone (NIR-II) photo-thermal sterilization functions based on surface enhanced Raman spectroscopy (SERS) can be achieved. The microneedle structure can penetrate into the deep layer of the wound, and precise delivery and treatment are achieved. According to the invention, monitoring and treatment are integrated, a closed-loop management system is formed, and the diagnosis and treatment efficiency and healing quality of wounds infected by drug-resistant bacteria of animals are remarkably improved. The patch has good wound pH monitoring ability, antibacterial effect and wound healing ability, and an efficient and safe solution is provided for treatment of drug-resistant bacteria wounds of animals.

This invention discloses a multi-responsive self-healing long-lasting coating for magnesium alloy surfaces, its preparation method, and its application, relating to the field of surface modification technology. The method includes a hydrothermal reaction on a magnesium alloy surface to obtain in-situ grown Mg(OH)₂; electrophoretic deposition of polydopamine on the in-situ grown Mg(OH)₂; preparation of silica-encapsulated silver nanorods loaded with dopamine nanoparticles; uniform dispersion of the nanoparticles in a polycaprolactone solution to obtain a polycaprolactone solution containing nanoparticles; and coating the polydopamine with the polycaprolactone solution containing nanoparticles, thus forming a multi-responsive self-healing long-lasting coating on the magnesium alloy surface. This invention constructs an early warning system based on Mg(OH)₂ on the magnesium alloy surface, responding to Mg… 2+ A composite coating with good inorganic-organic bonding achieves durable and stable multi-layer protection through pH and near-infrared light (NIR). This coating not only provides long-lasting corrosion protection but also has de-icing and marine antifouling functions.

This invention discloses a silver nanorod@mesoporous iron(III) oxide composite heterogeneous hydrogel material with bone-promoting and intelligent anti-infection functions, its preparation method, and its application. Specifically: 1) AgNRs are prepared, and a MesoFe3O4 shell is constructed on their surface using a template method to obtain AgNRs@MesoFe3O4; 2) Antibacterial agents are loaded into AgNRs@MesoFe3O4 using cyclic ultrasonic impregnation-low-temperature vacuum drying; 3) A sodium alginate solution containing drug-loaded AgNRs@MesoFe3O4 is poured into the bottom layer of a mold to obtain a nanomaterial layer, and a mixed solution containing AlgMA and sodium alginate is poured into the top layer; 4) UV curing and Ca2+ curing are performed. 2+ The solution impregnation method achieves dual in-situ gelation of the above solution. The solution is impregnated in a solution containing osteogenic drugs, rinsed, dried, and sterilized by irradiation to obtain a heterogeneous hydrogel. This material disrupts biofilms and kills bacteria, exhibiting both antibacterial and osteogenic functions.