The present invention provides a preparation, which comprises a container and a liquid preparation composition accommodated in the container, wherein the liquid preparation composition is an emulsion and comprises a solvent and surfactant-containing liquid droplets distributed in the solvent, the average volume particle size of the liquid droplet is less than or equal to 100 [mu]m, the surface tension of the liquid preparation composition is less than 60 mN/m, the absolute value of the zeta potential is more than or equal to 15 mV, and the container is a sprayer or liquid dropping device. The present invention further discloses a preparation method of the preparation, and uses of the preparation in treatment of otitis media, otitis externa, rhinitis, sinusitis, lower respiratory tract inflammation, xerostomia, xeroma, and dryness in the nasal cavity. According to the present invention, the preparation can relieve otitis media, otitis externa, rhinitis, sinusitis, lower respiratory tract inflammation, xerostomia, xeroma, dryness in the nasal cavity, and other symptoms, can be used in the spray agent or liquid dropping agent form, can be applied without the use of the propellant or atomization device, such that the operation is easy, and the irritation and injury caused by the propellant and the use inconvenience of the atomization device can be avoided.