The invention discloses a mixed cooling low-pressure wheel hub mold. The mixed cooling low-pressure wheel hub mold comprises an upper mold body, a lower mold body and side mold bodies, and the upper mold body, the lower mold body and the two side mold bodies can jointly form a casting mold for casting a wheel hub in an enclosing mode; a wheel rim water cooling mechanism is arranged in each side mold body, each wheel rim water cooling mechanism comprises a flow dividing pipe, an upper flow guiding pipe and a lower flow guiding pipe, and the upper flow guiding pipes and the lower flow guiding pipes communicate with the flow dividing pipes through three-way pipes; and a wheel spoke air cooling mechanism, a wheel spoke water cooling mechanism and a diaphragm medium are arranged in the lower mold body. According to the mixed cooling low-pressure wheel hub mold, the wheel hub mold is cooled by adopting a water cooling and air cooling mixed mode, the cooling speed is high, and the achieved chilling effect is better; and pipe arranging structures in the lower mold body and the side mold bodies are overall planned according to the thickness of all parts of the wheel hub, therefore, the cooling speed of all the parts of the wheel hub is more similar, the wheel hub can be overall molded, and the phenomena that the junctions of wheel spokes and a wheel rim have large shrinkage holes and wheel rim shrinkage defects due to the fact that shrinkage compensation is insufficient are avoided.