The invention belongs to the technical field of burn treatment and discloses a burn powder and a preparation method thereof. The burn powder is composed of indigo naturalis, radix arnebiae, sanguis draxonis, borneolum Syntheticum and Calomelas. Take radix Arnebiae, washing, sun dry, pulverizing into fine powder, sieving with 200 mesh sieve; Grind sanguis Draxonis, borneolum Syntheticum and Calomelas into fine powder, sieve with 200 mesh sieve; Mix the five medicines evenly, sterilize and disinfect them; Put it in a plastic bottle with a 100-mesh mesh mesh mouth. The invention has the effects of clearing away heat and toxic materials, astringing and wounding toxic materials, removing decay and promoting granulation, promoting blood circulation, removing blood stasis, detumescence and analgesia. It is mainly used to treat all kinds of burn and scald, and the burn Powder is suitable for wet burn. The invention provides a Chinese medicine dosage form with definite curative effect, small side effect, wide drug source, low price, convenient use and easy portability for treating burn, which is especially suitable for grass-roots hospitals, opens up a new way for treating burn with traditional Chinese medicine, and is expected to be a novel and effective Chinese medicine product for treating burn and wound, and has wide application prospect.