A nano-diamond modified liquid band aid is prepared from raw materials in parts by weight as follows: 15-20 parts of a film forming material, 10-20 parts of ethyl acetate, 40-50 parts of ethanol, 3-5parts of propylene glycol, 2-6 parts of polydimethylsiloxane, 4-7 parts of medical vaseline, 4-8 parts of a cattail spike extract and 2-4 parts of modified nano-diamond, wherein the film forming material, ethyl acetate, ethanol, propylene glycol, polydimethylsiloxane and the medical vaseline are taken as basic raw materials, the cattail spike extract and the modified nano-diamond are taken as active ingredients, and the sum of parts of the basic raw materials and the cattail spike extract by weight is 100. The invention further discloses a preparation method of the nano-diamond modified liquidband aid. Compared with conventional band aids, the liquid band aid is convenient to use, has good antibacterial and anti-inflammatory functions and has no irritation or toxicity to skin, external wounds in any shape and in any position can be more conveniently treated, and the liquid band aid can rapidly form a film and has the efficacy of stopping bleeding, diminishing inflammation, relieving pain and promoting blood circulation to remove blood stasis.