The invention discloses a production method of 15CrMoR steel plates for equipment in hydrogen service. Steel is prepared from chemical components including, by weight, 0.10%-0.15% of C, 0.16%-0.25% ofSi, 0.42%-0.52% of Mn, less than or equal to 0.010% of P, less than or equal to 0.005% of S, 0.020%-0.050% of Alt, 0.90%-1.10% of Cr, 0.46%-0.56% of Mo, less than or equal to 0.010% of Sn, less thanor equal to 0.012% of As, less than or equal to 0.003% of Sb and the balance Fe and residual elements; and the tempering embrittlement coefficient X is equal to (10P+5Sb+4Sn+As)*10<-2> and is less than or equal to 15 ppm. The production technology process includes smelting in a converter, refinement in an LF, VD vacuum treatment, continuous casting, slab heating, controlled rolling, online coolingand heat treatment. Various actual product quality properties of the products produced with the method are as follows: head and tail samples of the steel plates are subjected to maximum simulated postweld heat treatment, the yield margin at the 1/2-plate-thickness positions of the samples ranges from 40 MPa to 100 MPa, the tensile margin ranges from 50 MPa to 80 MPa, and the low-temperature impact property is stable and large in margin.