The invention relates to a technique for producing anti-acid pipeline steel by RH-LF-VD refining. According to the technique, convertor steel making and RH-LF-VD refining techniques are utilized to control the components of molten steel, thereby producing the low-carbon low-sulfur anti-acid (anti-HIC and anti-SCC) pipeline steel. The technique comprises the following steps: predesulfurizing molten iron, smelting in a convertor, carrying out RH vacuum decarburization, carrying out LF heating for desulfurization, carrying out VD vacuum decarburization, carrying out calcium treatment, carrying out soft blowing, continuously casting, and carrying out hot rolling. By using the secondary vacuum refining processes (RH vacuum refining and VD vacuum refining), the invention can reduce the decarburization load of the convertor, lower the oxidizability of the molten steel, eliminate the adverse effect of carburization in the LF furnace refining process, reduce the consumption of a strong deoxidizer, stabilize the production, ensure that the molten steel components are stably controlled within the production target, and satisfy the component control requirements of low carbon, low sulfur and high purity for anti-acid pipeline steel. The carbon content of the finished steel produced by the technical process provided by the invention can be controlled to 0.03%, and the sulfur content can be stably controlled to at most 0.0010%.