The invention discloses a preparation method of dendrobium nobile decoction pieces. The preparation method comprises the following steps: S1, picking: picking fresh dendrobium nobile from a planting field; S2, cleaning: cleaning and processing the dendrobium nobile picked in the step S1; S3, slicing treatment: slicing the dendrobium nobile cleaned in the step S2; S4, punching treatment: conductingpinhole insertion on the dendrobium nobile subjected to slicing treatment in the step S3; and S5, drying treatment: drying the dendrobium nobile slices punched in the step S4. The invention relates to the technical field of traditional Chinese medicine processing. According to the preparation method of the dendrobium nobile decoction pieces, a punching treatment process is adopted, the pore diameter of dendrobium nobile slices is increased, and the contact surface area of the dendrobium nobile slices and the outside is increased, so that during the drying treatment, the drying efficiency is higher, the energy consumed during drying is reduced, at the same time, during soaking of the dendrobium nobile decoction pieces, the sufficient degree of contact between the surface and drinking wateris increased, brewing is more convenient, medicine properties in the dendrobium nobile slices are easier to soak on the surfaces of the punched holes, and a user can brew and drink the dendrobium nobile slices conveniently.