The invention relates to an unmanned aerial vehicle cleaning device for a glass curtain wall. The unmanned aerial vehicle cleaning device includes an unmanned aerial vehicle, a frame, universal wheels, a side rotor wing, a camera, sprayers, a high pressure water pipe, a power supply line, a high pressure water pump, and a water barrel. The unmanned aerial vehicle adopts a mooring unmanned aerial vehicle technology; the difficult problem of endurance and load can be solved; power and cleaning liquid are supplied from a ground, and the cleaning device has a small capacity battery (the unmanned aerial vehicle is hoisted to cleaning an attic without the battery, and is safer); the unmanned aerial vehicle can safely return to the ground during failure of a power supply; when the unmanned aerial vehicle flies to a designated position, the side rotor wing is started, the pushing force generated by the side rotor wing allows the universal wheels to be attached onto the glass curtain wall all the time; the unmanned aerial vehicle can select horizontal sprayers or longitudinal sprayers to clean the glass curtain wall according to different structures of surfaces of the glass curtain wall; and the sprayers will eject high pressure water mist, the high pressure water pump provides the cleaning liquid to the sprayers, and then the glass curtain wall can be rapidly cleaned. The unmanned aerial vehicle cleaning device is simple in design and structure, is easy to operate, is high in cleaning efficiency, and can avoid potential safety hazards.