32 results about "Congenital disease" patented technology

The invention provides an ibuprofen pharmaceutical composition, wherein ibuprofen concentration is 4.5-5.5mg / ml and tromethamine concentration is 3.6-4.0mg / ml. The invention also provides a preparation method of the ibuprofen pharmaceutical composition, wherein the preparation method comprises the following steps: (1) adding tromethamine, sodium hydroxide and sodium chloride to injection water, stirring until the materials are dissolved and adding ibuprofen; (2) heating and cooling the mixed materials in a circulating mode at least twice, wherein the heating-cooling circulation means to heat the materials from 10-30 DEG C to 40-60 DEG C and then to cool the materials from 40-60 DEG C to 10-30 DEG C; and (3) filtering, filling and sterilizing so as to obtain the ibuprofen pharmaceutical composition. Through the technical scheme, the stability of the ibuprofen pharmaceutical composition is significantly improved.

The invention relates to a method for preparing a teaching specimen of an apical four-chamber view of a stillbirth suffered from a congenital heart disease. The method comprises the following steps: selecting an artificial labored fetus having a malformed heart; antiseptically treating the artificial labored fetus to prepare a free heart specimen, and making the vertical axis of the view parallel to the long axis of the heart and making the horizontal axis of the view parallel to the left-right direction of the heart from the apex of the heart,; and along the direction from the front upper position of 1 to 2 centimeters of left and right edges of the heart to the base of the heart, cutting the heart from the center of the right atrium and a position nearby an orifice of a pulmonary vein of the left atrium. The obtained apical four-chamber view specimen has the advantages of integrated and complete structures of all parts, no damage to microstructures in the heart, the same shape as that in a real living body, and capability of meeting the requirements of medical teaching and practice and the like, and is suitable for schools, hospitals or medical research institutes.

The invention relates to a separated nucleic acid of encoded skeletal muscle chloride ion channel mutants, an isolated polypeptide, a method for screening a myotonia congenital disease susceptible biological sample, a system for screening a myotonia congenital disease susceptible biological sample and a kit for screening a myotonia congenital disease susceptible biological sample. Specifically, the separated nucleic acid of encoded skeletal muscle chloride ion channel mutants, compared with the SEQ ID NO:1, has at least one mutation selected from the following: c.2655_2656insC, c.1616C>T, c.2057_2058delAC and c.313C>T. By detecting the existence of the new mutants in the biological sample, whether the biological sample is susceptible to a myotonia congenital disease can be effectively detected.

The invention provides a blood flow limiter for a congenital heart disease interventional operation. The blood flow limiter comprises a flow limiting structural body and a flow limiting rotating piece. The flow limiting structural body comprises a flow limiting fixed piece and a tubular support frame. A through hole is formed in the flow limiting fixed piece. The flow limiting fixed piece is fixedly connected to one end of the tubular support frame. The size of the flow limiting fixed piece is not smaller than the size of the end face, to which the flow limiting fixed piece is connected, of the tubular support frame. The flow limiting rotating piece is rotatably connected to an end face of the flow limiting fixed piece in such a manner of rotating in one way. The flow limiting rotating piece is rotated to adjust the size of a blood flow passage formed by the flow limiting rotating piece in match with the through hole in the flow limiting fixed piece, thus realizing adjustment of blood flow. The area of the blood through hole can be adjusted from 0 to the maximum area of the through hole in the flow limiting fixed piece, so that the blood flow of pulmonary artery can be adjusted according to actual situations after the operation; and therefore, the optimal treatment effect can be achieved.

The invention discloses a congenital aniridia disease-causing gene, a kit for detecting the congenital aniridia disease-causing gene and an application of the gene. The congenital aniridia disease-causing gene is a mutational PAX6 (Paired box6) gene, one point of a basic group in a 323th site of a sixth exon of the PAX6 gene is muted to A from C, and a genetic codon (TCC) for encoding serine at a 108th site is changed into a genetic codon (TAC) for encoding tyrosine, namely S108Y mutation is caused. The invention also provides a kit used for detecting the congenital aniridia disease-causing gene. The kit used for detecting the congenital aniridia disease-causing gene comprises 2mM dNTPs, 10*PCR (Polymerase Chain Reaction) buffer solution, DNA polymerase, PCR amplification primer pairs and double distilled water, wherein the PCR amplification primer pair is composed of a primer 1 (shown in SEQ ID NO:1) and a primer 2 (shown in SEQ ID NO:2). The invention provides a new congenital aniridia disease-causing gene, so that a new technological means is provided for genetic diagnosis of congenital aniridia, and a foundation is also laid for study of a pathogenetic molecular mechanism.

The invention relates to an apparatus and method for identifying blood vessels in an angiography-assisted congenital heart disease operation. The apparatus comprises a CT image preprocessing module, a segmentation module, a three-dimensional reconstruction module, a two-dimensional planarization module, a contrast imaging module, a registration initialization module, a quantum updating module, an individual mutation module, a mutation post-processing module, an image registration module and a blood vessel identification result display module, wherein the CT image preprocessing module, the segmentation module, the three-dimensional reconstruction module and the two-dimensional planarization module are used before the operation, and the contrast imaging module, the registration initialization module, the quantum updating module, the individual mutation module, the mutation post-processing module, the image registration module and the blood vessel identification result display module are used in the operation. The method includes the following steps that: a preoperative image is segmented; three-dimensional visual reconstruction is performed on segmented CT images, so that segmented two-dimensional images of a preoperative heart and preoperative blood vessels are obtained; and the segmented two-dimensional images of the preoperative heart and preoperative blood vessels are registered with intra-operative contrast images, and results obtained after registration are displayed. With the apparatus and method of the invention adopted, the registration results have high precision and rich detail information, and therefore, the accurate positions of the blood vessels of a patient can be provided for a doctor in a congenital heart disease operation, and the difficulty of the operation can be reduced.

The invention relates to a method for preparing a teaching specimen of a left ventricular outflow tract view of a stillbirth suffered from a congenital heart disease. In the method, a free heart specimen is prepared after a selected artificially-labored fetus having a malformed heart is antiseptically treated; and in the left ventricular outflow tract view, the horizontal axis of the view is parallel to the long axis of the heart by taking a pulmonary conus as a start point of a cross section, the cross section is up to a superior vena cava through aorta ascendens and down to the apex of the heart through an anterior interventricular groove. The obtained apical four-chamber view specimen has the advantages of integrated and complete structures of all parts, no damage to microstructures in the heart, the same shape as that in a real living body, and capability of meeting the requirements of medical teaching and practice and the like, and is suitable for schools, hospitals or medical research institutes.

The invention relates the congenital heart disease plugging device, comprising the bevel support 1 and polyester fibre 2. The bevel support 1 is weaved by the nickel-cemented tantalum carbide, and the diameter of 1 is between 0.002-0.003 inch, the 1 is filled with 2, and around the metal wire of 1 there is polydactyl acid, silica gel, polyurethane or other degradable consistency high polymer materials. The invention has the advantages of reducing heavy metal toxicity, low vessel chronic injury and mechanical stimulation, and safety.