32 results about "Congenital disease" patented technology

The invention relates the congenital heart disease plugging device, comprising the bevel support 1 and polyester fibre 2. The bevel support 1 is weaved by the nickel-cemented tantalum carbide, and the diameter of 1 is between 0.002-0.003 inch, the 1 is filled with 2, and around the metal wire of 1 there is polydactyl acid, silica gel, polyurethane or other degradable consistency high polymer materials. The invention has the advantages of reducing heavy metal toxicity, low vessel chronic injury and mechanical stimulation, and safety.

The invention discloses a surgical conveying device for interventional treatment of congenital heart diseases, which comprises an outer sheathing canal, an inner sheathing canal, a push rod, a hemostatic valve, a loading sheath, a heart-opening combination device and a conveying combination device, wherein the heart-opening combination device is combined by the outer sheathing canal and the inner sheathing canal, and the conveying combination device is combined by the outer sheathing canal, the push rod, the hemostatic valve and the loading sheath. By using the surgical conveying device disclosed by the invention, no X-ray radiography is required in a surgical process, therefore, no radiation damage is caused on doctors and patients.

The invention discloses a multi-channel congenital heart disease rapid screening device and a screening method thereof. The multi-channel congenital heart disease rapid screening device comprises a handheld type gun body, a sleeve, a heart sound sensor array, an environment noise collector, an oxyhemoglobin saturation collecting sensor and a displaying screen. The sleeve is detachably connected toa gun head of the handheld type gun body, the heart sound sensor array is integrated on the front end face of the sleeve, the heart sound sensor array is arranged according to the position where a signal needs to be collected, the environment noise collector is arranged on the side wall of the sleeve, the displaying screen is arranged above a handheld part of the handheld type gun body, the oxyhemoglobin saturation collecting sensor is connected with the handheld type gun body, and an internally-arranged circuit board and a lithium battery are arranged in the handheld type gun body. Comparedwith the prior art, the multi-channel congenital disease rapid screening device and the screening method thereof have the beneficial effects that the detection process of congenital heart disease is simplified to a large extent, rapid collecting and intelligent analysis of heart disease data are achieved, and the rapid screening device is a novel device which can be applied to newborn congenital heart disease screening.

The invention relates to a method for preparing a teaching specimen of a left ventricular outflow tract view of a fetus suffered from a congenital heart disease. In the method, a free heart specimen is prepared after a selected artificially-labored fetus having a malformed heart is antiseptically treated; and in the left ventricular outflow tract view, the horizontal axis of the view is parallel to the long axis of the heart by taking a pulmonary conus as a start point of a cross section, the cross section is up to a superior vena cava through aorta ascendens and down to the apex of the heart through an anterior interventricular groove. The obtained apical four-chamber view specimen has the advantages of integrated and complete structures of all parts, no damage to microstructures in the heart, the same shape as that in a real living body, and capability of meeting the requirements of medical teaching and practice and the like, and is suitable for schools, hospitals or medical research institutes.

The invention discloses an occlusion device used for alleviating the pulmonary arterial hypertension of congenital heart disease, and particularly relates to the technical field of medical apparatus and instruments. The occlusion device used for alleviating the pulmonary arterial hypertension comprises an occlusion part and a shunting part, wherein the shunting part is embedded in the axial centerposition of the occlusion part and penetrates through the occlusion part; the main body of the occlusion part is of a reticulate structure, and the periphery of the occlusion part is coated with a layer of high molecular elastic film; and a one-way valve capable of achieving one-way conduction is installed in the axial direction of the shunting part. After the occlusion device is installed, a one-way channel which prevents left-to-right shunting and only permits right-to-left shunting is formed so as to facilitating eliminating of the volume overload of pulmonary vessels and pressure conduction, further injury of pulmonary vessels is lightened, and meanwhile, right-to-left shunting is kept to prevent a serious consequence since pulmonary arterial pressure suddenly rises. The occlusion device is favorable for alleviating the pulmonary arterial hypertension of the congenital heart disease and is suitable to be prompted and used in medical organizations.

The invention discloses a method for constructing a congenital heart disease with diminutive pulmonary blood animal model, which is characterized in that: a surgical knife enters a fourth intercostal of right chest lateral incision, and a pericardium is opened and suspended; an interatrial septum is directly expanded by a puncture needle and a balloon dilator from the right chest lateral under ultrasound guidance to form an atrial septal defect with the diameter of 1.0cm; a main pulmonary artery is sleeved by an artificial blood vessel sheet to monitor peripheral arterial blood pressure and differential pressure of a girdle place, and then the differential pressure is decreased gradually; and when the differential pressure of the girdle place of mild-moderate pulmonary stenosis is 20 to 30mmHg, or the differential pressure of the girdle place of severe pulmonary stenosis is more than or equal to 30mmHg, and the arterial blood pressure is kept stable, a girdle belt is fixed so as to form the congenital heart disease with diminutive pulmonary blood animal model. The method has the advantages of exactness, feasibility, simple and reliable operation method, convenient operation and a few complications; and the constructed animal model is more ideal and better adapts to changes of clinical pathophysiology of the disease.

The invention discloses a novel snare for interventional therapy of congenital heart diseases. The novel snare comprises a snare ring, a nickel-titanium rod, a handle and a macromolecule heat shrinkable tube; the snare ring comprises a tail end extending along a direction vertical to a plane on which the snare ring is arranged; the tail end of the snare ring is fixedly connected with the bottom end of the nickel-titanium rod, and the nickel-titanium rod is vertical to the plane on which the snare ring is arranged; the snare ring is made of a nickel-titanium rope; the handle is fixed at the top end of the nickel-titanium rod; and the macromolecule heat shrinkable tube is compactly sleeved at the bottom of the nickel-titanium rod and the tail end of the snare ring. In the invention, the snare ring is made of the nickel-titanium rope formed by weaving a plurality of strands of nickel-titanium alloy wires, so that the snare ring has higher reliability compared with a snare ring made of a single strand of nickel-titanium alloy wire; meanwhile, the tip of the snare ring is softer so that unnecessary damage to the body of a human, particular to children, is not easy to produce.

The present invention pertains to a nucleic acid sequence encoding a human TFIIH 8 kDa subunit and related sequences. The nucleic acids may be used in methods for producing a TFIIH subunit, as well as in methods for diagnosing or treating transcription and NER deficiencies, in particular in some forms of trichothiodystrophy (TTD). The hTFB5 / TTDA gene and encoded protein may be used for therapy or genetherapy products, aimed at treating congenital NER disorders and may also be used in methods of diagnosis of disorders in basal transcription, NER and TCR activity in mammals, using molecular probes or antibodies specific for TTDA.

The invention discloses a winter chick incubating method. The chick incubating method is put forward in order to solve the problems that winter chick incubating is difficult and the chick death is high. The survival rate of chicks is greatly increased. By means of the strict control over the disinfection work of an incubating room, the control over humidity and temperature and the indoor reasonable and effective ventilation and circulation, the stress stimulation of harmful gases to chick flocks is reduced, the morbidity is reduced, and feeding is fine and delicate; by adding brown sugar waterto drinking water, congenital diseases of the chicks are removed, and energy is compensated for; by means of a matched saline solution, organism dehydration of the chicks caused by enterogastritis isavoided; by means of a matched clopidol solution, globidiosis can be avoided; the environment is properly adjusted according to the growth of the chicks, and the chicks are prevented from invasion ofviruses and bacteria; the problems that the chicks incubated in winter are not high in survival rate, easily suffer from diseases and are not healthy in physique and poor in uniformity are solved, required nutrients are given, the feeding management is proper, and the physique and disease resistance of the chicks are improved.

The invention discloses a visual amplatzer conveying and positioning apparatus for interventional therapy of congenital heart disease, comprising an outer sheath; one end of the outer sheath is in threaded connection to a first screw cap, an inner sheath is arranged in the outer sheath, one end of the inner sheath is in threaded connection to a second screw cap, one side of the outer sheath far away from the first screw cap is provided with a monitor, a telescopic rod is arranged between the monitor and the outer sheath, the monitor is connected with the outer sheath through the telescopic rod, the bottom end of the telescopic rod is provided with a rotating device, the rotating device comprises a rotating portion and a fixed portion, the rotating portion of the rotating device is connected to the telescopic rod, and the fixed portion of the rotating device is fixedly connected to the sidewall of the outer sheath. Outer sheath positioning is accurate, surgical risk is reduced, vascular injury is avoided, X-ray imaging is not required for the surgical process, no irradiation damage is caused to doctors and patients, and working efficiency is improved. The visual amplatzer conveying and positioning apparatus for interventional therapy of congenital heart disease is applicable as an opening combination for congenital heart disease.

The invention discloses an intelligent surgical conveying device for the interventional therapy of the congenital heart disease. The intelligent surgical conveying device comprises an outer sheath tube, a loading sheath, a handle, a push block, a push rod, a sensor, a connecting wire and a control system. The handle is connected to the tail end of the outer sheath tube. The push block, the push rod and the sensor which are sequentially connected are arranged in the handle. The other end of the sensor is connected with the control system through a connecting wire. The loading sheath can be inserted into the outer sheath tube. The tail end of the loading sheath makes contact with the front end of the push block. A closure device can be conveyed through ultrasonic guidance, no radial trauma is caused to personnel in the surgery process, developing is not needed, and no medicine damage is caused; the closure device can be intelligently conveyed through the sensor and the control system.

The invention discloses an external traditional Chinese medicine for treating oviduct obstruction and a preparation method of the external traditional Chinese medicine. The external traditional Chinese medicine can treat oviduct obstruction infertility, has good effects, has efficacy of removing blood stasis, promoting blood circulation to remove blood stasis, dredging collaterals, inducing diuresis and the like and has very significant effects of improving microcirculation, promoting macrophage cell proliferation, promoting local adhesion and connective looseness, promoting inflammation lumpabsorption, promoting lesion elimination and the like. The medicine is an external medicine, discomfort caused by existing drinking liquid medicines to the human body is avoided, and the medicine candirectly permeate to focuses. The medicine is safe in clinical application and short in curative effect, and relapse cannot occur easily; the medicine has wide use ranges and can effectively treat inflammation, hydrops, adhesion, obstruction, tuberculosis, congenital diseases, ovarian cyst, benign tumor and other symptoms as well as infertility caused by various oviduct obstruction causes.

The invention relates to a teraHertz wave physiotherapy device for congenital deafness diseases of children. The device comprises a processing end, a wave emission terminal connected with the processing end and a head hoop assembly provided with the wave emission terminal, wherein the processing end is used for signal transmission, teraHertz wave frequency signal processing, control and control over the whole system and data processing; the wave emission terminal is internally provided with teraHertz wave generators, and the front sides of the teraHertz wave generators are provided with horn mouths for guide wave transmission; the head hoop assembly comprises a hoop rod and two fixing parts, close to the end of the hoop rod, arranged on the hoop rod, the ends of the fixing parts are connected with annular positioning rings, the positioning rings are overlapped and fixed with the shapes of extension parts, and when the positioning rings and the extension parts are overlapped, the frontends of the horn mouths penetrate through the positioning rings and stretch out of the positioning rings; the inner sides of the fixing parts extend inwards to be provided with positioning rods, and the ends of the positioning rods are connected with suspension loops matched with the outer contours of the upper portions of the ears. The device has the advantages that the design is novel, wearing is convenient and fast, and the operation steps of medical workers are reduced.

The invention discloses a method for searching an ALK3 downstream gene related to congenital heart disease-ventricular spetal defect. The method comprises the following steps: adopting rat embryo (11.5 days) of Alpha-MHC-Cre+ / -, ALK3F / -(testing group) and Alpha-MHC-Cre+ / -, ALK3F / +(contrasting group), and using a PCR selective cDNA difference display method and a gene chip method to carry out initial screening, thus obtaining possible ALK3 downstream candidate genes; subsequently adopting an RT-PCR method with lower cost to eliminate false positive ALK3 downstream candidate genes; subsequently using an in-situ hybrid method to carry out expression part validation on the ALK3 downstream candidate genes remained after the elimination by the RT-PCR method; and approving the ALK3 downstream gene related to be the congenital heart disease-ventricular septal defect. The method provides a theoretical base for developing the curative gene medicine of ventricular septal defect and finds new curative targets for exploring new medicine.

The invention provides a method and device for screening the congenital heart disease, equipment and a storage medium. An information circulation method for a child patient suffering from the congenital heart disease comprises the following steps of S1, information input; S2, generation of a bar code; S3, input of data detected by using a double-index method; S4, data comparison, wherein if the child patient suffers from the congenital heart disease, the step S5 is executed; if the child patient does not suffer from the congenital heart disease, negative is output; S5, input of echocardiography detection data; S6, receiving of diagnostic information; S7, output of the diagnostic information. By means of the method, a detection report can be remotely transmitted to a provincial hospital soas to allow a doctor in the provincial hospital to view the report and make a diagnosis result, and the time for diagnosing the child patient is greatly shortened. Each child patient has the corresponding bar code, a medical worker can scan the bar codes to view detection report information of the child patients, data transmission is precise, information confusion is prevented in the transmissionprocess, a great reference value is provided for the practical diagnosis of the doctor, and misdiagnosis is avoided.

The invention provides an ibuprofen pharmaceutical composition, wherein ibuprofen concentration is 4.5-5.5mg / ml and tromethamine concentration is 3.6-4.0mg / ml. The invention also provides a preparation method of the ibuprofen pharmaceutical composition, wherein the preparation method comprises the following steps: (1) adding tromethamine, sodium hydroxide and sodium chloride to injection water, stirring until the materials are dissolved and adding ibuprofen; (2) heating and cooling the mixed materials in a circulating mode at least twice, wherein the heating-cooling circulation means to heat the materials from 10-30 DEG C to 40-60 DEG C and then to cool the materials from 40-60 DEG C to 10-30 DEG C; and (3) filtering, filling and sterilizing so as to obtain the ibuprofen pharmaceutical composition. Through the technical scheme, the stability of the ibuprofen pharmaceutical composition is significantly improved.

The invention relates to a method for preparing a teaching specimen of an apical four-chamber view of a stillbirth suffered from a congenital heart disease. The method comprises the following steps: selecting an artificial labored fetus having a malformed heart; antiseptically treating the artificial labored fetus to prepare a free heart specimen, and making the vertical axis of the view parallel to the long axis of the heart and making the horizontal axis of the view parallel to the left-right direction of the heart from the apex of the heart,; and along the direction from the front upper position of 1 to 2 centimeters of left and right edges of the heart to the base of the heart, cutting the heart from the center of the right atrium and a position nearby an orifice of a pulmonary vein of the left atrium. The obtained apical four-chamber view specimen has the advantages of integrated and complete structures of all parts, no damage to microstructures in the heart, the same shape as that in a real living body, and capability of meeting the requirements of medical teaching and practice and the like, and is suitable for schools, hospitals or medical research institutes.

An oxygen inhalation device for relieving tachypnea of an infant suffering from a congenital heart disease belongs to the technical field of medical devices. When treated, the infant suffering from the congenital heart disease possibly has tachypnea syndrome due to pain caused by the fear and the illness state of the infant, a medical worker often slightly covers an oral area of the infant with a hand to adjust the amount of inhaled carbon dioxide gas in order to eliminate the syndrome, the infant is possibly more frightened by the operation process, and even the life of the infant is threatened. The technical scheme of the oxygen inhalation device includes that an oxygen inlet plug tube (9) with a switch (10) is communicated with a flare tube (1) in a fixedly connected manner, a low end opening of the flare tube (1) is communicated with a silicon rubber gasket (6) in a fixedly connected manner, an upper end opening of the flare tube (1) is communicated with a thin straight tube (2) in a fixedly connected manner, and a small-diameter end opening (4) is arranged at an upper end opening of the thin straight tube (2). The oxygen inhalation device has the advantages that the device has complete design functions, the infant suffering from the congenital heart disease can be treated in a composite manner, and medical rescue efficiency is greatly improved.

The invention provides a blood flow limiter for a congenital heart disease interventional operation. The blood flow limiter comprises a flow limiting structural body and a flow limiting rotating piece. The flow limiting structural body comprises a flow limiting fixed piece and a tubular support frame. A through hole is formed in the flow limiting fixed piece. The flow limiting fixed piece is fixedly connected to one end of the tubular support frame. The size of the flow limiting fixed piece is not smaller than the size of the end face, to which the flow limiting fixed piece is connected, of the tubular support frame. The flow limiting rotating piece is rotatably connected to an end face of the flow limiting fixed piece in such a manner of rotating in one way. The flow limiting rotating piece is rotated to adjust the size of a blood flow passage formed by the flow limiting rotating piece in match with the through hole in the flow limiting fixed piece, thus realizing adjustment of blood flow. The area of the blood through hole can be adjusted from 0 to the maximum area of the through hole in the flow limiting fixed piece, so that the blood flow of pulmonary artery can be adjusted according to actual situations after the operation; and therefore, the optimal treatment effect can be achieved.

The invention relates to a device for relieving tachypnea of children with a congenital heart disease, belonging to the technical field of medical devices. When some children with the congenital heart disease see a doctor treating the case, the children probably generate tachypnea syndrome due to fear and pain caused by illness; in order to eliminate the symptom, medical workers always gently cover the mouth to regulate the quantity of inspired carbon dioxide gas; and the operation process probably causes the children with the congenital heart disease to be more scared or threatens the life. The technical scheme of the device is that: the lower port of a horn tube (1) is fixedly connected and communicated with a silicone rubber washer (6), and the upper port of the horn tube (1) is fixedly connected and communicated with a fine straight tube (2); the upper port of the fine straight tube (2) is provided with a small-diameter port (4); and the lower port of the silicone rubber washer (6) is provided with a large-diameter port (5). The device has the advantages that the tachypnea symptom of children can be effectively eliminated, and the device is beneficial to the children with the congenital heart disease; the device is simply and conveniently operated, and the time and labor are saved; and the treatment efficiency is greatly increased.

The invention relates to an oxygen inhalation device relieving shortness of breath of a child with congenital heart disease, which belongs to the technical field of medical equipment. A child with congenital heart disease, who seeks for medical help in a hospital, may have tachypnea syndrome due to discomfort caused by fear and illness, in order to eliminate the symptom, medical workers always use hands to gently cover the mouth of the child, in which the child may be further fear. The technical scheme of the invention is as follows: an oxygen inlet plug pipe (9) with a switch (8) is fixedly connected and communicated with a flared pipe (1), the flared pipe (1) is fixedly connected and communicated with a fine straight pipe (2), a small-diameter port (4) is arranged on the upper port of the fine straight pipe (2), a large-diameter port (5) is arranged on the lower port of the flared pipe (1), a front rubber belt lantern ring (6) and a rear rubber belt lantern ring are both fixedly connected with the large-diameter port (5), and an air door switch (3) is installed on the fine straight pipe (2). The oxygen inhalation device of the invention is easy and convenient to operate, and is time-saving and labor-saving, and greatly improves medical treatment efficiency.

The invention discloses a congenital aniridia disease-causing gene, a kit for detecting the congenital aniridia disease-causing gene and an application of the gene. The congenital aniridia disease-causing gene is a mutational PAX6 (Paired box6) gene, one point of a basic group in a 323th site of a sixth exon of the PAX6 gene is muted to A from C, and a genetic codon (TCC) for encoding serine at a 108th site is changed into a genetic codon (TAC) for encoding tyrosine, namely S108Y mutation is caused. The invention also provides a kit used for detecting the congenital aniridia disease-causing gene. The kit used for detecting the congenital aniridia disease-causing gene comprises 2mM dNTPs, 10*PCR (Polymerase Chain Reaction) buffer solution, DNA polymerase, PCR amplification primer pairs and double distilled water, wherein the PCR amplification primer pair is composed of a primer 1 (shown in SEQ ID NO:1) and a primer 2 (shown in SEQ ID NO:2). The invention provides a new congenital aniridia disease-causing gene, so that a new technological means is provided for genetic diagnosis of congenital aniridia, and a foundation is also laid for study of a pathogenetic molecular mechanism.

The invention relates to an apparatus and method for identifying blood vessels in an angiography-assisted congenital heart disease operation. The apparatus comprises a CT image preprocessing module, a segmentation module, a three-dimensional reconstruction module, a two-dimensional planarization module, a contrast imaging module, a registration initialization module, a quantum updating module, an individual mutation module, a mutation post-processing module, an image registration module and a blood vessel identification result display module, wherein the CT image preprocessing module, the segmentation module, the three-dimensional reconstruction module and the two-dimensional planarization module are used before the operation, and the contrast imaging module, the registration initialization module, the quantum updating module, the individual mutation module, the mutation post-processing module, the image registration module and the blood vessel identification result display module are used in the operation. The method includes the following steps that: a preoperative image is segmented; three-dimensional visual reconstruction is performed on segmented CT images, so that segmented two-dimensional images of a preoperative heart and preoperative blood vessels are obtained; and the segmented two-dimensional images of the preoperative heart and preoperative blood vessels are registered with intra-operative contrast images, and results obtained after registration are displayed. With the apparatus and method of the invention adopted, the registration results have high precision and rich detail information, and therefore, the accurate positions of the blood vessels of a patient can be provided for a doctor in a congenital heart disease operation, and the difficulty of the operation can be reduced.

The invention discloses a congenital heart defect (CHD)-related gene family with sequence similarity 71, member A (FAM71A) and an application thereof and in particular provides a method for detecting CHD susceptibility. The method comprises the step of detecting whether the gene FAM71A, transcript and / or protein of an individual undergo variations compared with the normal gene FAM71A, transcript and / or protein, wherein the individual is more likely to suffer from CHD than normal people if variations exist. The invention also discloses a corresponding detection kit, especially a prenatal diagnosis kit.

The invention relates to a method for preparing a teaching specimen of a left ventricular outflow tract view of a stillbirth suffered from a congenital heart disease. In the method, a free heart specimen is prepared after a selected artificially-labored fetus having a malformed heart is antiseptically treated; and in the left ventricular outflow tract view, the horizontal axis of the view is parallel to the long axis of the heart by taking a pulmonary conus as a start point of a cross section, the cross section is up to a superior vena cava through aorta ascendens and down to the apex of the heart through an anterior interventricular groove. The obtained apical four-chamber view specimen has the advantages of integrated and complete structures of all parts, no damage to microstructures in the heart, the same shape as that in a real living body, and capability of meeting the requirements of medical teaching and practice and the like, and is suitable for schools, hospitals or medical research institutes.

The invention relates to the technical field of traditional Chinese medicine and health-care products, in particular to pills capable of strengthening muscles and bones and increasing height and a preparing method and application thereof. The pills capable of strengthening muscles and bones and increasing height are prepared from prepared rhizome of rehmannia, fructus lycii, myrrh, cortex acanthopanacis, frankincense, radix morindae officinalis, cortex lycii radicis, radix dipsaci, cortex eucommiae, rhizoma drynariae, cornua cervi pantotrichum, radix achyranthis bidentatae, flowers carthami, white poria and native copper. According to the pills capable of strengthening muscles and bones and increasing height, main medicine and subsidiary medicine are combined, and child retardation of walking, dysplasia, weakness and inability, and limitation to muscle and bone stretching and other congenital diseases caused by bad factors, undernutrition or acquired susceptibility to diseases can be effectively treated.

An appliance for relieving tachypnea of an infant suffering from a congenital heart disease belongs to the technical field of medical devices. When treated in a hospital, the infant suffering from the congenital heart disease possibly has tachypnea syndrome due to pain caused by the fear and the illness state of the infant, a medical worker often slightly covers an oral area of the infant with a hand in order to eliminate the syndrome, but the infant suffering from the congenital heart disease is possibly more frightened by the operation process. The technical scheme of the appliance includes that a lower end opening of a flare tube (1) is communicated with a silicon rubber gasket (6) in a fixedly connected manner, an upper end opening of the flare tube (1) is communicated with a thin straight tube (2) in a fixedly connected manner, a small-diameter end opening (4) is arranged at an upper end opening of the thin straight tube (2), a large-diameter end opening (5) is arranged at a lower end opening of the silicon rubber gasket (6), and two ends of a front rubber tape sleeve ring (7) and two ends of a rear rubber tape sleeve ring (8) are fixedly connected with the large-diameter end opening (5). The appliance has the advantages that the appliance is simple and convenient in operation, time and labor are saved, and medical efficiency is greatly improved.

A PNA zip-code chip in which PNA zip-code probes are immobilized on a substrate at high density using an epoxy compound as a linker, and method for fabricating such PNA chip. The use of PNA provides the chip with superior properties to DNA chips, allowing precise diagnosis of congenital diseases or base mutations with much higher sensitivity than is achievable with a DNA chip. The use of the PNA zip-code chip enables diagnosis of gene mutations in a simple manner, using only hybridization reaction, without the difficulties associated with processes in which probes must be immobilized directly on a substrate every time the target gene changes.