The invention discloses a slip boundary condition density flow and saline wedge generation experiment device. The slip boundary condition density flow and saline wedge generation experiment device comprises an experimental water tank, a conveying floor, a fixing floor, a water guide tank, a low-density water storage tank, a high-density water storage tank, a removable rectifying device, a diversion device, a water inlet tank, an external drainage pipe, a level baffle, a water outlet, a scale, a cross calibration line, a control valve, a flowmeter, a filter, a small water pump and a mixer. Theslip boundary condition density flow and saline wedge generation experiment device can be applied to slip boundary condition density condition experiment, saline wedge generation experiment and traditional continuous inflow density flow experiment, can eliminate lobe-and-cleft phenomena in the head area during density flow diffusion to simplify three-dimensional motion into two-dimensional motionand facilitate phenomenon mechanism analysis, and meanwhile, lay an experimental foundation for complicated three-dimensional analysis and allow conversion to saline wedge conditions through simple operation. Besides, the slip boundary condition density flow and saline wedge generation experiment device is flexible in component combination design and wide in applicable condition range.