The invention discloses a method for extracting collagen from squid skin. The method comprises the following steps: adding a NaOH aqueous solution in squid skin, ultrasonically soaking, then soaking and degreasing by using an isopropanol solution, cleaning, and draining; adding an acetic acid solution into the preprocessed squid skin, stirring, extracting, centrifuging, precipitating, washing by using water until the solution is neutral, drying for standby use, salting out the supernatant, dissolving by using acetic acid, dialyzing, freeze drying, and obtaining acid-soluble collagen; adding neutral protease and distilled water in acid extracted precipitates, enzymolysing, centrifuging, salting out the supernatant, dissolving by using the acetic acid, dialyzing, freeze drying, and obtainingthe enzyme-soluble collagen. The method has the beneficial effects that the extraction is simple, the industrialized production is easy to realize, the safety is higher, the extraction rate of the collagen is high, the additional value of the squid skin is greatly increased, and the market development potential is great; and the collagen obtained by the extraction method is white in color, free from fishy taste and high in product purity.