The invention belongs to the technical field of polytetrafluoroethylene pipe flanging, and particularly relates to a polytetrafluoroethylene pipe flanging hot-pressing device. The device comprises a base, a telescopic machine is arranged at the upper end of the base, a telescopic rod is connected to one end of the telescopic machine, a hot-pressing die is connected to one end of the telescopic rod, a limiting annular plate is arranged on one side of the hot-pressing die, a positioning column is arranged at the axis of the limiting annular plate, the back of the base is provided with a connecting bracket, a top plate is connected to one end of the connecting bracket, a connecting rod penetrating to the bottom end is arranged at the top of the top plate, a hydraulic telescopic machine is arranged at one end of the connecting rod, an upper fixing plate is arranged at the lower end of the top plate, and a lower fixing plate is arranged at the lower end of the upper fixing plate. By arranging the fixing plates, pipelines can be well fixed, operation becomes simple, and the pipelines with different lengths can be subjected to flanging treatment; and meanwhile, positioning column is arranged, the positioning column can be replaced according to the pipelines with different diameters, and therefore the equipment is multipurpose, and the flanging treatment effect is good.