The invention discloses a multi-wavelength ozone laser radar based on a single-photon CCD, comprising: a Nd-YAG quadruple frequency laser, an optical lens, a Raman tube, a beam expander, a plane mirror, an optical receiving module, a spectrometer, a detection module, Data acquisition and synchronization control unit. The present invention is based on a single Raman tube stimulated Raman to generate multi-wavelength lasers. By using the echo signals of different wavelength pairs for differential inversion, the ozone concentration can be measured with high precision within a large vertical height range. The use of the Mann tube not only simplifies the device, but also reduces the difference in geometrical factors of different wavelength lasers and improves the measurement accuracy of the device. In addition, the use of single-photon CCD not only simplifies the composition of the detection part, reduces the measurement error caused by the difference of the detector, makes the lidar device have a large upgrade space, but also benefits from the high sensitivity of single-photon detection , increasing the maximum measurement height of the device.