The invention relates to a centroid-driven focusing mechanism based on a flexible hinge. The centroid-driven focusing mechanism comprises a base, two sets of guide rail sliding blocks, a lens group bracket, an optical lens group, the flexible hinge, a driving connecting rod, a linear motor and a linear motor bracket. Through the two sets of guide rail sliding blocks, a high-precision linear motionsupport is provided for the optical lens group and the lens group bracket, and the linear motor is utilized as motion drive of the optical lens group and the lens group bracket; on the basis of the flexible hinge, the requirement for the angular deviation error between the driving axis of the linear motor and the motion direction of the optical lens group is reduced; and through the driving connecting rod, it is ensured that a driving force-bearing point of the lens group bracket is located between the two sets of guide rail sliding blocks, and thus a centroid-drive form is achieved. According to the focusing mechanism, through the flexible hinge and the driving connecting rod, the influences of the assembly angular deviation error of the linear motor and driving force eccentricity on themotion precision of the lens group are effectively relieved, the problems of jamming, hysteresis and the like of the lens group are avoided, and meanwhile, the assembly complexity of the focusing mechanism is reduced.