The invention discloses a technical method for large-scale production of particles by a multi-nozzle module based on a 3D (three-dimensional) printing technique and application of the technical method. The technical method is characterized in that a single nozzle is of a coaxial annular gap air blowing structure, the middle part is provided with a fluid channel, and the coaxial annular gap is an air channel; on the basis of a two-phase flow cutting principle, liquid-phase liquid is cut by air, and liquid droplet particles are produced; by controlling air and liquid outlet pressures and flow rates, the liquid droplets with different particle sizes can be obtained; the number of nozzles can be designed according to the requirement of droplet output, and liquid and air are uniformly distributed by a distributor, so as to obtain higher droplet production efficiency. The technical method has the advantages that the preparation of 3D printing nozzle modules is simple, the material cost is low, and other complicated mechanical processing methods are not required; the prepared particles are free from the pollution by poisonous matters, such as a continuous phase and surfactants; the technical method is especially suitable for preparing high-viscosity solution and suspension droplets containing insoluble particles, is widely applied to the fields of medical care, petroleum, biology, environment protection and the like, and is suitable for large-scale industrial production.