The invention discloses an ion exchange resin filling method for a space product. The ion exchange resin filling method comprises the following steps: 1, implementing preparation before production; 2,cleaning ion exchange resin; 3, cleaning and drying an ion exchanger; 4, putting the ion exchange resin into the ion exchanger, and placing the ion exchange on a power frequency vibration platform soas to obtain an ion exchanger filled with the ion exchange resin in a vibration manner; 5, performing sealed packaging on the ion exchanger; 6, performing vacuum exhausting on the ion exchange so asto obtain a filled ion exchange; 7, testing the filled ion exchange, thereby obtaining a qualified ion exchange. By adopting a filling method of vibration filling+vacuum injection exhausting, the amount of filled ion exchange resin is numeralized, the filling density of the ion exchange resin is maximized, the air among resin granules is effectively discharged, the influence of the air to the exchange efficiency of the ion exchange resin is reduced, and the service life of the whole ion exchange is prolonged.