The invention relates to a mariculture wastewater treatment system and treatment method. The mariculture wastewater treatment system comprises a slanting board sedimentation pool and a three-section nitrogen and phosphorus removal pool which communicate with each other, wherein the three-zone nitrogen and phosphorus removal pool comprises a water distribution area, an anoxic zone, an aerobic zone, a phosphorous removal zone and a water collection area which are arranged in sequence, the anoxic zone is filled with gravel substrates, the aerobic zone is filled with zeolite substrates and equipped with a perforated aerator pipe, the phosphorous removal zone is filled with phosphorous removal functional filler substrates, a water inlet pipeline is arranged at the bottom end of the slanting board sedimentation pool, the top end of the slanting board sedimentation pool communicates with the water distribution area, the water collection area is equipped with a water outlet pipeline, and a return pipeline is arranged between the water collection area and the water distribution area, so that part of treated water is conveyed back to the water distribution area through the return pipeline. Compared with the prior art, the turbidity and the content of soluble COD, nitrogen and phosphorus in water can be reduced simultaneously, an A/O biological contact oxidation technology and an adsorption phosphorous removal technology are combined creatively to be applied to the field of seawater treatment, and the problem about large-scale purified emission of mariculture wastewater is solved.