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33 results about "2-Acetylpyridine" patented technology
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2-Acetylpyridine is an organic compound with the formula CH₃COC₅H₄N. It is a viscous colorless liquid that is widely used as a flavoring substance. It is found in malt and produced by the Maillard reaction and by nixtamalization. It contributes to the flavor of corn tortillas, popcorn, and beer.
Method for synthesizing doxylamine succinate
The invention discloses a method for synthesizing doxylamine succinate. 2-acetylpyridine is taken as an initiative material, and the method comprises the following steps of: reacting the 2-acetylpyridine with a Grignard reagent prepared from bromobenzene and magnesium to obtain 2-pyridyl phenyl methyl carbinol; reacting the 2-pyridyl phenyl methyl carbinol with sodium amide and 2-dimethylaminoethyl chloride in turn to obtain doxylamine; and performing salt-forming reaction on the doxylamine and succinic acid to obtain the doxylamine succinate. The synthesis route is orientation reaction without byproduct. The doxylamine succinate is an ethanol antihistamine, and has antihistaminic and cholinolytic effects and obvious tranquillizing effect.
Owner:HEFEI UNIV OF TECH +1
Salted egg yolk essence
ActiveCN108618097AFragrance aroma is pure and fullIncrease the fragranceFood scienceFood additiveFurfural
The invention discloses salted egg yolk essence which is composed of caprylic capric glyceride, dimethyl sulfide, 3-hydroxy-2-butanone, dimethyl disulfide, 1-octylene-3-alcohol, furfural, 5-methyl furfural, 3-methylthiopropanal, 2-acetylpyridine, 3-methyl methylthiopropionate, 2-acetylthiazole, methyl(2-methyl-3-furyl)disulfide, isovaleric acid, 2, 4-decadiene aldehyde, ethyl maltol, 3-methylthiopropanol, caprylic acid, 2, 4-dimethyl-5-acetylthiazole, heliotropin, vanillin, capric acid, 2-pentylfuran, isovaleraldehyde, furanone and 2-acetylpyrazine. The salted egg yolk essence is authentic andfull in fragrance, low in cost, good in fragrance lasting and penetrating in fragrance, has the advantage of being delicious, fragrant and oily and can serve as a food additive to be applied in producing food like bake and beverages.
Owner:GUANGZHOU HUABAO FOOD CO LTD
Fluorescent probe capable of identifying iodide ions as well as preparation method and identification method thereof
The invention discloses a fluorescent probe capable of identifying iodide ions and a preparation method and an identification method thereof. The preparation method comprises the following steps of (1) dissolving 4-bromobenzaldehyde into ethyl alcohol, so as to obtain a product A; (2) dissolving 2-acetylpyridine, potassium hydroxide and ammonium hydroxide into ethyl alcohol, so as to obtain a product B; (3) enabling the product A and the product B to react, filtering precipitate, and re-crystallizing, so as to obtain a product C; (4) adding the product C, 4-pyridine vinyl, palladium acetate and triphenylphosphine into triethylamine to mix, dissolving the product into chloroform, spin-drying, and re-crystallizing, so as to obtain a product D; (5) suspending 1,8-naphthalimide into a mixtureof N,N-dimethylformamide and DMSO (dimethylsulfoxide), adding sodium methoxide, stirring, standing, adding 1,4-dibromobutane, filtering precipitate, and re-crystallizing, so as to obtain a product E;(6) adding the product D into N,N-dimethylformamide, adding into the product E, adding diethyl ether until the precipitate is separated out, sucking and filtering, and drying, so as to obtain the fluorescent probe. The fluorescent probe has the characteristics that the identification cost is low, the operation is simple and quick, the sensitivity is high, and the selectivity is good.
Owner:GUIZHOU UNIV
Fluorescent probe for identifying mercury ions and preparation and identification method thereof
ActiveCN109928912AReduce testing costsEasy to operateOrganic chemistryFluorescence/phosphorescenceN dimethylformamideFluorescence
The invention discloses a fluorescent probe for identifying mercury ions and a preparation method and an identification method thereof. The preparation method comprises the following steps: firstly dissolving 4-bromobenzaldehyde in ethanol so as to obtain a; dissolving 2-acetylpyridine, potassium hydroxide and ammonia water in ethanol to obtain b; mixing the a and the b, carrying out reacting to obtain a precipitate, filtering the precipitate, and recrystallizing the precipitate in acetic acid to obtain c; mixing the c , 4-pyridine ethylene, palladium acetate and triphenylphosphine into triethylamine to obtain a mixture, and sealing the mixture in a high-pressure reaction flask under N2 atmosphere for reaction, dissolving a product in chloroform, performing spin-drying, and recrystallizingwith ethanol to obtain d; and dissolving the d into N, N-dimethylformamide, then adding 6-bromohexanoic acid to react, adding diethyl ether into the reaction solution until the reaction solution is completely precipitated, carrying out suction filtration, washing twice with diethyl ether, and drying to obtain the fluorescent probe for identifying the mercury ions. The fluorescent probe can realize qualitative and quantitative analysis of the mercury ions, and has the characteristics of low identification cost, simplicity in operation, visual result, high sensitivity, good selectivity and thelike.
Owner:GUIZHOU UNIV
Organic white light material o-pyridine p-benzene bis(imino) cadmium/mercury complex and preparation method thereof
ActiveCN103265945AImprove stabilitySimple methodEnergy efficient lightingLuminescent compositionsBenzeneFluorescence
The invention provides an organic white light material o-pyridine p-benzene bis(imino) cadmium / mercury complex and a preparation method thereof, relates to an organic light-emitting material and a preparation method therefore, and aims at solving the problems of the conventional white light-emitting material that the synthesis process is complex, the yield is low and the service life of fluorescence is short. The organic white light material consists of an o-pyridine p-benzene bis(imino) cadmium complex [N, N'-bis(2-acetylpyridine methylene) benzene-1, 4-diamine] CdCl2 and an o-pyridine p-benzene bis(imino) mercury complex [N, N'-bis(2-acetylpyridine methylene) benzene-1, 4-diamine] HgCl2. The preparation method comprises the following steps of: 1, dissolving N, N'-bis(2-acetylpyridine methylene) benzene-1, 4-diamine and CdCl2 or HgCl2 into methanol, and heating and refluxing; 2, filtering turbid reaction liquid and collecting solid powder; and 3, washing with methanol to obtain the organic white light material. The preparation method is simple in synthetic process, the yield can be up to more than 60%, and the service life of fluorescence is relatively long.
Owner:湖南哈工机器人研究院有限公司
Probe and preparation method and application thereof
ActiveCN106966962AEasy to operateTest results are visibleOrganic chemistryFluorescence/phosphorescenceAlkaneReflux
The invention discloses a probe and a preparation method and application thereof. The preparation method includes mixing and stirring 4-bromobenzaldehyde, 2-acetylpyridine, 4-vinyl pyridine, brominated alkanes, ammonium hydroxide, palladium acetate, triphenyl phasphine, triethylamine and DMF (dimethylformamide) prior to reflux, stirring for 1 hour at a room temperature to obtain a precipitate, filtering and recrystallizing in acetic acid so as to obtain a reactant; taking the reactant out, cooling the reactant to the room temperature to generate a precipitate, filtering to obtain a solid and drying the solid so as to obtain the probe. The probe is capable of quantitatively analyzing Zn<2+> concentration in a solution and has the advantages of low quantitative analysis concentration, high anti-interference capability, simplicity in operation, visual results and simplicity and convenience in analysis.
Owner:GUIZHOU UNIV
Peanut essence and preparation method thereof
InactiveCN106262579AImprove coordinationLong lasting fragranceFatty-oils/fats productionFood scienceButylated hydroxyanisoleFood additive
The invention relates to the technical field of food additives and in particular discloses peanut essence and a preparation method thereof. The peanut essence is prepared from the following raw materials in parts by weight: 20 to 50 parts of peanut oil, 0.5 to 3 parts of maltol, 0.1 to 1 part of 2-acetylpyridine, 0.05 to 0.3 part of acetylpyrazine, 0.05 to 0.5 part of sulfurol, 0.2 to 1 part of 2,3,5-trimethylpyrazine, 0.01 to 0.05 part of 2,4-decadienal, 0.2 to 1 part of vanillin, 30 to 50 parts of salad oil and 0.2 part of an antioxidant BHA (Butylated Hydroxyanisole). The essence provided by the invention has good aroma coordination, can keep the aroma for a long time and can resist high temperature better.
Owner:广州馨杰添加剂有限公司
L-phenylalanine schiff-base metal copper complex monocrystalline and preparation method thereof
InactiveCN107043390AClear structureGood crystal formGroup 1/11 organic compounds without C-metal linkagesOrganic chemistry methodsAmino acid synthesisSpace group
The invention discloses L-phenylalanine schiff-base metal copper complex monocrystalline and a preparation method thereof. A molecular formula of the complex monocrystalline is C32H30 Cl2Cu2N4O4, a space group is P21 / c, the cell parameter alpha is 12.4595(8) angstrom, b is 8.8566(6) angstrom, c is 14.5085(9) angstrom, alpha is 90 DEG, beta is 101.982(2) DEG C, gamma is 90 DEG, the crystal cell volume V is 1566.11(18) A<3>, and F(000) is 748. The method comprises the following steps: L-phenylalanine and 2-acetylpyridine are subjected to 2-acetylpyridine L-phenylalanine schiff-base ligand, and the ligand and bivalent copper salt are used for preparing the L-phenylalanine schiff-base metal copper complex monocrystalline by a one-step solvothermal method. According to the invention, the solvothermal method is employed for reactive synthesis of the ligand and the divalent metal copper ion copper ions to obtain the L-phenylalanine schiff-base metal copper complex under condition that high temperature for schiff base decomposition and high pressure due to boiling of methanol are not generated, the blue monocrystalline with good crystal form is obtained; the synthesis technology is simple, the prepared complex has a clear structure, the metal complex has amino acid synthesized schiff base ligand, so that the metal complex has latent important application prospect under antineoplastic aspect.
Owner:QINGDAO AGRI UNIV
Symmetrical binuclear ruthenium complex and preparation method utilizing microwave
InactiveCN104231001AShort reaction timeFast heatingLight-sensitive devicesGroup 8/9/10/18 element organic compoundsPyridineCoupling reaction
The invention relates to a symmetrical binuclear ruthenium complex and a preparation method utilizing microwave, belonging to the technical field of synthetic chemistry. The preparation method comprises the following steps: firstly reacting 2-acetylpyridine with 4-bromobenzaldehye as a starting raw material, wherein traditional NaOH and CH3OH are respectively replaced with KOH and EtOH to further shorten reaction time; performing cross-coupling reaction to the obtained terpyridyl compound and diethyl phosphite, wherein the P-H bond in diethyl phosphite is cut off by taking triethylamine as a salt base; then synthesizing an intermediate complex together with ruthenium trichloride hydrate RuCl3.3H2O, and then synthesizing a target product under microwave conditions. The complex molecules can be adsorbed onto a conductive substrate such as an ITO and the like by taking phosphoryl groups at two ends of the complex molecules as fixed ligands and layer-by-layer self assembling can be realized, and the symmetrical binuclear ruthenium complex is an excellent photosensitive dye. The symmetrical binuclear ruthenium complex is simple in design synthesis process and low in cost, and the microwave-assisted synthesis technology is fast and efficient.
Owner:KUNMING UNIV OF SCI & TECH
Chinese yam flavor essence for cigarette popping beads and application of essence in cigarettes
InactiveCN107129866AImprove softness and roundnessImprove fullnessTobacco smoke filtersEssential-oils/perfumesCapric triglyceridesFlavoring essences
The invention belongs to the technical field of cigarette filter production and in particular relates to Chinese yam flavor essence for cigarette popping beads and application of the essence in cigarettes. The Chinese yam flavor essence is composed of Chinese yam extract, 2,3,5-trimethyl pyrazine, vanillin, 2-acetylpyridine, ethyl maltol, bitter almond oil and caprylic capric triglyceride. The Chinese yam flavor cigarette popping beads can be prepared by utilizing the essence, and the popping beads can be added into cigarette filters and can be applied to preparing the cigarette popping beads. By providing specific Chinese yam flavor essence for cigarette popping beads and combining with a perfect popping bead production process, the cigarette popping bead products with stable and uniform forming quality can be prepared. After the popping beads are arranged in the cigarette filters, irritation of the cigarettes can be well weakened, flavor of the cigarettes is improved and enriched, and the flavor enrichment, sensory quality and smoking interestingness of the cigarettes can be obviously improved. Therefore, the Chinese yam flavor essence has high application value and popularization and application significances on design, development, production and sales of the cigarette popping beads.
Owner:CHINA TOBACCO HENAN IND
Preparation method of 2-acetylpyridine
ActiveCN109503469AReduce usageMild reaction conditionsOrganic chemistrySodium bicarbonateDistillation
The invention discloses a preparation method of 2-acetylpyridine. The preparation method comprises the following steps: (1) with 2-picolinic acid as a raw material, adding a first inert solvent and acatalyst, stirring and heating to 55-65 DEG C, dropwise adding a chlorinating agent, heating until a reflux reaction is occured, and performing reduced pressure distillation to obtain 2-pyridinecarbonyl chloride; (2) adding an inorganic salt catalyst, a second inert solvent, an alkaline substance and dialkyl malonate in a reaction bottle, sufficiently stirring, dropwise adding the 2-pyridinecarbonyl chloride, performing a heating reaction, neutralizing with hydrochloric acid, separating out an organic layer, washing with saturated sodium bicarbonate and a saturated salt solution in sequence, drying, and performing vacuum concentration to obtain 2-pyridinecarbonyl Di-tert-Butyl malonate; and (3) adding the 2-pyridinecarbonyl Di-tert-Butyl malonate in a mixed solution of water, organic acidand inorganic acid to perform a reflux reaction, regulating to be neutral with alkaline liquid, extracting with an organic solvent, and performing vacuum concentration to obtain 2-acetylpyridine. Thepreparation method has the advantages of being simple in raw materials, simple in operation, mild in condition, high in yield and small in pollution.
Owner:ZHEJIANG SCI-TECH UNIV
Indium complex taking APT as ligand and having potential leaving group as well as synthesis method and application of the indium complex
InactiveCN110483559AHigh anticancer activityStrong inhibitory activityOrganic active ingredientsGroup 3/13 organic compounds without C-metal linkagesSodium bicarbonateLeaving group
The invention discloses an indium complex taking APT as a ligand and having a potential leaving group as well as a synthesis method and application of the indium complex. The synthesis method comprises the following steps: dissolving 2-acetylpyridine in a mixed solution of methanol and acetonitrile, adding aminothiourea, uniformly mixing the mixture, dropwise adding acetic acid, uniformly mixing the mixture, refluxing the mixed solution, performing vacuum concentration to obtain a concentrate, extracting the concentrate with ethyl acetate, washing a product with saturated sodium bicarbonate and water in order after the extraction step, and carrying out silica gel column chromatography separation to obtain a ligand; adding the ligand obtained in the step 1) and INCl3 into a closed reactionkettle, dropwise adding a mixed solution of methanol and ethanol for dissolving, sealing the reaction kettle after dissolving, and standing the reaction kettle in a vacuum drying oven at 65-80 DEG C for 72 hours to obtain the indium complex. The complex shows good inhibition activity on a cisplatin drug-resistant strain, new data is provided for application of the novel metal-based complex to drug-resistant tumor cell strains, and the synthesis method is simple to operate and convenient to implement.
Owner:GUANGXI NORMAL UNIV
Novel rapeseed oil flavor enhancer and application method thereof in preparation of concentrated-fragrance rapeseed oil
InactiveCN103919102AEasy to buy raw materialsEasy to processEdible oils/fatsFood preparation2-heptenalFuran
The invention relates to a novel rapeseed oil flavor enhancer and an application method thereof in preparation of a concentrated-fragrance rapeseed oil, and belongs to the field of edible oil processing technology. The invention discloses the rapeseed oil flavor enhancer. With 2,5-dimethylpyrazine, hydroxyl acetone, 2-methylpyrazine, isovaleraldehyde, hexaldehyde, 2,3,5-trimethylpyrazine, furfuryl alcohol, 2-methyl-5-ethylpyrazine, 1-methyl-4-cyclohexene, 2-heptenal, 2-methylbutyraldehyde, 2-acetylthiophene, 3-phenyl furan, 2-acetylpyrrole and 2-acetylpyridine as raw materials, the rapeseed oil flavor enhancer is formed through mixing, stirring and canning. The concentrated-fragrance rapeseed oil is prepared by directly adding the novel rapeseed oil flavor enhancer into a rapeseed oil.
Owner:NANJING LONGSHENG VEGETABLE OIL & FAT +1
Method for producing propylene epoxide through propylene epoxidation reaction
ActiveCN103012325BEasy to operateOperational securityOrganic-compounds/hydrides/coordination-complexes catalystsGroup 6/16 element organic compoundsReaction temperatureStructural formula
The invention relates to a method for producing propylene epoxide through propylene epoxidation reaction, which mainly solves the problem that methods for catalyzing epoxidation of styrene by adopting a molybdenum Schiff alkali compound are undisclosed in the previous literatures. According to the method, tert-butyl hydroperoxide and propylene are taken as raw materials and are in contact with a catalyst for 1-12 hours to generate propylene epoxide in the presence of a solvent under the conditions that the reaction temperature is 40-120 DEG C, the reaction pressure is 0.5-5 Mpa and the molar ratio of the tert-butyl hydroperoxide to the propylene is 1:(1-10), wherein the catalyst is a 2-acetylpyridine isonicotinic acid hydrazide molybdenum complex, the chemical structural formula of the 2-acetylpyridine isonicotinic acid hydrazide molybdenum complex is shown in the specification, and the technical scheme that R1 is selected from -OHR2 or R2 is CnH2n+1, and n is 2-10 better solves the problem. The method can be applied to the industrial production of propylene epoxide prepared through propylene epoxidation reaction.
Owner:CHINA PETROLEUM & CHEM CORP +1
Corn essence for food and preparation method thereof
InactiveCN105995910AStrong corn aromaMellow fragranceFood ingredient as taste affecting agentFood ingredient as flavour affecting agentThiazoleEthyl maltol
The present invention relates to a corn essence for food and a preparation method thereof. The corn essence is prepared from the following raw materials: vanillin, ethyl maltol, 2-acetyl pyrazine, dimethyl sulfide, 2-acetyl thiazole, 2-acetylpyridine, tetrahydroquinoxaline, 4-methyl-5-hydroxyethylthiazole, butanedione, and propylene glycol. The corn essence has rich corn aroma, and is mellow in flavor and long in fragrance lasting.
Owner:TIANJIN CHUNYU FOOD INGREDIENTS
A kind of preparation method of doxylamine succinate
The invention relates to a preparation method of doxylamine succinate. The preparation method comprises the steps as follows: firstly, a Grignard reagent generated by iodobenzene and magnesium reacts with 2-acetylpyridine to generate 2-pyridyl phenyl methyl alcohol, the 2-pyridyl phenyl methyl alcohol is recrystallized to be purified, then the 2-pyridyl phenyl methyl alcohol reacts with sodium amide and 2-dimethylamino chloroethane sequentially, doxylamine is obtained and has a salt forming reaction with succinic acid finally, and the doxylamine succinate is obtained. The preparation method is high in reaction efficiency, lower in cost and applicable to industrial mass production.
Owner:JIANGSU LEEWAY BIOLOGICAL TECH
Method for producing propylene epoxide through propylene epoxidation reaction
ActiveCN103012325AEasy to operateOperational securityOrganic-compounds/hydrides/coordination-complexes catalystsGroup 6/16 element organic compoundsReaction temperatureStructural formula
The invention relates to a method for producing propylene epoxide through propylene epoxidation reaction, which mainly solves the problem that methods for catalyzing epoxidation of styrene by adopting a molybdenum Schiff alkali compound are undisclosed in the previous literatures. According to the method, tert-butyl hydroperoxide and propylene are taken as raw materials and are in contact with a catalyst for 1-12 hours to generate propylene epoxide in the presence of a solvent under the conditions that the reaction temperature is 40-120 DEG C, the reaction pressure is 0.5-5 Mpa and the molar ratio of the tert-butyl hydroperoxide to the propylene is 1:(1-10), wherein the catalyst is a 2-acetylpyridine isonicotinic acid hydrazide molybdenum complex, the chemical structural formula of the 2-acetylpyridine isonicotinic acid hydrazide molybdenum complex is shown in the specification, and the technical scheme that R1 is selected from -OHR2 or R2 is CnH2n+1, and n is 2-10 better solves the problem. The method can be applied to the industrial production of propylene epoxide prepared through propylene epoxidation reaction.
Owner:CHINA PETROLEUM & CHEM CORP +1
Tom yum kung essence and preparation method thereof
ActiveCN110419710AStrong fragranceGood aroma coordinationFood scienceAgainst vector-borne diseases1-OcteneAntioxidant
The invention discloses tom yum kung essence and a preparation method thereof. The tom yum kung essence is prepared from the following components: citronella oil, curry oil, lemon oil, cold pressed ginger oil, chili oil, 1-octene-3-alcohol, dimethyl disulfide, tetrahydropyrrole, 2-acetylpyridine, 4-methyl-5-beta-hydroxyethyl thiazole, pyridine, trimethylamine, 2-methyl-3(5 or 6)-methylthiopyrazine, cis-4-heptenal, nutmeg oil, dimethyl sulfide, an anti-oxidizing agent and salad oil. The preparation method of the tom yum kung essence comprises the steps that the citronella oil, the curry oil, the lemon oil, the cold pressed ginger oil, the chili oil, the 1-octene-3-alcohol, the dimethyl disulfide, the tetrahydropyrrole, the 2-acetylpyridine, the 4-methyl-5-beta-hydroxyethyl thiazole, the pyridine, the trimethylamine, the 2-methyl-3(5 or 6)-methylthiopyrazine, the cis-4-heptenal, the nutmeg oil, the dimethyl sulfide and the anti-oxidizing agent are weighed and added to the salad oil, andthe mixture is stirred evenly to get the tom yum kung essence.
Owner:广州馨杰添加剂有限公司
Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone
The invention relates to a preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone, which adopts nucleophilicity organic small-molecular catalyst as a catalyst, 2 - amino -3-hydroxypyridine and 2 - acetyl pyridine have cyclization reaction according to a chemical measurement ratio to obtain 3 - (2 - hydroxyethyl) -9-- hydroxy -2-- Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4-ketone, then the 3 - (2 - hydroxyethyl) -9-- hydroxy -2-- Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4-ketone is catalyzed and hydrogenated to obtain diol intermediate 3 - (2 - hydroxyethyl) -6,7,8,9 - tetrahydro-9 - hydroxy -2-- Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4-ketone, and then primary hydroxyl group is selectively chloridized to obtain Paliperidone intermediate: 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone. Compared with the prior art, the method has the advantages of low cost, small environmental pollution, high selectivity and the like.
![Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone](https://images-eureka.patsnap.com/patent_img/71277bdf-bab6-42db-ab4c-887e0bccc6e7/B2009100499856D0000011.PNG "Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone")
![Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone](https://images-eureka.patsnap.com/patent_img/71277bdf-bab6-42db-ab4c-887e0bccc6e7/B2009100499856D0000021.PNG "Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone")
![Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone](https://images-eureka.patsnap.com/patent_img/71277bdf-bab6-42db-ab4c-887e0bccc6e7/B2009100499856D0000022.PNG "Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone")
Owner:SHANGHAI TWISUN BIO PHARM
2-pyridyl benzimidazole palladium copper heteronuclear compound and its preparation method and application
InactiveCN104402943BEasy to synthesizeReduce dosageOrganic chemistryOrganic-compounds/hydrides/coordination-complexes catalystsChemical compoundQuinoline
The invention relates to a 2-pyridyl benzimidazole palladium copper heteronuclear compound, the general formula of which is shown as the specification. Specifically, X is Cl<->, Br<-> or I<->; L is a tertiary phosphine ligand; P is a diphosphine ligand; R and R1 can be -H, -CH3, -C2H5 or -OCH3; and R is at any position of aromatic ring 7-10, and R1 is at any position of pyridine ring 3-5. The compound can serve as a bimetallic catalyst to catalyze the three-component reaction of 2-acetylpyridine, 2-amino halogenated benzylalcohol and arylboronic acid so as to synthesize a 2-pyridyl quinoline derivative.
Owner:LUOYANG NORMAL UNIV
Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone
The invention relates to a preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone, which adopts nucleophilicity organic small-molecular catalyst as a catalyst, 2 - amino -3-hydroxypyridine and 2 - acetyl pyridine have cyclization reaction according to a chemical measurement ratio to obtain 3 - (2 - hydroxyethyl) -9-- hydroxy -2-- Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4-ketone, then the 3 - (2 - hydroxyethyl) -9-- hydroxy -2-- Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4-ketone is catalyzed and hydrogenated to obtain diol intermediate 3 - (2 - hydroxyethyl) -6,7,8,9 - tetrahydro-9 - hydroxy -2-- Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4-ketone, and then primary hydroxyl group is selectively chloridized to obtain Paliperidone intermediate: 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone. Compared with the prior art, the method has the advantages of low cost, small environmental pollution, high selectivity and the like.
![Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone](https://images-eureka.patsnap.com/patent_img/09583954-48d7-40fb-9769-5bc2be3c17cc/FSB00000748092100011.PNG "Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone")
![Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone](https://images-eureka.patsnap.com/patent_img/09583954-48d7-40fb-9769-5bc2be3c17cc/G2009100499856D00011.PNG "Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone")
![Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone](https://images-eureka.patsnap.com/patent_img/09583954-48d7-40fb-9769-5bc2be3c17cc/G2009100499856D00021.PNG "Preparation method of 3-(2-chloroethyl)-6, 7, 8, 9 - tetrahydro-9 - hydroxy - 2 - Methylenetetrahydrofolate - pyrido [1,2-alpha] pyrimidine -4 - ketone")
Owner:SHANGHAI TWISUN BIO PHARM
The method of styrene epoxidation reaction
ActiveCN103012323BEasy to operateOperational securityOrganic chemistryOrganic-compounds/hydrides/coordination-complexes catalystsStyrene oxideReaction temperature
The invention relates to a styrene epoxidation reaction method, which mainly solves the problem that methods for catalyzing epoxidation of styrene by adopting a molybdenum Schiff alkali compound are undisclosed in the previous literatures. According to the method, tert-butyl hydroperoxide and styrene are taken as raw materials and are in contact with a catalyst for 1-24 hours to generate styrene oxide in the presence of a solvent at an ordinary pressure under the conditions that the reaction temperature is 30-120 DEG C, and the molar ratio of the tert-butyl hydroperoxide to the styrene is (1-20):1, wherein the catalyst is a 2-acetylpyridine o-aminophenol molybdenum complex, the chemical structural formula of the 2-acetylpyridine o-aminophenol molybdenum complex is shown in the specification, and in the formula, R is selected from -OHR2 or R2 is CnH2n+1, and n is 2-10. The method can be applied to the industrial production of styrene oxide prepared through styrene epoxidation reaction.
Owner:CHINA PETROLEUM & CHEM CORP +1
2-acetylpyridine benzoyl hydrazine molybdenum complex and preparation method thereof
ActiveCN103012489AEasy to operateOperational securityOrganic-compounds/hydrides/coordination-complexes catalystsGroup 6/16 element organic compoundsHydrazine compoundMolybdenum
The invention relates to a 2-acetylpyridine benzoyl hydrazine molybdenum complex and a preparation method thereof, mainly solving the problem that a molybdenum Schiff alkali coordination compound is undisclosed in previous patents. The technical scheme of the invention is adopted to solve the problem, and in the technical scheme, the chemical structural formula of the 2-acetylpyridine benzoyl hydrazine molybdenum complex is shown in the specification, wherein R1 is selected from -OHR2 or R2 is CnH2n+1, and n is 2-10. The preparation method can be applied to the industrial production of the 2-acetylpyridine benzoyl hydrazine molybdenum complex.
Owner:CHINA PETROLEUM & CHEM CORP +1
Organic white light material o-pyridine p-benzene bis(imino) cadmium/mercury complex and preparation method thereof
ActiveCN103265945BImprove stabilitySimple methodGas discharge lamp usageLuminescent compositionsBenzeneFluorescence
The invention provides an organic white light material o-pyridine p-benzene bis(imino) cadmium / mercury complex and a preparation method thereof, relates to an organic light-emitting material and a preparation method therefore, and aims at solving the problems of the conventional white light-emitting material that the synthesis process is complex, the yield is low and the service life of fluorescence is short. The organic white light material consists of an o-pyridine p-benzene bis(imino) cadmium complex [N, N'-bis(2-acetylpyridine methylene) benzene-1, 4-diamine] CdCl2 and an o-pyridine p-benzene bis(imino) mercury complex [N, N'-bis(2-acetylpyridine methylene) benzene-1, 4-diamine] HgCl2. The preparation method comprises the following steps of: 1, dissolving N, N'-bis(2-acetylpyridine methylene) benzene-1, 4-diamine and CdCl2 or HgCl2 into methanol, and heating and refluxing; 2, filtering turbid reaction liquid and collecting solid powder; and 3, washing with methanol to obtain the organic white light material. The preparation method is simple in synthetic process, the yield can be up to more than 60%, and the service life of fluorescence is relatively long.
Owner:湖南哈工机器人研究院有限公司
2-Acetylpyridine adenoaminophenol molybdenum complex and preparation method thereof
ActiveCN103012487BEasy to operateOperational securityOrganic-compounds/hydrides/coordination-complexes catalystsGroup 6/16 element organic compoundsStructural formulaMolybdenum
The invention relates to a 2-acetylpyridine o-aminophenol molybdenum complex and a preparation method thereof, mainly solving the problem that a molybdenum Schiff alkali coordination compound is undisclosed in previous patents. The technical scheme of the invention is adopted to solve the problem, and in the technical scheme, the chemical structural formula of the 2-acetylpyridine o-aminophenol molybdenum complex is shown in the specification, wherein R1 is selected from -OHR2 or R2 is CnH2n+1, and n is 2-10. The preparation method can be applied to the industrial production of the 2-acetylpyridine o-aminophenol molybdenum complex.
Owner:CHINA PETROLEUM & CHEM CORP +1
2-acetylpyridine isonicotinic acid hydrazide molybdenum complex and preparation method thereof
ActiveCN103012488BEasy to operateOperational securityOrganic-compounds/hydrides/coordination-complexes catalystsGroup 6/16 element organic compoundsStructural formulaIsonicotinic acid
The invention relates to a 2-acetylpyridine o-aminophenol molybdenum complex and a preparation method thereof, mainly solving the problem that a molybdenum Schiff alkali coordination compound is undisclosed in previous patents. The technical scheme of the invention is adopted to solve the problem, and in the technical scheme, the chemical structural formula of the 2-acetylpyridine isonicotinyl hydrazide molybdenum complex is shown in the specification, wherein R1 is selected from -OHR2 or R2 is CnH2n+1, and n is 2-10. The preparation method can be applied to the industrial production of the 2-acetylpyridine isonicotinyl hydrazide molybdenum complex.
Owner:CHINA PETROLEUM & CHEM CORP +1
Fishy flavor agent for feed and preparation method of fishy flavor agent
The invention discloses a fishy flavor agent for a feed and a preparation method of the fishy flavor agent. The fishy flavor agent contains the following perfume materials in percentage by weight: 0.5-2% of glycine betaine, 1-3% of trimethylamine, 0.1-2% of 2-methyl-3-sulfydrylfuran, 0.1-1% of pyrrolidine, 0.1-1% of piperidine, 0.1-2% of phenylethylamine, 0.01-1% of 2-acetylpyridine, 0.1-1% of furanone, 1-3% of ethyl maltol, 1-3% of 2-acetylpyrazine, 1-3% of 2,3,5-trimethylpyrazine, 0.01-2% of 3-methylthiopropanal, 30-70% of fishy smell reactants and 10-60% of glycerol triacetate. The fishy flavor agent is prepared by carrying out enzymolysis on animal wastes, then adding reducing sugars to carry out Maillard reaction, and then, adding artificial synthetic essence to blend. The fishy flavor agent has the advantages that the animal wastes are reasonably utilized, the preparation process is simple, and the product is strong in fragrance, stable and easy to store.
Owner:成都大帝汉克生物科技有限公司
2-Acetylpyridine benzohydrazide molybdenum complex and preparation method thereof
ActiveCN103012489BEasy to operateOperational securityOrganic-compounds/hydrides/coordination-complexes catalystsGroup 6/16 element organic compoundsStructural formulaHydrazide
Owner:CHINA PETROLEUM & CHEM CORP +1
A kind of probe and its preparation method and application
The invention discloses a probe and a preparation method and application thereof. The preparation method includes mixing and stirring 4-bromobenzaldehyde, 2-acetylpyridine, 4-vinyl pyridine, brominated alkanes, ammonium hydroxide, palladium acetate, triphenyl phasphine, triethylamine and DMF (dimethylformamide) prior to reflux, stirring for 1 hour at a room temperature to obtain a precipitate, filtering and recrystallizing in acetic acid so as to obtain a reactant; taking the reactant out, cooling the reactant to the room temperature to generate a precipitate, filtering to obtain a solid and drying the solid so as to obtain the probe. The probe is capable of quantitatively analyzing Zn<2+> concentration in a solution and has the advantages of low quantitative analysis concentration, high anti-interference capability, simplicity in operation, visual results and simplicity and convenience in analysis.
Owner:GUIZHOU UNIV
Catalyst for terpolymerization of norbornene, acrylate and octafluorocyclopentene and ternary copolymerization method
Owner:NINGBO UNIVERSITY OF TECHNOLOGY
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