57 results about "3-phenylpropionic acid" patented technology

This invention provides methods and devices for spatially separating at least first and second components in a sample which in one exemplary embodiment comprises introducing the first and second components into a first microfluidic channel of a microfluidic device in a carrier fluid comprising a spacer electrolyte solution and stacking the first and second components by isotachophoresis between a leading electrolyte solution and a trailing electrolyte solution, wherein the spacer electrolyte solution comprises ions which have an intermediate mobility in an electric field between the mobility of the ions present in the leading and trailing electrolyte solutions and wherein the spacer electrolyte solution comprises at least one of the following spacer ions MOPS, MES, Nonanoic acid, D-Glucuronic acid, Acetylsalicyclic acid, 4-Ethoxybenzoic acid, Glutaric acid, 3-Phenylpropionic acid, Phenoxyacetic acid, Cysteine, hippuric acid, p-hydroxyphenylacetic acid, isopropylmalonic acid, itaconic acid, citraconic acid, 3,5-dimethylbenzoic acid, 2,3-dimethylbenzoic acid, p-hydroxycinnamic acid, and 5-br-2,4-dihydroxybenzoic acid, and wherein the first component comprises a DNA-antibody conjugate and the second component comprises a complex of the DNA-antibody conjugate and an analyte.

The invention discloses a chiral MOF-graphene hybrid material, a preparation method thereof, and the application of the chiral MOF-graphene hybrid material to the detection of chiral drug enantiomers, and belongs to the technical fields of nanometer composite materials, macromolecule-based composite materials, graphene-based composite materials and chiral sensing detection. The method comprises the following main steps: blending an alkaline aqueous solution of L-aspartic acid and an aqueous solution of cupric nitrate-graphene oxide, adding an ethanol solution of 4, 4'-bipyridine, leaving the mixture to stand over a night, performing centrifugal separation, washing and drying, so as to obtain the chiral MOF-graphene hybrid material. A chiral MOF-graphene hybrid material sensor constructed through the hybrid material is applied to the sensitive detection of the contents of R-2-amino-3-phenylpropionic acid and S-2-amino-3-phenylpropionic acid enantiomers.

The invention relates to new compounds, 3-phenylpropionic acid derivatives of formula (I) wherein W represents COOH group or its bioisosters, or —COO—C₁-C₄-alkyl group; Y represents NH, N—C₁-C₁₀-alkyl, O, or S; X represents O, S, NH, N—C₁-C₁₀-alkyl, N-aryl, NSO₂—C₁-C₁₀-alkyl, N—SO₂-aryl, or N—SO₂-heteroaryl; R₁ to R₈ each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.

The invention discloses a 2-carbonyl-3-phenylpropionic acid p-methyl benzoyl hydrazone bis-n-butyl tin complex. The complex has the structural formula (I) shown in the specification, wherein Ph is phenyl, and R is n-butyl. The invention further discloses a preparation method of the 2-carbonyl-3-phenylpropionic acid p-methyl benzoyl hydrazone bis-n-butyl tin complex and application in preparation of anti-cancer drugs.

The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO—C₁-C₄-alkyl group; Y represents NH, N—C₁-C₁₀-alkyl, O, or S; Z represents NH, N—C₁-C₁₀-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C₁-C₁₀-alkyl, N-aryl, NSO₂—C₁-C₁₀-alkyl, N—SO₂-aryl, or N—SO₂-heteroaryl; R₁, to R₆ each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.

The invention discloses a 2-carbonyl-3-phenylpropionic acid p-nitrobenzoyl hydrazone di-p-methyl benzyl tin complex of which the structural formula is shown in the description; in the formula, Ph is phenyl, and R is methyl benzyl. The invention further discloses a preparation method and application of the 2-carbonyl-3-phenylpropionic acid p-nitrobenzoyl hydrazone di-p-methyl benzyl tin complex in preparation of anti-cancer medicines.

The invention discloses a 2-carbonyl-3-phenylpropionic acid benzoyl hydrazone di-n-butyltin complex. The 2-carbonyl-3-phenylpropionic acid benzoyl hydrazone di-n-butyltin complex is a complex with the structural formula (I) (please see the formula (I) in the description), wherein Ph is phenyl, and R is n-butyl. The invention further discloses a preparation method of the 2-carbonyl-3-phenylpropionic acid benzoyl hydrazone di-n-butyltin complex and application of the 2-carbonyl-3-phenylpropionic acid benzoyl hydrazone di-n-butyltin complex to anti-cancer drug preparation.

The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO—C₁-C₄-alkyl group; Y represents NH, N—C₁-C₁₀-alkyl, O, or S; Z represents NH, N—C₁-C₁₀-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C₁-C₁₀-alkyl, N-aryl, NSO₂—C₁-C₁₀-alkyl, N—SO₂-aryl, or N—SO₂-heteroaryl; R₁ to R₈ each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.

The present invention relates to a process for preparing enantiomerically enriched, optionally substituted 2-alkoxy-3-phenylpropionic acids by asymmetrically hydrogenating alkoxycinnamic acids.

The invention discloses a novel phenylisoserine derivative: (2R, 3S)-3-(tert-butoxycarbonylamino)-2(2-ethoxypropene-2-oxo)-3-phenylpropionic acid as a side chain for the synthesis of docetaxel, and a preparation method for the compound. The preparation method includes the following steps that: (2R, 3S)2-hydroxy-3-amino phenylalanine methylester is prepared with (3R, 4S)3-hydroxy-4-phenylazetidine-2-ketone ring-opening product, the amino group is protected by the tert-butoxycarbonyl group, the hydroxyl group is protected by the 2-ethoxypropene group, the methyl ester is unshackled, and thereby the novel phenylisoserine derivative is obtained. The invention also discloses a midbody compound which is prepared with the compound and used for synthesizing docetaxel, and a preparation method for the midbody compound. The novel synthesis route for synthesizing docetaxel has the advantages of mild reaction conditions and high condensation efficiency, can be used for industrialized production, and can be widely popularized.

The present invention provides one kind of process of resolving optical isomer of 2-hydroxymethyl-3-phenyl propionic acid. By using glucooctylamine as resolving agent, racemized 2-hydroxymethyl-3-phenyl propionic acid forms two diastereomers in certain solvent. Through separation, re-crystallization and acid or alkali liberation, one diastereomer with relatively low dissolubility is obtained. The resolving solvent is methanol, ethanol, isopropanol, acetone, etc or their mixed solvent with water. The process has high resolving efficiency, facile resolving agent and easy recovery of resolving agent, and is suitable for industrial production.

The invention provides corrosion inhibitor for carbon steel in the oil field acid environment, and particularly relates to preparation and application of low-toxicity and efficient corrosion inhibitor for restraining corrosion of carbon steel and products of the carbon steel in oil field acid pickling liquid or a saturated CO2 medium. According to the preparing method of the corrosion inhibitor, 3-phenylpropionic acid and diethylenetriamine are subjected to the dehydration reaction, and the phenylpropionic acid imidazoline ramification is obtained. According to the product, comprehensive corrosion and local corrosion is prevented from being generated in the process that the carbon steel makes contact with the acid pickling liquid or the CO2 medium. The compound does not serve as metal corrosion inhibitor at current. By adoption of the corrosion inhibitor, production is simple and convenient, toxicity is small, the inhibition rate is high, corrosion damage to the carbon steel from the acid pickling liquid or CO2 can be effectively restrained, and wide application prospects are achieved. The steps are simple, operation is convenient, and practicability is high.

The invention provides a synthesis method of 1, 8-diazabicycle. According to the technical scheme, a synthesis route of DBU is innovatively designed. Specifically, the method comprises the steps of firstly, reacting epsilon caprolactam, acrylonitrile and hydroquinone to generate N-(beta-cyanoethyl)-epsilon caprolactam, on the basis, reacting the N-(beta-cyanoethyl)-epsilon caprolactam with p-toluenesulfonic acid under a catalytic condition, then carrying out ice bath, reacting the N-(beta-cyanoethyl)-epsilon caprolactam with benzyl chloride under the protection of nitrogen, reacting the obtained product with sodium perborate by taking EDTA as a catalyst, and mixing a reaction product with 3-phenylpropionic acid and then reacting the mixture with 4-nitrochlorobenzyl to obtain the product; filtering the reaction product, extracting the filtrate with ethyl acetate after filtering, performing solid-liquid separation, merging solid phases, and drying the solid phases under reduced pressureto obtain the final product. According to the method, a brand-new synthetic route is adopted, the reaction condition is mild, the cost of raw materials is low, and the method has quite high popularization prospect.

Provided is an aromatic composition containing, as active ingredients, a fragrance substance of Ficus carica L. analyzed by the solid-phase microextraction (SPME) method, and a 3-phenylpropionic acid which is warm, balsamic, and has a sweet fragrance, thereby reproducing the unique fragrance of Ficus carica L. and having excellent palatability.

The invention relates to the field of viscosity reduction of thickened oil and specifically relates to a viscosity reducer for low-temperature eutectic thickened oils, a preparation method and application thereof. The viscosity reducer for low-temperature eutectic thickened oil in the invention is prepared according to the step of stirring and heating choline chloride and 3-phenylpropionic acid for 1-3h in oil bath at 80-100 DEG C till the reaction mixture is transparent liquid. Compared with common surfactant viscosity reducers, polymer viscosity reducers and oil-soluble viscosity reducers inother markets, the viscosity reducer for low-temperature eutectic thickened oils has the advantages of low raw material cost, simple synthesis operation, environmental protection, no toxicity, obvious effect in viscosity reduction of thickened oil and excellent viscosity reduction property under high temperature. The viscosity reducer for low-temperature eutectic thickened oil has a potential market value.

The invention discloses a carbonyl reductase with a self-assembled interface, and application of the same in synthesis of (R)-3-hydroxy-3-phenylpropionic acid ethyl ester. The carbonyl reductase withthe self-assembled interface is prepared by using the following steps: adding carbonyl reductase to a Tirs-HCl buffer, adding a toluene solution of polystyrene, shaking in a shaking bed for 1-4 hoursin the dark at 40-100 r/min and 20-40DEG C, and centrifuging to obtain a reaction system in which an organic phase is at the upper layer, the carbonyl reductase with the self-assembled interface is atthe middle layer, and an aqueous phase is at the lower layer; and washing the middle layer with toluene and Tirs-HCl buffer to obtain the carbonyl reductase with the self-assembled interface. The carbonyl reductase with the self-assembled interface, constructed in the invention, has the relatively good catalytic function at the interface between the organic phase and the aqueous phase, and can beused for converting 3-hydroxy-3-phenylpropionic acid ethyl ester to (R)-3-hydroxy-3-phenylpropionic acid ethyl ester, wherein the enantiomer excess value of (R)-3-hydroxy-3-phenylpropionicacidethylester is greater than 99%.

A compound selected from the group consisting of (a) optically active 2-hydroxymethyl-3-phenylpropionic acid cis-1-amino-2-indanol salt, (b) optically active 2-hydroxymethyl-3-phenylpropionic acid alpha -methylbenzylamine salt, (c) optically active 2-hydroxymethyl-3-phenylpropionic acid 3-methyl-2-phenyl-1-butylamine salt, (d) a salt of (S)-2-hydroxymethyl-3-phenylpropionic acid with (1R, 2S)-(+)-cis-1-amino-2-indanol, (e) a salt of (R)-2-hydroxymethyl-3-phenylpropionic acid with (1S, 2R)-(-)-cis-1-amino-2-indanol, (f) a salt of (R)-2-hydroxymethyl-3-phenylpropionic acid with (S)-(-)- alpha -methylbenzylamine, (g) a salt of (S)-2-hydroxymethyl-3-phenylpropionic acid with (R)-(+)- alpha -methylbenzylamine, (h) a salt of (S)-2-hydroxymethyl-3-phenylpropionic acid with (S)-(-)-3-methyl-2-phenyl-1-butylamine, and (i) a salt of (R)-2-hydroxymethyl-3-phenylpropionic acid with (R)-(+)-3-methyl-2-phenyl-1-butylamine.

The invention relates to a treating agent for removing ethyl alcohol, isopropyl alcohol and octyl alcohol in waste water of an amino resin workshop. The treating agent is formed by compounding 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane, 1,8-dihydroxy-3-methoxy-6-methylanthraquinone, S(-)-2-amino-6-n-propyl-4,5,6,7-tetrahydrobenzothiazole hydrochloride, 4-octylphenol ethoxylate, 3',4'-dihydroxy-2-(methyl amino)acetophenone hydrochloride, 4-acetoxy-3-methoxy-(2-allyl) benzene, acetic acid-4-methoxy-benzyl ester, 6,6,10-trimethylbicyclo-3,1,1-hep-2-ene, 2-[[1-(3-acethythio-2-methypropionyl)pyrrolidine-2-formyl]amino]-3-phenylpropionic acid and the like. The capacity of the treating agent for complexing with a target substance is high, the complex precipitate forming speed is high, and the removing rate can reach 99.9%.

The invention provides a carboxyl-containing difluoro monomer, a preparation method of the difluoro monomer and application of the difluoro monomer to preparation of carboxyl-containing polyarylether, and belongs to the technical field of difluoro monomers and preparation of the difluoro monomers. The preparation method comprises the following steps: under argon atmosphere, using 2,6-difluorobenzoic acid as a raw material, thionyl chloride as a solvent and a reactant, and N,N-dimethylformamide as a catalyst to prepare 2,6-difluorobenzoyl chloride; under argon atmosphere and anhydrous condition, using anhydrous aluminium trichloride, 2,6-difluorobenzoyl chloride and 3-phenylpropionic acid as raw materials to prepare the white crystal difluoro monomer, namely, 3-[4-(2,6-difluorobenzoyl) phenyl] propionic acid. Compared with the common polyarylether polymer, the carboxyl-containing polyarylether prepared and synthesized in the invention introduces ionizable polar groups, can be applied to membrane separation technology, and can be used for promoting the hydrophilic performance and anti-fouling performance of a water separation membrane and improving the conductivity of a proton exchange membrane due to the electronegative carboxyl.