The invention discloses a method for preparing nano-alloy droplets by laser irradiation, which belongs to the technical field of liquid metal, and comprises the following steps: S1, pre-dispersing the liquid metal, placing the pre-dispersed liquid metal in an organic solvent to obtain Liquid metal / organic solvent precursor; S2, introduce non-focused laser into the liquid metal / organic solvent precursor prepared in S1, and conduct laser radiation evaporation under agitation; S3, system after laser evaporation to S2 under agitation Into a mixed gas containing oxygen to promote the generation of the passivation layer; S4, after the passivation layer is generated, concentrate or separate to make nano-alloy droplets; the nano-droplets prepared by the preparation method provided by the invention are uniform in composition, The size structure is controllable, and the surface is highly modifiable without ligands, which provides a method for preparing basic materials for applications in the fields of flexible electronics, photocatalysis, and nanomedicine.