64results about How to "Activity has no effect" patented technology

The invention belongs to the technical field of medicines, and particularly relates to compounds which are shown as a general formula I and in which pyrrolopyrimidone is taken as a parent nucleus or salts thereof, a method for preparing the compounds, a composition, and use of the compounds as dipeptidyl peptidase-IV (DPP-IV) inhibitors in the prevention or treatment of diseases which benefit from DPP-IV inhibition. The preparation process for the compounds is simple, raw materials are readily available, and the method is suitable for industrialized production; through in-vitro experiments, the compounds have a good effect of selectively inhibiting DPP-IV, and almost do not affect the activities of DPP-VIII and DPP-IX when the activity of the DPP-IV is effectively inhibited; and the compounds are expected to have low toxicity after being developed into medicines, and have outstanding advantages.

The invention discloses a titanium-based nano-composite metal oxide catalyst and a preparation method thereof, belonging to the technical field of control on exhaust contaminants in diesel engine tail gas. In the invention, the titanium-based nano-composite metal oxide catalyst is prepared by taking TiO2 as a carrier and taking metal oxides (VOx, MnOx and CeOx) as active components by adopting a self-propagating high-temperature synthesis (SHS) method, wherein the molar percentage of the TiO2 is 80-95%, the molar percentage of the VOx is 2-20%, the molar percentage of the MnOx is 2-10%, and the molar percentage of the CeOx is 2-10%. The preparation method of the titanium-based nano-composite metal oxide catalyst comprises the following steps of: preparing a TiO(NO3)2 precursor solution; determining the loads of the active components of the metal oxides; preparing a precursor solution of the active components of the metal oxides; and preparing the catalyst by SHS. The catalyst preparedby the method disclosed by the invention has the advantages of large specific surface area, large pore volume, proper pore size distribution and low degree of crystallization, all active species are highly dispersed and are interactive, the catalyst has higher NOx removing rate and N2 selectivity in a wide temperature window at 100-450 DEG C, and the catalyst has strong anti-sulfur and anti-waterpoisoning performance and is suitable for treating NOx in diesel engine tail gas of automobiles and ships.

The invention relates to a hybrid pyrimido ketone DPP-IV inhibitor shown as a formula I as well as salts, a preparation method, compounds and application thereof in the prevention or treatment of diseases that benefit from the DPP-IV inhibitor. A preparation process of the DPP-IV inhibitor is simple, easily-obtained in raw materials and suitable for industrial large-scale production; and in-vitro and in-vivo experiments verify that the DPP-IV inhibitor has very good selective inhibition effect to DPP-IV, nearly has no influence on activities of DPP-VIII and DPP-IX at the same time of effectively inhibiting the DPP-IV activity, lower toxicity after prepared medicine development, stronger effect and longer acting time compared with the effect of a medicine Alogliptin with the same mechanism and shows excellent effects of reducing the blood sugar and increasing the insulin sensitivity. The formula I is shown as follows.