The invention relates to equipment for making biological tissue specimen paraffin sections, in particular to a rapid pathological tissue dehydrating machine. The rapid pathological tissue dehydrating machine comprises a machine box body and an intelligent operating table. A specimen treating box, a paraffin box, a vacuum pump, a plurality of reagent barrels and an ultrasonic generator are arranged in the machine box body, a microwave cavity is formed in the specimen treating box, a microwave source is connected to the microwave cavity, and the specimen treating box is connected with the paraffin box, the reagent barrels and the vacuum pump through pipeline assemblies. The rapid pathological tissue dehydrating machine integrates microwave treatment, ultrasonic treatment and vacuum treatment and cooperates with special reagents, traditional tissue treating time can be shortened to 20 min-3 h from 16 h-22 h, the procedures of immobilizing, dehydrating, transparentizing, wax impregnating, section making and diagnosing can be completed within 2 h after a small specimen is delivered, pathological diagnosis can be made within 32 h after a radical cure specimen is delivered, time of waiting for disease diagnosis is shortened for patients, anxiety is relieved, and especially time is saved for patients needing to receive special treatment such as surgery or targeted therapy; the length of stay is reduced for patients, and hospitalization expenses are reduced; meanwhile, the economic benefits of hospitals are increased.