The invention discloses a 2-3D
image registration algorithm for CT and X-
Ray of a target area, and the
algorithm comprises the following steps: S1, shooting preoperative CT image data, segmenting a
rigid structure near the target area, and carrying out the CT preprocessing of an image; s2, X-
ray images of c-arm at different angles of the corresponding parts of the patient are shot, and meanwhile, c-arm internal reference and pre-
processing images are obtained; s3, registering the rigid structures on the X-
ray based on the plurality of rigid structures segmented on the CT, and outputting a plurality of rigid registration parameters; and S4, marking a target area on the CT by a doctor, constructing a model based on the plurality of rigid registration parameters, the X-
ray and the CT image, and predicting the position of the target area in the operation under the c-arm coordinate
system based on the constructed model. According to the invention, the registration efficiency and the registration precision can be improved; the iteration convergence speed is accelerated, and the
algorithm application scene is improved.