The invention relates to a peach-pit-based method for preparing leaf fertilizer for preventing and controlling peach tree leaf shrinkage, and belongs to the technical field of fertilizer preparation. The method comprises the following steps: firstly, immersing peach pits with a sodium chloride solution, taking out the peach pits, inserting the peach pits into culture soil for culture till germs appear on the surfaces of the peach pits, using the peach pits for spare, smashing substances such as cyanotis arachnoidea, tender leaves of the peach trees and the like, screening the smashed substances, and mixing the smashed substances with distillers' grains; then adjusting pH with a sodium hydroxide solution, performing heating, stirring and standing, mixing the pH adjusted solution with distilled water, performing centrifugal separation, collecting supernate, injecting the supernate into peach pits for seal treatment, taking the peach pits out for grinding and filtration, collecting filtration liquid and filtration matter respectively, smashing and screening the filtration matter, obtaining powder, mixing the obtained powder with the filtration liquid, and sterilizing and disinfecting the mixture. The method has the benefits that the peach tree leaf shrinkage is effectively prevented and controlled, and chemical residual and damage to the human body health are prevented; growth vigor of peach trees is promoted, and an effect on enhancement of nutrients for the peach trees is achieved; preparation steps are simple, and the cost is low.