The invention discloses reel-to-reel equipment for preparing a nano-silver wire electrode film. The reel-to-reel equipment comprises a vacuum chamber, a first unwinding roller, a first winding roller, a second unwinding roller, a second winding roller, a nano-silver wire groove mold, a Meyer rod group, a high-molecular polymer groove mold, an impressing roller, a separating roller and a coating roller, and the unwinding rollers and the winding rollers are both arranged in a roller replacing device. According to the device, replacement of the rollers can be achieved under the condition that the vacuum chamber is not exposed to the atmosphere. A PI flexible film coiled material is loaded on the first unwinding roller, and the coating roller, the MeiYer rod group, the impressing roller, a nano-silver wire recycling pool and the first winding roller are sequentially arranged on the downstream portion of the first unwinding roller. A PET flexible film coiled material is loaded on the second unwinding roller, and the high-molecular polymer groove mold, the impressing roller, the separating roller and the second winding roller are sequentially located on the downstream of the second unwinding roller. The PI flexible film and the PET flexible film are subjected to impressing compounding at the impressing roller and an impressing supporting roller, are separated at the separating roller and are finally wound by the first winding roller and the second winding roller respectively.