The invention belongs to the technical field of hangover-alleviating Chinese herbal medicines, and discloses a hangover-alleviating and liver-protecting composition and a preparation method thereof. The composition takes fructus alpiniae oxyphyllae as a monarch drug, and the fructus alpiniae oxyphyllae is warm in nature to spleen and kidney meridians and is used for regulating the problem of spleen and stomach disharmony caused by alcohol, warming spleen and kidney, reducing vomiting and further reducing gastric acid secretion; radix puerariae and hovenia acerba are taken as ministerial drugs, are sweet in taste and have the effects of relieving alcoholism, quenching thirst due to yin deficiency and diarrhea due to spleen deficiency, protecting and nourishing the liver and preventing alcoholism; lophatherum gracile can clear heat and purge fire, Chinese olive can help produce saliva and slake thirst, orange peel can regulate middle energizer and tonify spleen, fingered citron and bunge cherry seed can soothe liver and digest, and perilla can accelerate gastrointestinal digestion and promote metabolism; the composition is used as assistant and guide medicines, mainly regulates spleen, stomach and liver meridians, and jointly plays the roles of dredging triple jiao, promoting depression, expelling liver toxin, protecting intestines and stomach, and dispelling the effects of alcohol and protecting liver. According to the preparation method, stir-frying and crushing are adopted, so that the analysis rate of effective components in subsequent decoction is increased, the maximum degree of drug effect fusion is realized, the drug effect is ensured, no toxic or side effect is generated, and the content of the effective components in the finished product is lower than the LD50 standard amount of intragastric administration of mice.