The invention discloses a production process of a winding layer of a logging signal cable, and relates to the field of signal cables. The production process comprises the steps of firstly uniformly mixing nano-titanium dioxide modified polyvinyl chloride, polystyrene, corundum modified polycarbonate and isoprene rubber, putting the mixture into a high-speed mixer to mix, then adding a urea solution, putting the mixed solution into a closed environment filled with the mixture of hydrogen and nitrogen, filtering after standing, dissolving the precipitate in a calcium chloride solution, placing the solution in a water bath with the temperature being 35-45 DEG C, adding coconut oil fatty acid diethanolamide, dicumyl peroxide, zinc oxide and 2-methyl methacrylate into the solution, finally adding viscose fibers, nano-aluminum oxide and methyl methacrylate- n-butyl acrylate-sodium allylsulfonate, putting the mixture in sesame oil saturated vapor pressure for fumigation, recycling ethyl alcohol and sesame oil by vacuum concentration, and delivering the mixture to an extruding machine for extrusion molding. The prepared winding layer of the logging signal cable is high in strength, toughness and bending resistance, good in corrosion resistance and long in service life.