30 results about "Bone function" patented technology

The present invention relates to a bone polypeptide, particularly bone polypeptide-1 and nucleic acid molecules encoding the same. The present invention provides the human primary sequence of bone polypeptide-1 as well as sequences of vertebrate homologs. The invention also provides cell lines engineered to express the cDNA, antibodies to detect its translation products, and recombinant adenoviruses to deliver an expressible cDNA into a host. Bone polypeptide-1 can be utilized to treat diseases affecting renal and bone functions.

A survivability and safety unit (also referred to as a safety unit) can be worn in high contact activities to minimize injuries and help prevent quadriplegic injuries and concussions. The safety unit of the present invention provides synthetic muscle and skeleton frame, strength and resistance enhancement. The safety unit of the present invention can replicate muscle and bone function as a kinematic device. It can withstand high velocity impacts, it dampens the impact load and extends the shock absorption distribution.

The invention mainly relates to a soft capsule helpful for increasing bone density and a preparation method thereof. The soft capsule helpful for increasing the bone density is characterized by consisting of the following raw materials in parts by weight: 400-550 parts of linseed oil, 10-30 parts of red deer bone superfine powder, 10-30 parts of an astragalus extract, 10-30 parts of bone collagen, 10-30 parts of an angelica extract, 1-3 parts of vitamin D and 10-30 parts of a drynaria rhizome extract. The soft capsule disclosed by the invention, guided by theories of traditional Chinese medicine and based on modern research achievements of the traditional Chinese medicine, is careful in material selection, strict in composition and rational in combination, and is added with natural components capable of improving osteoporosis, so that the composition can tonify Qi and benefit blood, enhance immunity, relieve fatigue, strengthen tendons and bones, remove pathological wind and promote diuresis, regenerate tissue to heal wound, and integrally improve physical function, and circulations of Qi and blood are smooth, and metabolism is normal. Red deer bone functions as strengthening tendons and bones, and regenerating tissue to heal wound; drynaria rhizome can relieve joint pain, and relieve osteoporosis; vitamin D has a function of resisting rachitis, and can promote calcium absorption; astragalus can promote regeneration of injured nerve; angelica functions as replenishing blood and promoting blood circulation, regulating menstruation and relieving pain, and relaxing bowl; and linseed oil has functions of preventing and treating cancers, coronary heart disease, diabetes, prostatic cancer and other diseases. The composition is remarkable in functions of replenishing blood and benefiting blood, and strengthening tendons and bones.

The invention discloses a polyetheretherketone composite implant as well as a preparation method and application thereof. The composite implant comprises a polyetheretherketone substrate, a degradable polymer coating wrapping the surface of the polyetheretherketone substrate, and a functional substance loaded and / or grafted by the degradable polymer coating; the functional substance comprises a substance with an immune regulation function and / or a substance with an osteogenesis regulation function. The preparation method comprises the following steps: constructing the degradable polymer coating loaded with the functional substance on the surface of the polyetheretherketone substrate; modifying and activating the surface of the degradable polymer coating loaded with the functional substances, and introducing active groups to the surface of the degradable polymer coating loaded with the functional substances; and then the functional substances are grafted through active groups. The polyetheretherketone composite implant is applied to preparation of a medicine for treating bone defects. According to the polyetheretherketone composite implant prepared by the invention, the excellent mechanical property of the substrate polyetheretherketone is maintained, and the immunocompetence and the osteogenic activity of the surface are also increased.

The invention belongs to the medical field and discloses glucosamine bone glue peptide calcium granules. The glucosamine bone glue peptide calcium granules comprises bone collagen peptide, glucosamine, euphausia superb oil, isomaltooligosaccharide, D-ribose, oat essence, algal polysaccharides, dried small shrimp meal, vitamin D3, fish oil and pharmaceutical adjutants. The bone collagen peptide, the glucosamine, the dried small shrimp meal and the euphausia superb oil in the glucosamine bone glue peptide calcium granules can be absorbed by a human body easily, are jointly used for increasing bone density and recovering bone functions, have a synergistic effect and can enhance resistance, maintain beauty and care skin.

The invention provides an adjustable hard bed board with curved surfaces and stereoscopic curves. The adjustable hard bed board comprises a bed side, a hard bed board and 1-2 stereoscopic boards. The upper surface of the hard bed board is provided with the curved surfaces which are identical or similar to physiological curves of human bodies when the human bodies naturally lie on the backs, and the hard bed board is of an integrally formed structure; the stereoscopic boards comprise legs and boards, the boards are mounted on the legs, planes are arranged on the upper surfaces of the boards, the heights of the planes on the boards are flush with upper planes at two ends of the hard bed board, fast mounting structures are arranged on a side of each board, and fast mounting connectors which correspond to the fast mounting structures are arranged at the front end and the rear end of the hard bed board. The adjustable hard bed board with the curved surfaces and the stereoscopic curves has the advantages that the adjustable hard bed board is scientific in design and conforms to ergonomics, and bone functions can be supported and recovered by the aid of hard board beds.

The invention discloses a medicine for treating hyperosteogeny of the lumbar spine and a preparation method thereof. , red peony root, rehmannia glutinosa, cassia twig, black snake, frankincense, myrrh, salvia miltiorrhiza, sumac, Caulis Spatholobus, red peony root, amomum, lovage, and tribulus terrestris are prepared according to a certain weight ratio. The medicine of the present invention has Dispelling wind and dredging collaterals, dispelling phlegm and dispelling addiction, promoting blood circulation and promoting menstrual flow, removing blood stasis and relieving pain, tonifying liver and kidney, and strengthening bones and muscles. It is used for the treatment of lumbar hyperosteogeny with quick effect, good curative effect, and no recurrence.

The invention relates to the application of CDC20 in the osteogenic differentiation process of mesenchymal stem cells. It was found that CDC20 can positively regulate the osteogenic function of mesenchymal stem cells, which provided the basis for the application of CDC20 in promoting the osteogenic differentiation of mesenchymal stem cells, and identified its effect on NF‑κB active subunit p65 through proteasome Mechanism of action for pathway degradation. It provides a new theoretical and experimental basis for the targeted use of small molecular compounds to inhibit the activity of target proteins in the molecular therapy of bone regeneration.

The invention discloses AB glue for intraoperative bleeding arresting of a bone surgery. Glue A is chitosan-starch paste containing a water-soluble calcium salt, and glue B is paste containing sodiumbeta-glycerophosphate, water-soluble phosphate and hydroxymethyl cellulose. After substances of the glue A and the glue B are mixed, an in-situ reaction can occur to form gel, which can be randomly filled in a bone defect and shape in 20 minutes after implanting, and thus, the AB glue has bleeding arresting and osteogenesis functions and can be applied to the intraoperative bleeding arresting of the bone surgery instead of bone wax. Compared with the traditional bone wax, the AB glue has the advantages that besides reserving the characteristics of random filling and bleeding arresting, the ABglue further has the advantages of good biocompatibility, degradability and osteogenesis promoting; and meanwhile, due to design of tubes A and B, the long-term stability of the material is guaranteed.

The invention discloses a method for covalently grafting biomolecules on the surface of metal materials. First, a diamond-like carbon film is constructed on the surface of the metal implant material, and then the film is activated, and then the material is immersed in a solution containing biomolecules that promote osteogenesis, so that biomolecules can be covalently grafted on the surface of the metal implant material. On the other hand, the technology of the present invention is easy to operate, simple in process, mild in reaction conditions, can be carried out at room temperature, high in efficiency, low in cost, good in repeatability, simple in subsequent cleaning procedures, and does not use silane coupling agents and crosslinking agents , there is no risk of reagent residue, which is conducive to industrial production. Therefore, the product prepared according to the method of the present invention has a high application prospect in the field of medical implant materials.

The invention discloses an AB glue for hemostasis in orthopedic surgery, wherein glue A is chitosan-starch paste containing water-soluble calcium salt, and glue B is made of sodium β-glycerophosphate, water-soluble phosphate and hydroxymethyl cellulose Plain paste. When the substances of AB glue are mixed, they can react in situ to form a colloid that can fill bone defects arbitrarily and form within 20 minutes after implantation. It has the function of hemostasis and osteogenesis, and can replace bone wax for hemostasis in orthopedic surgery. Compared with traditional bone wax, in addition to retaining the characteristics of arbitrary filling and hemostasis, this material also has the advantages of good biocompatibility, degradability, and bone formation. At the same time, the design of the AB tube ensures the long-term stability of the material.

The invention belongs to the medical field and discloses glucosamine bone glue peptide calcium granules. The glucosamine bone glue peptide calcium granules comprises bone collagen peptide, glucosamine, euphausia superb oil, isomaltooligosaccharide, D-ribose, oat essence, algal polysaccharides, dried small shrimp meal, vitamin D3, fish oil and pharmaceutical adjutants. The bone collagen peptide, the glucosamine, the dried small shrimp meal and the euphausia superb oil in the glucosamine bone glue peptide calcium granules can be absorbed by a human body easily, are jointly used for increasing bone density and recovering bone functions, have a synergistic effect and can enhance resistance, maintain beauty and care skin.

The invention relates to a cooking stove, in particular to a special stove for making bone buns with the function of baking. A kind of bone steamed bun baking furnace, which is composed of a furnace body, a furnace bottom, a damper, a fire grate, a furnace door, a furnace top, a baking furnace groove and sand pellets. Compared with the existing technology, because the furnace does not directly heat the buns, but uses sand pellets as an indirect heating method, the outer shell of the buns is slowly baked with hot air, and the inside of the buns is cooked by hot sand pellets, so it is slowly baked and hardened. Afterwards, the shape of the bun is like a big white bone, not black, not burnt, not yellow, and it tastes: the outer shell is hard and crisp, the inner gluten is glutinous, and the taste of wheat is strong.

The invention discloses a 3D printed bone tissue engineering scaffold with functions of sustained release and osteogenesis promotion and a preparation method thereof, belonging to the technical field of biomedical materials. The scaffold is formed by in-situ cross-linking of porous calcium phosphate material and sodium alginate, and simultaneously loads drug icariin. The bone tissue engineering scaffold prepared by the present invention has good biocompatibility and bioactivity. At the same time, by adding icariin drug to the printing ink, the osteogenic performance of the scaffold is further enhanced, and finally regulated by 3D printing and post-processing The pore structure of the scaffold, the cross-linking degree of the scaffold can be adjusted by changing the concentration of the calcium chloride cross-linking agent and the cross-linking time, and then the degradation rate of the material in vivo can be adjusted. The sustained drug release effect of the stent is realized by changing the drug concentration to regulate the drug loading of the stent. The stent material of the present invention can be used as artificial bone and bone tissue engineering reconstruction and repair, and has broad clinical application prospects.