2 results about "Bone function" patented technology

This invention belongs to the technical field of medical materials and discloses a core-shell microneedle patch with anti-inflammatory and cartilage-protective functions, its preparation method, and its application. Method: 1) Prepare psoralen-loaded nanoparticles Mi@PSO; 2) Prepare a shell solution by mixing methacryloyl hyaluronic acid, HPA, and a photoinitiator; prepare a core solution by mixing HA and Mi@PSO; add the shell solution to the needle cavity of a microneedle mold and perform ultraviolet cross-linking to form the shell layer; add the core solution to the interior of the shell layer to form the core layer; add a hyaluronic acid solution to the mold, dry to form a backing layer, and demold to obtain a core-shell microneedle patch with anti-inflammatory and cartilage-protective functions. The microneedle patch of this invention has a regular needle morphology, a clear core-shell layered structure, good mechanical properties and skin puncture ability, and stable continuous release behavior; achieving inflammation regulation and cartilage protection. The microneedle patch of this invention is used to prepare products for the local treatment of rheumatoid arthritis.

The application discloses a bone-strengthening milk protein extract and a preparation method and application thereof, and belongs to the technical field of deep processing of cow milk. The bone-strengthening milk protein extract contains a bone-strengthening active peptide FYPELFR, and the preparation method specifically comprises the following steps: (1) pasteurization; (2) casein separation; (3) pepsin hydrolysis; (4) trypsin hydrolysis; (5) purification and desalination; and (6) concentration and drying. The bone-strengthening active peptide and the bone-strengthening milk protein extract containing the same can be combined with integrin alpha v beta 1 through hydrophobic interaction and hydrogen bonding, can promote the proliferation and differentiation of osteoblasts by activating specific signal pathways, can promote the proliferation of osteoblasts, can be used for the development of bone-strengthening functional food or medicine, and has important significance for the deep processing of cow milk.