13 results about "Bone function" patented technology

The invention discloses a bone-strengthening lactoprotein extract as well as a preparation method and application thereof, and belongs to the technical field of deep processing of cow milk. The bone-strengthening milk protein extract contains bone-strengthening active peptide FYPELFR. The preparation method specifically comprises the following steps: (1) pasteurization; (2) separating casein; (3) pepsin hydrolysis; (4) trypsin hydrolysis; (5) purifying and desalting; and (6) concentrating and drying. The bone-strengthening active peptide and the bone-strengthening lactoprotein extract containing the bone-strengthening active peptide can be combined with integrin alpha v beta 1 through hydrophobic interaction and hydrogen bonds, proliferation and differentiation of osteoblasts are promoted by activating a specific signal channel, proliferation of the osteoblasts is promoted, and the bone-strengthening active peptide and the bone-strengthening lactoprotein extract can be used for development of bone-strengthening functional food or drugs and have important significance on deep processing of cow milk.

The invention discloses a muscle-bone dysfunction early warning and intervention method based on bioelectricity signals, and relates to the technical field of muscle-bone signal data processing.The method comprises the steps that original electromyographic signal data are obtained, and a multi-scale entropy curve reflecting neuromuscular coordination and a tremor precursor frequency band energy curve reflecting stability are calculated respectively; a target monitoring point is extracted based on hyperbola features, an instability risk coefficient is calculated, and dominant instability risk judgment and primary intervention are achieved; and further through multi-scale decomposition and instantaneous phase synchronization analysis, in combination with calculation of trajectory deviation and data dispersion, precise identification and secondary intervention of the recessive instability risk are realized. Through multi-level coupling analysis of coordination and stability, a full-dimension risk assessment system from dominance to recessiveness is established, differentiated intervention instructions are generated, and finally the problems of monitoring blind areas and hysteresis in early warning of a traditional method are effectively solved.

This invention belongs to the technical field of medical materials and discloses a core-shell microneedle patch with anti-inflammatory and cartilage-protective functions, its preparation method, and its application. Method: 1) Prepare psoralen-loaded nanoparticles Mi@PSO; 2) Prepare a shell solution by mixing methacryloyl hyaluronic acid, HPA, and a photoinitiator; prepare a core solution by mixing HA and Mi@PSO; add the shell solution to the needle cavity of a microneedle mold and perform ultraviolet cross-linking to form the shell layer; add the core solution to the interior of the shell layer to form the core layer; add a hyaluronic acid solution to the mold, dry to form a backing layer, and demold to obtain a core-shell microneedle patch with anti-inflammatory and cartilage-protective functions. The microneedle patch of this invention has a regular needle morphology, a clear core-shell layered structure, good mechanical properties and skin puncture ability, and stable continuous release behavior; achieving inflammation regulation and cartilage protection. The microneedle patch of this invention is used to prepare products for the local treatment of rheumatoid arthritis.

The present invention relates to a rotational osteotomy shortening device, which belongs to the field of medical devices and comprises a rotational osteotomy plate, a bone bending structure fixedly provided on the upper end of the rotational osteotomy plate, an osteotomy length indicator plate fixedly provided on the right side of the rotational osteotomy plate, a sliding protective shell sleeved on the outer side of the osteotomy length indicator plate, and a rotational osteotomy guide groove provided on the bottom of the sliding protective shell. The present invention proposes a rotational osteotomy shortening device that has the functions of rotational bone shrinking, bone bending and rotational osteotomy, thereby realizing cutting of different bone segments at different angles according to target posture requirements, thereby ensuring that the subsequent connection after amputation can restore the normal posture of the bone, realizing that the two bone segments after amputation can restore the initial force line by selecting a rotation or bone bending method, realizing deflection of the movable bone segment, thereby realizing bending of the movable bone segment and the fixed bone segment, so that the two shortened bone segments can still maintain a normal posture, thereby ensuring that the bone after osteotomy and shortening can return to a normal posture and be used normally according to the initial force line, greatly improving the success rate of the operation and the safety of postoperative recovery.

The invention relates to the technical field of medical treatment. The direction-adjustable bone grafting set comprises a bone grafting sleeve, the front end of the bone grafting sleeve is in flexible connection with a needle cylinder through a shaping connector, and the upper portion of the middle section of the bone grafting sleeve is provided with a feeding hopper used for implanting an implant material; a bone grafting channel is formed between the feeding hopper and the needle cylinder; the bone grafting rod is arranged at the rear end of the bone grafting sleeve and is used for pushing an implant material to move in the bone grafting channel. According to the bone grafting device, the bone grafting direction and the bone grafting depth can be conveniently and flexibly adjusted, the bone grafting accuracy can be improved, it is ensured that an implanted material is perfectly matched with a defect area, and the bone function is better recovered.

The utility model relates to a chicken claw bone crushing and removing all-in-one machine with bone crushing and removing functions, which comprises a multi-stage roller extrusion device, a roller screen device and a frame, support legs are fixedly mounted at the bottom of the frame, a power supply box is fixedly mounted on the back of the multi-stage roller extrusion device, and the roller screen device is connected with the power supply box. A funnel-shaped feeding port is formed in the top of the multi-stage roller extrusion device, and a discharging plate is arranged on the front face of the multi-stage roller extrusion device. According to the chicken claw bone-crushing and bone-removing all-in-one machine with the bone-crushing and bone-removing functions, firstly, the machine is placed on the stable ground, then after electric control equipment is started, chicken claws subjected to bone removal are placed into a funnel-shaped feeding opening, then clamping claws are extruded through an extrusion roller, and the chicken claws fall onto a discharging plate after being extruded for four times and finally fall into a rolling screen device; the bones and the clamping jaws are separated in the roller screen device, bone residues can enter the recycling box, and chicken feet fall into the material receiving box through the funnel-shaped discharging opening after being blocked by the baffle.

The application discloses a kind of based on metal continuous porous network structure's fusion type tantalum-silver composite double-layer functional coating material and its preparation method, its preparation method is: 1) using specific electrolyte formula, using ultra-high voltage anodic oxidation process on the surface of cleaned titanium / titanium alloy controllable construction first continuous porous metal network structure;2) vacuum heating cleaning removes titanium / titanium alloy surface impurities, carries out physical vapor deposition (PVD) on its surface, and fuses into secondary tantalum coating structure in hole;3) replace silver target material, vacuum heating cleaning twice, carry out double PVD and fuse into tertiary silver coating structure in network hole, so that it completely covers porous metal network structure;4) the sample after processing is carried out vacuum high-temperature pressure-keeping heat treatment;5) after multiple cleaning, packaging and irradiation sterilization, continuous porous network structure's fusion type tantalum-silver composite double-layer functional coating material is obtained.The application has long-acting antibacterial and promotes bone function, and can be used in orthopedics, dental field.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for improving osteoarthropathy and a preparation method and application thereof. The invention discloses a traditional Chinese medicine with the effects of tonifying liver and kidney, expelling wind-damp, dredging channels and collaterals and strengthening muscles and bones. The traditional Chinese medicine is mainly prepared from the following raw medicinal materials: radix puerariae, astragalus membranaceus, rhizoma drynariae, ginseng, Chinese yam, bighead atractylodes rhizome, pawpaw, eucommia ulmoides, angelica sinensis, ligusticum wallichii, notopterygium root, radix angelicae pubescentis, prepared rehmannia root, cistanche, zaocys dhumnade and radix achyranthis bidentatae. The channel tropism of the medicines in the formula is basically and directly related to the liver and the kidney, and the medicines are combined to achieve a good function of strengthening tendons and bones. Clinical research proves that the compound has a remarkable effect on dysfunction caused by osteoarthrosis, stasis-accumulating swelling and pain or muscle and bone injury and the like.

The invention discloses a method for in-situ preparation of a metal organic network modified titanium dioxide nanotube composite coating on the surface of a titanium implant, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: firstly, forming an ordered titanium dioxide nanotube array on the surface of a titanium implant through anodic oxidation, and anchoring eight-arm polyethylene glycol of which the tail end is modified with alendronate on the surfaces of nanotubes by utilizing the strong affinity of alendronate to titanium dioxide; then, epigallocatechin gallate (EGCG), Zn < 2 + > and Ca < 2 + > are introduced, and the multifunctional metal organic network coating is formed in situ through coordination self-assembly. The obtained composite coating can synergistically release active components, has the functions of resisting oxidation, promoting angiogenesis, promoting osteogenesis and inhibiting osteoclast, and remarkably improves the osseointegration capacity of a titanium implant in an osteoporosis microenvironment. The coating provided by the invention is stable in structure and high in biological activity, is suitable for osteoporotic fracture internal fixation instruments, and has a good clinical application prospect.

The invention relates to diagnostic software for providing data for the manufacture of a jaw splint for a person, wherein an actual dental space condition and / or tooth position (1) and an actual jaw function (2) are recorded, wherein - an actual body posture (3) is recorded, and - an actual foot pressure (4) is recorded, and - the actual tooth space condition and / or tooth position (1) is compared with a target tooth space condition and / or tooth position (11) in order to determine an initial deviation (a) between the actual tooth space condition (1) and the target tooth space condition (11), - the actual jaw function (2) is compared with a target jaw function (12) in order to determine a second deviation (b) between the actual jaw function (2) and the target jaw function (12), - the actual body posture (3) is compared with a target body posture (13) in order to determine a third deviation (c) between the actual body posture (3) and the target body posture (13), - the actual floor pressure (4) is compared with a target floor pressure (14) to determine a fourth deviation (d) between the actual floor pressure (4) and the target floor pressure (14), wherein - the collected data will be used to manufacture the jaw splint, suitable for reducing the deviations (a, b, c, d).

The invention belongs to the technical field of bone tissue engineering and regenerative medicine, and particularly discloses a piezoelectric-photo-thermal dual-mode composite stent for articular cartilage repair and a preparation method of the piezoelectric-photo-thermal dual-mode composite stent. The preparation method comprises the three steps of MXene preparation, electrostatic spinning and paper folding structure construction, poly-L-lactic acid and MXene nanosheets are compounded to prepare a fiber membrane, and then the fiber membrane is subjected to hot pressing through a corrugated mold to form the three-dimensional stent with the periodic creased structure. The scaffold has piezoelectric property and photo-thermal property at the same time, promotes cartilage differentiation through the piezoelectric effect, inhibits subchondral bone angiogenesis through the photo-thermal effect, maintains a low-oxygen microenvironment, realizes integral repair of cartilage-subchondral bone functional units, can be used for treatment of cartilage defects, osteochondral defects and osteoarthritis, and has a wide application prospect. The problem that the cartilage steady state is damaged due to the fact that a traditional piezoelectric material promotes bone vascularization is solved.

This invention discloses an encapsulated nano-curcumin composition for metabolic regulation and bone health, and its preparation method, belonging to the field of functional food and nano-preparation technology. The composition comprises, by mass percentage: 0.12%-0.40% liposome nano-curcumin (60%-80% pure curcumin content, average particle size 60-80 nm), 2.0%-8.0% whole bone and joint base powder, 1.0%-5.0% phospholipids, 0.2%-1.0% cholesterol, 0.5%-8.0% stabilizer, and the balance being purified water, with an ionic strength ≤50 mM and pH 5.5-6.5. The preparation method includes organic phase preparation, active ingredient dispersion, aqueous phase preparation, phase dispersion molding, high-pressure homogenization, grading and granulation, compounding and blending, and aseptic filling. This invention solves the problems of low curcumin absorption rate and instability of liposomes combined with bone nutrients by precisely controlling the liposome particle size window and system ionic strength. It achieves synergistic effects of metabolic regulation, fat reduction assistance and bone care. The product has excellent stability, is suitable for industrial production, and can be used to prepare health food with fat reduction function without bone loss.