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35 results about "Disease spleen" patented technology

Diseases of the spleen may have various causes. Sometimes it is inherited, otherwise it can result from another disease such as severe malaria, tuberculosis, a certain kind of blood disorder or rheumatoid arthritis.

Holstein cow spleen-derived antibacterial peptide as well as preparation method and application thereof

The invention discloses an antibacterial peptide which is obtained by being separated from a Holstein cow spleen and has antibacterial activity, namely a Holstein cow spleen-derived antibacterial peptide, wherein an amino acid sequence of the Holstein cow spleen-derived antibacterial peptide is shown in SEQ ID NO.1. The antibacterial peptide disclosed by the invention is separated from a cow spleen, and the spleen is one of immune organs of an animal and participates blood storage and immunologic processes, so that the antibacterial peptide is extremely low in hemolysis ratio; meanwhile, the antibacterial peptide has some safe biological characteristics without toxic or side effect such as broad antibacterial spectrum, speediness in sterilization, high selectivity, no drug resistance, no teratogenic effect and difficulty in formation of accumulative intoxication, is broad in antibacterial spectrum, has efficient antibacterial effect on Gram negative bacteria, Gram positive bacteria and fungi, can be used for preparing medicines used for treating the Gram negative bacterial, Gram positive bacterial or / and fungal infection and also can be used as a feed additive or a food additive.
Owner:HENAN INST OF SCI & TECH

Duck reovirus causing duck spleen necrosis as well as inactivated vaccine and application thereof

The invention discloses a duck reovirus causing duck spleen necrosis as well as inactivated vaccine and an application thereof. The duck reovirus is preserved in China Center for Type Culture Collection on July 18, 2018, with preservation number of CCTCC NO: V201843. The duck reovirus provided by the invention shows excellent immunogenicity on duck reovirus taking the spleen necrosis as a major symptom. The inactivated vaccine, which is prepared by the duck reovirus strain, is good in safety; and a 100% protecting rate can be achieved, so that newly separated variant strains can be completelyprotected.
Owner:SHANDONG AGRICULTURAL UNIVERSITY

Use of calycosin-7-glucoside in preparation of drugs for treating asthma

InactiveCN106551945AHigh airwayHigh airway hyperresponsivenessOrganic active ingredientsAntipyreticAllergic asthmaIn vivo
The invention belongs to the pharmaceutical field, relates to a novel medicinal use of calycosin-7-glucoside and especially relates to a use of calycosin-7-glucoside in preparation of drugs for treating asthma and especially for treating allergic asthma. The results of an in-vivo animal experiment and an in-vitro CD4+T cell culture experiment show that calycosin-7-glucoside has effects on an ovalbumin-induced mouse asthma model and CD4+T cells isolated from spleen, and can significantly reduce airway hyperresponsiveness of asthmatic mice, inhibit airway inflammation, reduce the number of inflammatory cells in an alveolar lavage fluid, inhibit chemokine secretion, promote Th1 cell differentiation, inhibit IL-17A, promote IFN-gamma and IL-10 secretion and inhibit NF-kappa B activation. The calycosin-7-glucoside can be used as a single ingredient for preparation of drugs for treating asthma or allergic asthma.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV

Application of PDE9A inhibitor in preparation of products for increasing Treg (Regulatory cell) content, drugs for preventing and treating inflammatory bowel diseases as well as health care products

The invention relates to application of a PDE9A inhibitor in preparation of products for increasing Treg (Regulatory cell) content, drugs for preventing and treating inflammatory bowel diseases as well as health care products, and relates to the field of medicines. The PDE9A inhibitor can improve mucus secretion of a mucous membrane in the intestinal tract with inflammatory bowel diseases, reducesecretion of TNF- alpha, IL-6, IL-17 and IL-12 / IL-23 pro-inflammatory factors, inhibit DC cell differentiation and migration, increase the proportion of Foxp3+Treg cells and promote the movement of CD4+CD25+Treg cells from the spleen and mesenteric lymph nodes into the colon, thereby inhibiting the inflammatory reaction of the intestinal tract and controlling occurrence and development of the diseases. When applied to drugs for preventing and treating inflammatory bowel diseases, the PDE9A inhibitor can effectively prevent, alleviate and treat the inflammatory bowel diseases; and furthermore,the health care products taking the PDE9A inhibitor as an active component can condition the intestinal tracts of patients suffering from inflammatory bowel diseases so as to control occurrence and development of the inflammatory bowel diseases.
Owner:ZHEJIANG UNIV

Chinese medicine formula for treating ascitesduetocirrhosis

InactiveCN102406909AAdjustment ratioSignificant retractionNervous disorderDigestive systemSide effectMedicine
The invention discloses a Chinese medicine formula for treating ascitesduetocirrhosis, which relates to the field of Chinese medicine preparations. The Chinese medicine formula is characterized by comprising costus root, cardamom, myrrh, dried orange peel, white paeony root, immature bitter orange, black cardamom, tuckahoe, areca peel, officinal magnolia bark, root of three-nerved spicebush, areca nut, ginseng, dandelion, astragalus and agilawood. The formula has the advantages of effectively softening liver, contracting spleen, regulating protein ratio, allowing swelling liver and spleen to contract obviously, obviously improving hypersplenism, relieving anemia and bleeding, and restoring the normal size of the spleen basically. The medicine disclosed by the invention is pure Chinese medicine preparation which is free from toxic and side effects and has an obvious effect.
Owner:徐天英

Compound lactobacillus plantarum preparation with blood sugar reducing function and application of preparation

The invention discloses a compound lactobacillus plantarum preparation with a blood sugar reducing function and an application of the preparation. The compound bacterium consists of lactobacillus plantarum SS18-5 with the collection number of CGMCC No.14917 and lactobacillus plantarum SS18-37 with the collection number of CGMCC No.14918. In the compound bacterium, the CFU ratio of the lactobacillus plantarum SS18-5 to lactobacillus plantarum SS18-37 is 1:(0.01-100). The invention also discloses the application of the compound bacterium in preparation of a product. The product is used for treating and / or preventing diabetes. The preparation has the good blood sugar reducing effect on diabetes, can significantly improve insulin resistance, has protection effects on heart, liver, kidney, spleen and pancreas and has broad market application prospects.
Owner:FULLARTON BIOENG TECH BEIJING CO LTD

Black garlic extract and application thereof in preventing and curing breast cancer

The invention belongs to the technical field of food, and discloses a black garlic extract and application thereof in preventing and curing breast cancer. It is proved by the cell test that the black garlic extract inhibits growth of breast cancer MD231 cells and T47D cells in a concentration-dependent and time-dependent manner, so that the adhesiveness among cancer cells is enhanced, and the vigor of the cancer cells is reduced; besides, it is proved by the animal test that the black garlic extract can inhibit growth of nude mouse MCF-7 transplanted tumor remarkably, the gross tumor volume is reduced, the thymus index and the spleen index are increased, tumor immunosuppression is avoided, and the black garlic extract has the immunological enhancement effect. Therefore, the black garlic extract can be used for preventing and curing breast cancer, is rich in source and pure-natural, and has important development and application prospects.
Owner:广东益生康生物科技有限公司

Tilapia feed additive capable of reducing proinflammatory response and enhancing immune response and preparation method and application thereof

The invention provides a tilapia feed additive for reducing proinflammatory response and enhancing immune response and a preparation method and an application thereof, and belongs to the technical field of aquaculture. The tilapia feed additive for reducing proinflammatory response and enhancing immune response comprises the following components in parts by weight: 25-35 parts of manyprickle acanthopanax stems, 15-25 parts of loquat leaves, 15-25 parts of tripterygium wilfordii, 10-20 parts of hawthorn fruits and 10-20 parts of mulberry leaves. The invention also provides a tilapia feed containing the tilapia feed additive, and an application of the tilapia feed additive or the tilapia feed in tilapia breeding. The application can effectively reduce the proinflammatory response of the headkidney tissue and the spleen tissue of the tilapia, and enhance the immune response capability of the tilapia, thereby improving the capability of the tilapia against streptococcal infection.
Owner:FRESHWATER FISHERIES RES CENT OF CHINESE ACAD OF FISHERY SCI

Composite fermented traditional Chinese medicine composition for preventing and treating chicken infectious bursal disease

The invention discloses a composite fermented traditional Chinese medicine composition for preventing and treating a chicken infectious bursal disease. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 25-40 parts of radix isatidis, 25-40 parts of gynostemma pentaphylla, 30-50 parts of dandelion, 10-30 parts of honeysuckle, 50-70 parts of mugwort leaf, 30-50 parts of herba andrographitis, 1-8 parts of toad-cortex, 2-8 parts of borneol, 5-18 parts of liquorice, and 5-20 parts of munjeet. The traditional Chinese medicine composition is prepared from the following steps: smashing the components in ultrasound; adding fermented culture medium and compound bacteria liquid; conducting enclosed anerobic fermentation at 36-37 DEG C for 12-14 h; adding a stabilizer in the fermented product; conducting vacuum low-temperature drying. The traditional Chinese medicine composition prepared from microbe fermentation acts with the microbe, is converted into components easy to be ingested and utilized by bodies, accelerates treating speed, improves curative effect, and micro-ecology environment of bodies, improves animal food return rate and performance trait, can effectively relieve, eliminate or remarkably relieve symptoms of bleeding, death and the like caused by chicken infectious bursal disease, reduces pathological damage of bursa of Fabricius, milt and the like, relieves potential safety hazards caused by chemical drugs, and improves safety of pharmacy.
Owner:河南天纳图生物科技有限公司

Application of panaxadiol saponin in preparing medicines combined with glucocorticoid receptor

The invention relates to application of panaxadiol saponin (PDS) in preparing medicines combined with a glucocorticoid receptor, and belongs to the field of medicines. The panaxadiol saponin is applied to preparing the medicines combined with the glucocorticoid receptor, and the panaxadiol saponin and cis-platinum are jointly applied to resisting tumors; and in the study that the PDS and the cis-platinum are combined to resist prostatic cancer transplanting tumors, the PDS has antiallergic and attenuation effects like Dexa, but the PDS group has the survival time, spleen index, fur brightness degree and the like superior to those of the Dexa group. Mice in a Dexa and cis-platinum combined administration group all die before the 13th days in the course of treatment particularly. Therefore, the PDS has the same molecular mechanism as the Dexa, and has important significance for developing new medicines in which the PDS replaces the Dexa.
Owner:JILIN UNIV

Method of detecting specific killing effects of chicken spleen CD8<+>T cells based on flow cytometry

The invention relates to a method of detecting specific killing effects of chicken spleen CD8<+>T cells based on flow cytometry. The method comprises a first step of bacterial culture in which the bacteria are salmonella pullorum S06004 and S06004deltaspiC, a second step of chick immunization and sampling, a third step of target cell-macrophage preparation, a fourth step of effector cell-chicken spleen CD8<+>T cell preparation which comprises a substep of preparation of a chicken spleen lymphocyte suspension and a substep of magnetic bead sorting of a chicken spleen CD8<+>T cell and a fifth step of specifically killing macrophage by CTL. Compared with the prior art, the method disclosed in the invention has the following beneficial effects that the macrophage (target cell) obtained by adherence has high purity, the sorting effects for chicken spleen CD8<+>T cells are obvious, and the separation time is short; with the salmonella host cell- macrophages as the target cell, the salmonellaremoving ability by the host can be reflected more accurately; and the flow cytometry is used for chicken spleen CD8<+>T cell specific killing effects and can detect the CTL effects of the chicken spleen CD8<+>T cell in a single cell level.
Owner:YANGZHOU UNIV

Goat F17 escherichia coli infection resisting gene screening method

The invention discloses a goat F17 escherichia coli infection resisting gene screening method which includes the steps: F17 escherichia coli infection diseased lamb and disease-resistant lamb screening and spleen and intestinal canal content sample acquisition; F17 escherichia coli infection diseased lamb and disease-resistant lamb spleen sample high-throughput sequencing; F17 escherichia coli infection diseased lamb and disease-resistant lamb spleen transcriptomics comparative analysis; F17 escherichia coli infection resisting gene (circRNA) screening and identifying. The goat F17 escherichiacoli infection resisting gene screening method is used for screening F17 escherichia coli infection resisting genes (circRNA) from disease-resistant lamb spleens in a targeted manner, is high in accuracy and pertinence and saves time.
Owner:YANGZHOU UNIV

High-efficiency producing method for purified porcine leukocyte interferon by employing porcine spleen

The invention discloses a high-efficiency producing method for purified porcine leukocyte interferon by employing a porcine spleen and belongs to the technical field of biological pharmacy. The method includes steps of collecting fresh porcine spleens and cryopreserving the porcine spleens below -10 DEG C, melting, crushing, washing and digesting the frozen porcine spleens to separate leukocytes during usage, adding a Newcastle disease virus, carrying out an inductive fermentation culturing process in a fermentation tank, carrying out a separation process and a virus inactivating process to obtain a crude porcine leukocyte interferon, carrying out an ion-exchange process and a high-pressure reverse direction chromatography purification process to obtain a purified porcine leukocyte interferon original fluid, carrying out a vacuum freeze drying carrying out a vacuum freeze drying preparation process to obtain a purified porcine leukocytes interferon powder injection. The purified porcine leukocytes interferon belongs to a pure natural biological product, has effects of antivirus activity and increasing body immunity, and can be used for preventing and curing a plurality of viral infectious diseases such as swine fever, porcine reproductive and respiratory syndrome and diarrhea, etc. The purified porcine leukocytes interferon is produced with a raw material being the porcine spleens instead of porcine blood. The method is simple in technology, good in product quality and low in cost, and develops a new approach for producing the porcine leukocyte interferon.
Owner:北京紫辰医药生物技术研究所

Medicinal eye patch for treating blurred vision and preparation method of medicinal eye patch

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to a medicinal eye patch for treating blurred vision and a preparation method of the medicinal eye patch. The medicinal eye patch consists of an eye patch body with cavities and a traditional Chinese medicinal component putted in the cavities of the eye patch body. The traditional Chinese medicinal component is prepared from the following raw materials in parts by weight: 30 to 50 parts of cape jasmine fruit, 16 to 30 parts of radix et rhizoma rhei, 16 to 30 parts of radix curcumae, 30 to 50parts of rhizoma coptidis, 16 to 30 parts of radix scutellariae, 18 to 35 parts of airpotato yam rhizome, 18 to 35 parts of oriental stephania root, 15 to 30 parts of myrrh, 25 to 40 parts of concha haliotidis, 25 to 40 parts of semen cassiae and 30 to 50 parts of mulberry leaves. The medicinal eye patch has the advantages of reasonable formula, simple pharmacy process, low cost, high penetrationcapability, quick absorption, bacteria resistance, inflammation elimination and obvious effects of promoting circulation and removing stasis. The medicinal eye patch can promote regeneration of bloodvessels in crystals and enables patients with the blurred vision to be cured; in addition, a product is an external pure traditional Chinese medicinal product and is convenient to use, pollution-freeand convenient to carry; besides, a medicine can directly act eye parts without metabolism of spleen and liver of a human body and quickly takes effect without side effects.
Owner:吴晓旭

Feed for enhancing immunity of carps

The invention provides a feed for enhancing the immunity of carps. The feed consists of the following components in percentage by weight: 85-95% of a basal feed, 4-15% of a traditional Chinese medicine additive and 0-1% of mango leaf extractum. The feed disclosed by the invention is a natural, efficient and stable traditional Chinese medicine composition, can have the effect of effectively enhancing the activity of lysozyme in hepatopancreas and the spleens of the carps, effectively strengthens the antibacterial defense functions of organisms, enhances the immunity of the carps, besides, reduces the condition of slow growth of the carps caused by stress response, and promotes the carps to grow.
Owner:TIANJIN JINHAIMA AQUACULTURE

Sophora flavescens polysaccharide as well as preparation method thereof and use thereof in liver protection and immune regulation

The invention relates to sophora flavescens polysaccharide as well as a preparation method thereof and use thereof in liver protection and immune regulation. The sophora flavescens polysaccharide is extracted from sophora flavescens root in a way of water extraction. A polysaccharide component in the sophora flavescens polysaccharide is obtained by means of further separation. Experiments prove that the sophora flavescens polysaccharide and the polysaccharide component thereof can promote mouse spleen cell proliferation and cytokine secretion, promote human hepatocyte proliferation and reducethe damage of chemical agents to cells, inhibit the expression of hepatitis B surface antigen and core antigen, inhibit the proliferation of hepatocarcinoma cells and inhibit the damage, caused by ConA, to the liver and kidney of a mouse, thus being used for preparing immunomodulatory, anti-tumor and anti-hepatic injury drugs.
Owner:SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M +2

Medicine composition for improving immune function of human body as well as preparation method and application

The invention discloses medicine composition for improving the immune function of a human body and a preparation method of the medicine composition. The medicine composition is prepared from components of raw materials in parts by weight as follows: 8-80 parts of ficus hirta, 5-60 parts of radix angelicae sinensis and 1-30 parts of ganoderma lucidum. Experiments indicate that the medicine composition has the function of improving the immune function of the human body, the influence of the medicine composition on carbon particle clearance indexes, phagocytic indexes, thymus indexes, spleen indexes and other indexes of immunosuppressed mice is higher than that in two-two compatibility group, and results indicate that the components have a synergistic function. Besides, the medicine composition can remarkably reduce the TC and TG level in serum of the mice and has a blood fat reduction function.
Owner:北京京师脑力科技有限公司

Application of dracocephalum heterophyllum benth in medicines for prevention and treatment of joint damage/rheumatoid arthritis.

The invention provides application of dracocephalum heterophyllum benth in medicines for prevention and treatment of joint damage / rheumatoid arthritis. The dracocephalum heterophyllum benth dracocephalum heterophyllum benth is used as a medicine for prevention and treatment of rheumatoid arthritis. The dracocephalum heterophyllum benth significantly down-regulates the levels of proinflammatory cytokines TNF-alpha, IL-6 and IL-1beta in important inflammatory sites such as spleen and paw by inhibiting joint damage and swelling; at the same time, the dracocephalum heterophyllum benth lowers the serum levels of cytokines TNF-Alpha or / and IL-6 to relieve arthritis / joint injury in mice and prevent and treat rheumatoid arthritis. The dracocephalum heterophyllum benth has significant therapeuticeffects on joint damage / rheumatoid arthritis caused by autoimmune immune response of the body and has small side effects and remarkable therapeutic effects, the material distribution is wide, resources are abundant, and preparation in batches is easy.
Owner:江西华普康明生物科技有限公司

Biological detection method used for quality evaluation on and quality control over heat-clearing and detoxifying traditional Chinese medicines

ActiveCN106591414AGuarantee high quality and effectivenessObjective Quantitative Evaluation MethodMicrobiological testing/measurementMaterial analysisMedicineQuality control
The invention provides a biological detection method used for quality evaluation on and quality control over heat-clearing and detoxifying traditional Chinese medicines. The biological detection method comprises the steps of firstly adopting a method of anti-rabbit erythrocytea condensation outside the body to represent anti influenza virus activity of heat-clearing and detoxifying traditional Chinese medicines, then adopting a method of anti-mouse spleen swelling method inside the body to represent immune anti-inflammatory activity of heat-clearing and detoxifying traditional Chinese medicines, comparatively completely representing activity of anti-pathogenic microorganisms and anti-inflammatory-immune regulation of heat-clearing and detoxifying medicinal materials through the combination of identification experiments inside and outside the body, and identifying the quality of the medicinal materials through a biological evaluation method. The biological detection method used for the quality evaluation on and the quality control over the heat-clearing and detoxifying traditional Chinese medicines provides a more objective quantitative evaluation method for the clinical effectiveness of the medicinal materials, and guarantees high quality and effectiveness of the medicinal materials.
Owner:GUANGZHOU UNIVERSITY OF CHINESE MEDICINE

Radix ranunculi ternati crude polysaccharide and polysaccharide component as well as preparation method of polysaccharide component as well as application of radix ranunculi ternati crude polysaccharide and polysaccharide component in liver protection and immune regulation

The invention relates to radix ranunculi ternati crude polysaccharide and polysaccharide component as well as a preparation method of the polysaccharide component and application of the radix ranunculi ternati crude polysaccharide and the polysaccharide component in liver protection and immune regulation. The radix ranunculi ternati crude polysaccharide is extracted from radix ranunculi ternate root by using a water extraction mode. The radix ranunculi ternati crude polysaccharide is further separated to obtain the polysaccharide component. The experiment shows that the radix ranunculi ternaticrude polysaccharide and the polysaccharide component thereof disclosed by the invention have the advantages that the proliferation and cytokine secretion of mouse spleen cells can be promoted; the proliferation of human hepatocytes is promoted and the damage of a toxic agent to the cells is reduced; the expression of a hepatitis b surface antigen and a core antigen is inhibited; the proliferation of hepatoma cells is inhibited; in addition, the damage caused by ConA to liver and kidneys of mice is also inhibited, so that the radix ranunculi ternati crude polysaccharide and the polysaccharidecomponent can be used for preparing drugs or health food for resisting hepatitis B, liver injury and tumor, protecting liver, promoting hepatocyte regeneration or realizing immune regulation.
Owner:SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M +2

Diabetes mellitus rehabilitation formula

InactiveCN107715091ARegulate the spleenAntipyreticMetabolism disorderChronic hepatitisAbdominal Hernia
The invention provides a diabetic rehabilitation formula, and the technical solution solved by the invention includes, it is prepared from the following raw materials in the weight ratio: Scrophulariaceae, Snow Lotus, Angelica, Pinellia, Poria, Ophiopogon japonicus, lotus seeds, Gorgon fruit, etc. It is made of a combination of flavored medicines; it is used for diabetes, pancreatitis, strengthening the kidney and strengthening the kidney, and internal and external hernia abdominal pain, for chronic hepatitis, cholecystitis, liver cirrhosis (without ascites) and abdominal pain caused by certain intestinal spasms. Snow lotus snow lotus Warm in nature, sweet and bitter in taste, enters the three meridians of liver, spleen and kidney, and regulates the spleen. Angelica nourishes blood, tangerine peel regulates qi, Poria cocos acts as a diuretic, Rhizoma Cyperi regulates qi, and Wuyu acts as an expectorant.
Owner:杨天梅

Traditional Chinese medicine composition for treating pullorum disease and preparation method and application thereof

The invention provides a traditional Chinese medicine composition for treating pullorum disease. The traditional Chinese medicine composition comprises the following components in parts by weight: 160-200 parts of common andrographis herb, 150-190 parts of cordate houttuynia, 120 -150 parts of coptis, 110-140 parts of Radix Astragali, and 100-140 parts of root of large-flowered skullcap. The invention further provides a preparation method and the application of the traditional Chinese medicine composition. According to definition and characteristics of pullorum disease and the principle of syndrome differentiation and treatment of Chinese veterinarian, the traditional Chinese medicine composition provided by the invention is screened, the composition has the effects of clearing heat and removing toxin, purging fire, diminishing swelling and relieving diarrhea, preventing bacteria and eliminating inflammation, invigorating qi and strengthening superficies, improving spleen functions andimproving metabolic capabilities, and the like, in addition, the composition is safe, nontoxic and free of side effect. Treatment tests on pullorum disease at multiple places show that the composition has a treatment rate of 87.15%, the efficiency rate is 87.15%, and the composition has no adverse reactions in the treatment process.
Owner:LANZHOU WEITESEN BIOTECH

A biological detection method for quality evaluation and quality control of heat-clearing and detoxifying traditional Chinese medicines

ActiveCN106591414BGuarantee high quality and effectivenessObjective Quantitative Evaluation MethodMicrobiological testing/measurementMaterial analysisMedicineQuality control
The invention provides a biological detection method used for quality evaluation on and quality control over heat-clearing and detoxifying traditional Chinese medicines. The biological detection method comprises the steps of firstly adopting a method of anti-rabbit erythrocytea condensation outside the body to represent anti influenza virus activity of heat-clearing and detoxifying traditional Chinese medicines, then adopting a method of anti-mouse spleen swelling method inside the body to represent immune anti-inflammatory activity of heat-clearing and detoxifying traditional Chinese medicines, comparatively completely representing activity of anti-pathogenic microorganisms and anti-inflammatory-immune regulation of heat-clearing and detoxifying medicinal materials through the combination of identification experiments inside and outside the body, and identifying the quality of the medicinal materials through a biological evaluation method. The biological detection method used for the quality evaluation on and the quality control over the heat-clearing and detoxifying traditional Chinese medicines provides a more objective quantitative evaluation method for the clinical effectiveness of the medicinal materials, and guarantees high quality and effectiveness of the medicinal materials.
Owner:GUANGZHOU UNIVERSITY OF CHINESE MEDICINE

Test method for expression of Ermiao powder on rheumatoid arthritis inflammation suppression factors

InactiveCN109288911AReduce in quantityHigh expressionAntipyreticAnalgesicsPositive controlCholinergic anti-inflammatory pathway
The invention discloses a test method for expression of Ermiao powder on rheumatoid arthritis inflammation suppression factors. The test materials include: 80 SD rats, normal saline, three doses of Ermiao powder decoction and methotrexate. The method includes: conducting gastric perfusion of normal saline on the 80 SD rats, performing gastric perfusion of the three doses of Ermiao powder decoction, and carrying out gastric perfusion of methotrexate at a dosage of 2.7mg / (kg.week) to obtain a positive control group, performing 1mL / 100g gastric perfusion each time for 15d continuously, collectingblood, conducting killing inspection, establishing a CIA rat model, and observing the spleen coefficient change and joint synovium section pathological change; and detecting the IL-6 and TNF-alpha level change of serum, the IL-6 and TNF-alpha level change of phagocytes, the expression of cholinergic anti-inflammatory pathway key receptor alpha 7nAChR and other indexes to discuss the RA treatmentmechanism. The result of the invention indicates that the Ermiao powder group joint cavity synovial tissue is villiform, stretches into the joint cavity and has few inflammatory cells, and Ermiao powder has a regulation effect on CHRNA7, thus providing a scientific basis for exploring the pharmacological mechanism of Ermiao powder in treatment of rheumatoid arthritis.
Owner:SHANXI UNIV OF CHINESE MEDICINE

Medicine for treating chicken infectious rhinitis and preparation method

The invention provides a medicine for treating infectious rhinitis of chicken. The medicine is prepared from herba schizonepetae, divaricate saposhnikovia roots, radix angelicae, herba leonuri, dark plums, polyporus umbellatus, cocklebur fruits, magnolia flowers, radix platycodi, wrinkled gianthyssop herb, herba eupatorii, mulberry leaves, cordate houttuynia, radix scutellariae, liquorice roots, Trichosanthes kirilowii Maxim, rhizoma cimicifugae, fructus chebulae and liquor-processed coptidis rhizoma. According to the relation between chicken noses and lungs, spleens, guts and kidneys, fundamentally, the lungs and the spleens are warmed, colds are evacuated, the spleens are invigorated, qi is supplemented, and therefore the purposes of relieving exterior syndromes and reducing phlegm, relieving sore throats, relieving stuffy noses and freeing orifices, removing stagnation and removing stasis, subsiding swelling and stopping pain and completely curing infectious rhinitis of chicken and chronic rhinitis and nasosinusitis of chicken are achieved. The medicine is reasonable in formula, the raw materials are easy to obtain, feeding is convenient, the treatment effect is remarkable, effect taking is rapid, and no relapse occurs. Compared with western medicine, no side effect exists, and no residue exists; diseases can be cured after the medicine is eaten by sick chicken, after the medicine is eaten by disease-free chicken, the medicine can achieve the prevention effect, the immunity of chick bodies can be improved, the diseases are resisted, and the chicken are prevented from being infected with diseases; the preparation process is simple, processing is convenient, and industrial production is easy.
Owner:HENAN HUIMIN POULTRY

Application of prescription with effects of tonifying spleen, nourishing healthy energy and eliminating mass in immunological function after chemotherapy

The invention discloses an application of a prescription with the effects of tonifying the spleen, nourishing healthy energy and eliminating mass in preparation of medicines for reducing the immunological function impairment after chemotherapy, which is a new application of the prescription with the effects of tonifying the spleen, nourishing healthy energy and eliminating mass. The prescription with the effects of tonifying the spleen, nourishing healthy energy and eliminating mass is capable of increasing spleen indexes and thymus indexes, improving the phagocytic function of peritoneal macrophages, the activity of NK (natural killer) cells and the reproductive capacity of T cells and reducing the proportion of T-reg cells, therefore, the prescription with the effects of tonifying the spleen, nourishing healthy energy and eliminating mass has a good effect of alleviating the immune impairment caused by chemotherapy and particularly is capable of obviously reducing the immune function impairment after cyclophnosphamide chemotherapy.
Owner:JIANGSU PROVINCIAL HOSPITAL OF TCM

Traditional Chinese medicine composition for treating liver cirrhosis and splenomegaly

The invention discloses a traditional Chinese medicine composition for treating liver cirrhosis and splenomegaly. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 9-11 parts of rhizoma atractylodis, mangnolia officinalis, dried tangerine or orange peels, radix bupleuri, radix paeoniae alba, dianthus superbus, polygonum aviculare and rheum officinale respectively, 5-7 parts of rhizoma sparganii, curcuma zedoary, radix paeoniae rubra, honey-fried licorice roots and immature bitter oranges respectively, 29-31 parts of Chinese yams and 14-16 parts of malt and vinegar processed turtle shells respectively. Due to reasonable proportioning of the traditional Chinese medicine raw materials, and synergetic effects of the components, the composition has a good effect, is capable of nourishing spleens and effectively recovering spleen functions, effectively recovering synthesis, reservation and detoxication functions of livers of patients suffering from liver cirrhosis, improving living quality of the patients and reducing length of stay in hospitals and in-hospital times of the patients, and in addition is free of conspicuous toxicand / or side effects.
Owner:浏阳市中医医院

Traditional Chinese medicinal granules for treating chicken colibacillosis and preparation method for traditional Chinese medicinal granules

The invention relates to traditional Chinese medicinal granules for treating chicken colibacillosis. The traditional Chinese medicinal granules comprise lonicera japonica, cyrtomium rhizome, houttuynia cordata, anemarrhena asphodeloides, portulaca oleracea, gardenia and licorice. The traditional Chinese medicinal granules are prepared according to the following steps: weighing each component according to a proportion, adding water for decoction twice, mixing filtrate, performing concentration under reduced pressure, performing drying and crushing, adding sucrose for granulation, and performing sieving, drying and sieving to obtain the finished products. The traditional Chinese medicinal granules are mixed with water for diseased chickens to take according to a certain proportion when being used, and after the traditional Chinese medicinal granules are continuously used for a period of time, the diseased chickens can be effectively cured, the spirit, appetite and defecation of the diseased chickens are recovered to be normal, and livers, spleens, pericardia and air sacs are recovered to be normal after the diseased chickens are dissected; after the traditional Chinese medicinal granules are used, high efficacy and good effects are achieved, and residues and toxic or side effects are avoided; the traditional Chinese medicinal granules are convenient to transport and use.
Owner:DINGZHENG ANIMAL PHARMA TIANJIN

Pharmaceutical composition for preventing and treating respiratory anaphylactic disease

The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical composition containing traditional Chinese medicinal active components baicalin, icariin and astragaloside IV for preventing and treating respiratory anaphylactic disease. The invention determines the dose range of the traditional Chinese medicinal active components for inhibiting splenic lymphopoiesis of sensitized mice; and proven by further experiments in vitro, compared with single use of baicalin, icariin and astragaloside IV, the pharmaceutical composition provided by the invention has a stronger effect on inhibiting the splenic lymphopoiesis of sensitized mice, and a stronger effect on regulating Th cell differentiation and transformation of corresponding cell factors into the normalstate. The pharmaceutical composition provided by the invention can be used for further preparing a target organ protecting medicament, and preparing a monomer small compound medicament for improvingthe body immunity and preventing and treating respiratory anaphylactic disease.
Owner:AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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