35 results about "Disease spleen" patented technology

The invention discloses an antibacterial peptide which is obtained by being separated from a Holstein cow spleen and has antibacterial activity, namely a Holstein cow spleen-derived antibacterial peptide, wherein an amino acid sequence of the Holstein cow spleen-derived antibacterial peptide is shown in SEQ ID NO.1. The antibacterial peptide disclosed by the invention is separated from a cow spleen, and the spleen is one of immune organs of an animal and participates blood storage and immunologic processes, so that the antibacterial peptide is extremely low in hemolysis ratio; meanwhile, the antibacterial peptide has some safe biological characteristics without toxic or side effect such as broad antibacterial spectrum, speediness in sterilization, high selectivity, no drug resistance, no teratogenic effect and difficulty in formation of accumulative intoxication, is broad in antibacterial spectrum, has efficient antibacterial effect on Gram negative bacteria, Gram positive bacteria and fungi, can be used for preparing medicines used for treating the Gram negative bacterial, Gram positive bacterial or / and fungal infection and also can be used as a feed additive or a food additive.

The invention relates to application of a PDE9A inhibitor in preparation of products for increasing Treg (Regulatory cell) content, drugs for preventing and treating inflammatory bowel diseases as well as health care products, and relates to the field of medicines. The PDE9A inhibitor can improve mucus secretion of a mucous membrane in the intestinal tract with inflammatory bowel diseases, reducesecretion of TNF- alpha, IL-6, IL-17 and IL-12 / IL-23 pro-inflammatory factors, inhibit DC cell differentiation and migration, increase the proportion of Foxp3+Treg cells and promote the movement of CD4+CD25+Treg cells from the spleen and mesenteric lymph nodes into the colon, thereby inhibiting the inflammatory reaction of the intestinal tract and controlling occurrence and development of the diseases. When applied to drugs for preventing and treating inflammatory bowel diseases, the PDE9A inhibitor can effectively prevent, alleviate and treat the inflammatory bowel diseases; and furthermore,the health care products taking the PDE9A inhibitor as an active component can condition the intestinal tracts of patients suffering from inflammatory bowel diseases so as to control occurrence and development of the inflammatory bowel diseases.

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to a medicinal eye patch for treating blurred vision and a preparation method of the medicinal eye patch. The medicinal eye patch consists of an eye patch body with cavities and a traditional Chinese medicinal component putted in the cavities of the eye patch body. The traditional Chinese medicinal component is prepared from the following raw materials in parts by weight: 30 to 50 parts of cape jasmine fruit, 16 to 30 parts of radix et rhizoma rhei, 16 to 30 parts of radix curcumae, 30 to 50parts of rhizoma coptidis, 16 to 30 parts of radix scutellariae, 18 to 35 parts of airpotato yam rhizome, 18 to 35 parts of oriental stephania root, 15 to 30 parts of myrrh, 25 to 40 parts of concha haliotidis, 25 to 40 parts of semen cassiae and 30 to 50 parts of mulberry leaves. The medicinal eye patch has the advantages of reasonable formula, simple pharmacy process, low cost, high penetrationcapability, quick absorption, bacteria resistance, inflammation elimination and obvious effects of promoting circulation and removing stasis. The medicinal eye patch can promote regeneration of bloodvessels in crystals and enables patients with the blurred vision to be cured; in addition, a product is an external pure traditional Chinese medicinal product and is convenient to use, pollution-freeand convenient to carry; besides, a medicine can directly act eye parts without metabolism of spleen and liver of a human body and quickly takes effect without side effects.

The invention relates to sophora flavescens polysaccharide as well as a preparation method thereof and use thereof in liver protection and immune regulation. The sophora flavescens polysaccharide is extracted from sophora flavescens root in a way of water extraction. A polysaccharide component in the sophora flavescens polysaccharide is obtained by means of further separation. Experiments prove that the sophora flavescens polysaccharide and the polysaccharide component thereof can promote mouse spleen cell proliferation and cytokine secretion, promote human hepatocyte proliferation and reducethe damage of chemical agents to cells, inhibit the expression of hepatitis B surface antigen and core antigen, inhibit the proliferation of hepatocarcinoma cells and inhibit the damage, caused by ConA, to the liver and kidney of a mouse, thus being used for preparing immunomodulatory, anti-tumor and anti-hepatic injury drugs.

The invention discloses medicine composition for improving the immune function of a human body and a preparation method of the medicine composition. The medicine composition is prepared from components of raw materials in parts by weight as follows: 8-80 parts of ficus hirta, 5-60 parts of radix angelicae sinensis and 1-30 parts of ganoderma lucidum. Experiments indicate that the medicine composition has the function of improving the immune function of the human body, the influence of the medicine composition on carbon particle clearance indexes, phagocytic indexes, thymus indexes, spleen indexes and other indexes of immunosuppressed mice is higher than that in two-two compatibility group, and results indicate that the components have a synergistic function. Besides, the medicine composition can remarkably reduce the TC and TG level in serum of the mice and has a blood fat reduction function.

The invention provides a biological detection method used for quality evaluation on and quality control over heat-clearing and detoxifying traditional Chinese medicines. The biological detection method comprises the steps of firstly adopting a method of anti-rabbit erythrocytea condensation outside the body to represent anti influenza virus activity of heat-clearing and detoxifying traditional Chinese medicines, then adopting a method of anti-mouse spleen swelling method inside the body to represent immune anti-inflammatory activity of heat-clearing and detoxifying traditional Chinese medicines, comparatively completely representing activity of anti-pathogenic microorganisms and anti-inflammatory-immune regulation of heat-clearing and detoxifying medicinal materials through the combination of identification experiments inside and outside the body, and identifying the quality of the medicinal materials through a biological evaluation method. The biological detection method used for the quality evaluation on and the quality control over the heat-clearing and detoxifying traditional Chinese medicines provides a more objective quantitative evaluation method for the clinical effectiveness of the medicinal materials, and guarantees high quality and effectiveness of the medicinal materials.

The invention provides a medicine for treating infectious rhinitis of chicken. The medicine is prepared from herba schizonepetae, divaricate saposhnikovia roots, radix angelicae, herba leonuri, dark plums, polyporus umbellatus, cocklebur fruits, magnolia flowers, radix platycodi, wrinkled gianthyssop herb, herba eupatorii, mulberry leaves, cordate houttuynia, radix scutellariae, liquorice roots, Trichosanthes kirilowii Maxim, rhizoma cimicifugae, fructus chebulae and liquor-processed coptidis rhizoma. According to the relation between chicken noses and lungs, spleens, guts and kidneys, fundamentally, the lungs and the spleens are warmed, colds are evacuated, the spleens are invigorated, qi is supplemented, and therefore the purposes of relieving exterior syndromes and reducing phlegm, relieving sore throats, relieving stuffy noses and freeing orifices, removing stagnation and removing stasis, subsiding swelling and stopping pain and completely curing infectious rhinitis of chicken and chronic rhinitis and nasosinusitis of chicken are achieved. The medicine is reasonable in formula, the raw materials are easy to obtain, feeding is convenient, the treatment effect is remarkable, effect taking is rapid, and no relapse occurs. Compared with western medicine, no side effect exists, and no residue exists; diseases can be cured after the medicine is eaten by sick chicken, after the medicine is eaten by disease-free chicken, the medicine can achieve the prevention effect, the immunity of chick bodies can be improved, the diseases are resisted, and the chicken are prevented from being infected with diseases; the preparation process is simple, processing is convenient, and industrial production is easy.

The invention discloses an application of a prescription with the effects of tonifying the spleen, nourishing healthy energy and eliminating mass in preparation of medicines for reducing the immunological function impairment after chemotherapy, which is a new application of the prescription with the effects of tonifying the spleen, nourishing healthy energy and eliminating mass. The prescription with the effects of tonifying the spleen, nourishing healthy energy and eliminating mass is capable of increasing spleen indexes and thymus indexes, improving the phagocytic function of peritoneal macrophages, the activity of NK (natural killer) cells and the reproductive capacity of T cells and reducing the proportion of T-reg cells, therefore, the prescription with the effects of tonifying the spleen, nourishing healthy energy and eliminating mass has a good effect of alleviating the immune impairment caused by chemotherapy and particularly is capable of obviously reducing the immune function impairment after cyclophnosphamide chemotherapy.

The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical composition containing traditional Chinese medicinal active components baicalin, icariin and astragaloside IV for preventing and treating respiratory anaphylactic disease. The invention determines the dose range of the traditional Chinese medicinal active components for inhibiting splenic lymphopoiesis of sensitized mice; and proven by further experiments in vitro, compared with single use of baicalin, icariin and astragaloside IV, the pharmaceutical composition provided by the invention has a stronger effect on inhibiting the splenic lymphopoiesis of sensitized mice, and a stronger effect on regulating Th cell differentiation and transformation of corresponding cell factors into the normalstate. The pharmaceutical composition provided by the invention can be used for further preparing a target organ protecting medicament, and preparing a monomer small compound medicament for improvingthe body immunity and preventing and treating respiratory anaphylactic disease.