35 results about "Disease spleen" patented technology

The invention relates to application of a PDE9A inhibitor in preparation of products for increasing Treg (Regulatory cell) content, drugs for preventing and treating inflammatory bowel diseases as well as health care products, and relates to the field of medicines. The PDE9A inhibitor can improve mucus secretion of a mucous membrane in the intestinal tract with inflammatory bowel diseases, reducesecretion of TNF- alpha, IL-6, IL-17 and IL-12 / IL-23 pro-inflammatory factors, inhibit DC cell differentiation and migration, increase the proportion of Foxp3+Treg cells and promote the movement of CD4+CD25+Treg cells from the spleen and mesenteric lymph nodes into the colon, thereby inhibiting the inflammatory reaction of the intestinal tract and controlling occurrence and development of the diseases. When applied to drugs for preventing and treating inflammatory bowel diseases, the PDE9A inhibitor can effectively prevent, alleviate and treat the inflammatory bowel diseases; and furthermore,the health care products taking the PDE9A inhibitor as an active component can condition the intestinal tracts of patients suffering from inflammatory bowel diseases so as to control occurrence and development of the inflammatory bowel diseases.

The invention provides a biological detection method used for quality evaluation on and quality control over heat-clearing and detoxifying traditional Chinese medicines. The biological detection method comprises the steps of firstly adopting a method of anti-rabbit erythrocytea condensation outside the body to represent anti influenza virus activity of heat-clearing and detoxifying traditional Chinese medicines, then adopting a method of anti-mouse spleen swelling method inside the body to represent immune anti-inflammatory activity of heat-clearing and detoxifying traditional Chinese medicines, comparatively completely representing activity of anti-pathogenic microorganisms and anti-inflammatory-immune regulation of heat-clearing and detoxifying medicinal materials through the combination of identification experiments inside and outside the body, and identifying the quality of the medicinal materials through a biological evaluation method. The biological detection method used for the quality evaluation on and the quality control over the heat-clearing and detoxifying traditional Chinese medicines provides a more objective quantitative evaluation method for the clinical effectiveness of the medicinal materials, and guarantees high quality and effectiveness of the medicinal materials.

The invention provides a medicine for treating infectious rhinitis of chicken. The medicine is prepared from herba schizonepetae, divaricate saposhnikovia roots, radix angelicae, herba leonuri, dark plums, polyporus umbellatus, cocklebur fruits, magnolia flowers, radix platycodi, wrinkled gianthyssop herb, herba eupatorii, mulberry leaves, cordate houttuynia, radix scutellariae, liquorice roots, Trichosanthes kirilowii Maxim, rhizoma cimicifugae, fructus chebulae and liquor-processed coptidis rhizoma. According to the relation between chicken noses and lungs, spleens, guts and kidneys, fundamentally, the lungs and the spleens are warmed, colds are evacuated, the spleens are invigorated, qi is supplemented, and therefore the purposes of relieving exterior syndromes and reducing phlegm, relieving sore throats, relieving stuffy noses and freeing orifices, removing stagnation and removing stasis, subsiding swelling and stopping pain and completely curing infectious rhinitis of chicken and chronic rhinitis and nasosinusitis of chicken are achieved. The medicine is reasonable in formula, the raw materials are easy to obtain, feeding is convenient, the treatment effect is remarkable, effect taking is rapid, and no relapse occurs. Compared with western medicine, no side effect exists, and no residue exists; diseases can be cured after the medicine is eaten by sick chicken, after the medicine is eaten by disease-free chicken, the medicine can achieve the prevention effect, the immunity of chick bodies can be improved, the diseases are resisted, and the chicken are prevented from being infected with diseases; the preparation process is simple, processing is convenient, and industrial production is easy.

The invention discloses an application of a prescription with the effects of tonifying the spleen, nourishing healthy energy and eliminating mass in preparation of medicines for reducing the immunological function impairment after chemotherapy, which is a new application of the prescription with the effects of tonifying the spleen, nourishing healthy energy and eliminating mass. The prescription with the effects of tonifying the spleen, nourishing healthy energy and eliminating mass is capable of increasing spleen indexes and thymus indexes, improving the phagocytic function of peritoneal macrophages, the activity of NK (natural killer) cells and the reproductive capacity of T cells and reducing the proportion of T-reg cells, therefore, the prescription with the effects of tonifying the spleen, nourishing healthy energy and eliminating mass has a good effect of alleviating the immune impairment caused by chemotherapy and particularly is capable of obviously reducing the immune function impairment after cyclophnosphamide chemotherapy.

The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical composition containing traditional Chinese medicinal active components baicalin, icariin and astragaloside IV for preventing and treating respiratory anaphylactic disease. The invention determines the dose range of the traditional Chinese medicinal active components for inhibiting splenic lymphopoiesis of sensitized mice; and proven by further experiments in vitro, compared with single use of baicalin, icariin and astragaloside IV, the pharmaceutical composition provided by the invention has a stronger effect on inhibiting the splenic lymphopoiesis of sensitized mice, and a stronger effect on regulating Th cell differentiation and transformation of corresponding cell factors into the normalstate. The pharmaceutical composition provided by the invention can be used for further preparing a target organ protecting medicament, and preparing a monomer small compound medicament for improvingthe body immunity and preventing and treating respiratory anaphylactic disease.