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132 results about "Smallest blood vessel" patented technology
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Quick Answer. The smallest blood vessels in the human body are capillaries, which connect arteries and veins. Capillaries can be as small as 5 micrometers wide.
Surgical clip applier with remote operation
A surgical clip applier for use in closing wounds under the microscope in small blood vessels modifies a well-known clip applier system to make more steady and reliable the application of very small clips during surgery on a scale of vessel size of 2 mm in external diameter and smaller. The known device is modified internally so as to be capable of receiving a flexible remote actuation device which can be a cable release such as used for a camera shutter, or which can be a flexible hydraulic or pneumatic line as a force-transmitting device. Thus, the surgeon can hold the clip applier very steadily at the site desired without contracting any intrinsic muscles while the cable release is depressed by another person, or with the surgeon's other hand, or with a foot pedal.
Owner:BUNCKE HARRY J
Method and apparatus for allowing blood flow through an occluded vessel
A device arranged to sustain and / or provide at least partial patency of a small blood vessel exhibiting an occlusion, the device constituted of a tubular body expandable from a first small diameter state for manipulation to, and through, the occlusion of the small blood vessel and a second large diameter state, the inner dimensions of the second large diameter state being no more than 50% of the diameter of the small blood vessel at the occlusion location, the device presenting a conduit for blood flow through the occlusion when in the large diameter state. In one embodiment the small blood vessel is an intracranial blood vessel.
Owner:PERFLOW MEDICAL
Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders
InactiveUS7691121B2Prevent and minimize severityEasy extractionStentsDilatorsThrombosis embolismThromboembolic disorder
Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may included a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.
Owner:MICROVENTION INC
An attention mechanism U-shaped densely connected retinal blood vessel segmentation method
ActiveCN109448006AImprove performanceExtract accurate and moreImage enhancementImage analysisData setNetwork model
The invention relates to an attention mechanism U-shaped densely connected retinal (a novel retinal blood vessel segmentation method fusing DenseNet and Attention U-net network) blood vessel segmentation method, comprising the steps of retinal blood vessel image preprocessing and constructing a retinal blood vessel segmentation model. The method of the invention can effectively solve the problemsthat adjacent blood vessels are easy to connect, the micro blood vessels are too wide, the small blood vessels are easy to break, the blood vessel intersection is insufficient in segmentation, the image noise is too sensitive, the gray value of the object and the background is crossed, the optic disc and the lesion focus are missegmented, and the like. The method of the invention integrates a plurality of network models under the condition of low complexity, the excellent segmentation results are obtained on DRIVE dataset, the accuracy and sensitivity are 96.95% and 85.94%, respectively, whichare about 0.59% and 7.92% higher than those published in the latest literature.
Owner:JIANGXI UNIV OF SCI & TECH
Nf-hev compositions and methods of use
InactiveUS20070042978A1Improve inflammationReduce adhesionAntipyreticGenetic material ingredientsPolynucleotideBlood vessel
Aspects of the present invention relate to NF-HEV nuclear factor genes and polypeptides. Other aspects related to the use of NF-HEV nuclear factor genes and polypeptides. Other aspects related to the use of NF-HEV nuclear factor polynucleotides and polypeptides expressed in endothelial cells from chronically inflamed tissues, particularly in high endothelial venules endothelial cells (HEVECs) and endothelial cells from HEV-like vessels and small blood vessels, in connection with rheumatoid arthritis and Crohn's disease. Aspects of the invention also relates to drug screening assays for identifying compounds capable of modulating NF-HEV activity, wherein such compounds can be used in inhibiting or preventing chronic inflammation.
Owner:GIRARD JEAN PHILIPPE +6
Preventing and/or treating cardiovascular disease and/or associated heart failure
Methods are provided for reducing copper values for, by way of example, treating, preventing or ameliorating tissue damage such as, for example, tissue damage that may be caused by (i) disorders of the heart muscle (for example, cardiomyopathy or myocarditis) such as idiopathic cardiomyopathy, metabolic cardiomyopathy which includes diabetic cardiomyopathy, alcoholic cardiomyopathy, drug-induced cardiomyopathy, ischemic cardiomyopathy, and hypertensive cardiomyopathy, (ii) atheromatous disorders of the major blood vessels (macrovascular disease) such as the aorta, the coronary arteries, the carotid arteries, the cerebrovascular arteries, the renal arteries, the iliac arteries, the femoral arteries, and the popliteal arteries, (iii) toxic, drug-induced, and metabolic (including hypertensive and / or diabetic disorders of small blood vessels (microvascular disease) such as the retinal arterioles, the glomerular arterioles, the vasa nervorum, cardiac arterioles, and associated capillary beds of the eye, the kidney, the heart, and the central and peripheral nervous systems, (iv) plaque rupture of atheromatous lesions of major blood vessels such as the aorta, the coronary arteries, the carotid arteries, the cerebrovascular arteries, the renal arteries, the iliac arteries, the fermoral arteries and the popliteal arteries, (v) diabetes or the complications of diabetes.
Owner:PHILERA NEW ZEALAND +1
Retinal fundus vessel segmentation method based on deep multi-scale attention convolutional neural network
ActiveCN112102283ADiversity guaranteedPrevent fit phenomenonImage enhancementImage analysisData setRetina
The invention provides a retinal fundus vessel segmentation method based on a deep multi-scale attention convolutional neural network. An internationally disclosed retinal fundus vessel data set DRIVEis adopted to perform validity verification: firstly, dividing the retinal fundus vessel data set DRIVE into a training set and a test set, and adjusting the picture size to 512*512 pixels; then, enabling the training set to be subjected to four random preprocessing links to achieve a data enhancement effect; designing a model structure of the deep multi-scale attention convolutional neural network, and inputting the processed training set into the model for training; and finally, inputting the test set into the trained network, and testing the model performance. The main innovation point ofthe method is that a double attention module is designed, so that the whole model pays more attention to segmentation of small blood vessels; and a multi-scale feature fusion module is designed, so that the global feature extraction capability of the whole model on the segmented image is stronger. The segmentation accuracy of the model on a DRIVE data set is 96.87%, the sensitivity is 79.45%, thespecificity is 98.57, and the method is superior to classical UNet and an existing most advanced segmentation method.
Owner:BEIHANG UNIV
Device for crushing and taking out thrombus
The invention discloses a device for crushing and taking-off thrombus. The device comprises a conducting wire, a crossing mesh, a strainer, a draught device, a multi ball bag conduct pipe and a casing conduct pipe. A plurality of ball bags are arranged in series on the soft part of the far end of the multi ball bag conduct pipe; the crossing mesh and the strainer are sleeved through compression on the far end of the ball bag conduct pipe and covered on the ball bags, the ball bags are filled, the crossing mesh and the strainer are pulled off, and the thrombus or other emboli in the small blood vessel is crushed and taken off.
Owner:朱正兵
Ultrasound-mediated drug delivery
InactiveUS20050283110A1Quick cureImproves transdermal penetrationElectrotherapySurgerySexual impotenceTopical treatment
Methods and apparatus are disclosed for treating physiological problems, and for providing rapid, efficacious transdermal treatment, for example, of muscle sprains, erectile dysfunction, or baldness, without requiring the use of needles or other invasive interventions. A topical therapeutic agent and ultrasound energy are applied to a tissue surface, e.g., the skin, such that the ultrasound enhances transdermal penetration of the agent. The invention is especially useful in localized delivery of a controlled dosage of a therapeutic agent to the small blood vessels and capillaries beneath the skin's surface.
Owner:TECHNION RES & DEV FOUND LTD
Translucent intensity projection imaging
InactiveUS7020318B2Eliminate bad effectsPromote resultsSurgeryCharacter and pattern recognitionImage contrastProjection image
MR imaging produces a projection image showing better image contrast between small blood vessels and background than traditional net intensity projection (NIP) images but more visual clues to vessel depth than traditional maximum intensity projection (MIP) images.
Owner:ADVANCED MRI TECH
Dual Diameter Introducer Guide Wire
The present invention is directed to a dual diameter guide wire that is steerable inside the lumen of a patient, and provides greater ability to access small areas such as the interior of a needle, or the interior of a patient's lumen such as small blood vessels, thereby improving access to a patient's body during interventional procedures. The present invention is also directed to medical devices for interventional applications, methods of accessing the interior of a lumen of a patient's body and methods of preparing a guide wire.
Owner:TERUMO MEDICAL CORP
Cerebral aneurysm endovascular plastic repair bracket and conveying device thereof
The invention discloses a cerebral aneurysm endovascular plastic repair bracket and a conveying device thereof, and solves a technical problem of treating small blood vessels and particularly cerebral aneurysm in a human body. The repair bracket is a netlike cylinder which is wove by elastic alloy wires with diameter of 30-50mum followed by heat treatment to form an elasticated net taking a cylinder shape in a free state, two end portions of the netlike cylinder is sparsely wove and a middle portion is closely wove to form a compact section. In the conveying device, a microcatheter is internally provided with a bracket folded in a straight line shape, a guide wire passes through the bracket, two ends of the bracket is connected with the guide wire by a pushing ring, and the bracket is the netlike cylinder. Compared with the prior art, the bracket composed of short diameter and soft alloy wires benefits isolating cerebral arteries bearing an aneurysm from a cerebral aneurysm neck, reducing thrombosis caused by impact of blood in the arteries bearing the aneurysm on the cerebral aneurysm body and separating the cerebral aneurysm body from the arteries bearing the aneurysm, thus the bracket is applicable to treatment of fusiform cerebral aneurysm.
Owner:成正辉
Method for enhancing blood vessels in retinal images based on the directional field
InactiveCN101520888AFilter noiseReduce difficultyImage enhancementEye diagnosticsLow contrastDissection
The invention discloses a method for enhancing blood vessels in retinal images based on the directional field, which includes: step one: the directional field Theta of a retinal image is calculated; step two: the blood vessels in the retinal image are enhanced according to the directional field Theta to obtain the enhanced image of retinal blood vessels; and step three: a Gabor wave filter is used for filtering noise in the enhanced image. The method can effectively enhance small blood vessels with low contrast ratio in the retinal images, which brings great convenience to the subsequent processing of the retinal images. In the invention, normalization processing is carried out to image backgrounds while the blood vessels are enhanced, which effectively overcomes influence of image noise and uneven lightness and saves the single normalization step. The invention has important practical value in the fields of dissection of blood vessels in the retinal and heart images and other fields.
Owner:INST OF AUTOMATION CHINESE ACAD OF SCI
Fundus blood vessel segmentation method based on branch attention and multi-model fusion
ActiveCN111047613AImprove segmentationImprove Segmentation AccuracyImage enhancementImage analysisMedicineComputer vision
The invention relates to a CT image organ segmentation method based on convolutional neural network multi-dimensional fusion. The method comprises the steps of S1, training a Unet++ model through weights, training data and label data which are obtained through label calculation by means of an attention loss function; S2, training the Unet++ model by utilizing the training data, the label and a binary cross entropy loss function; S3, respectively obtaining two different segmentation results by utilizing the two obtained trained Unet++ models and the to-be-segmented data; and S4, fusing the twodifferent segmentation results. According to the method, the problem that some small blood vessels cannot be well segmented in the blood vessel segmentation problem of the fundus image is solved, so that the segmentation accuracy is improved.
Owner:北京小白世纪网络科技有限公司
Method for preparing aqueous gel/nano hydroxyapatite composite scaffold for hard tissue repair
The invention belongs to the field of bio-medicinal material science, and particularly relates to a method for preparing an aqueous gel / nano hydroxyapatite composite scaffold for hard tissue repair. The method comprises the following steps of: preparing a small blood vessel by an electrostatic spinning method; preparing a degradable three-dimensional scaffold material taking the small blood vessel as a reserved passage inner wall by using a hot pressing / salting-out method; injecting injectable super-molecular aqueous gel prepared from cyclodextrin, tri-block polymer and nano hydroxyapatite into the reserved passage; and soaking the obtained scaffold into growth factor culture liquid for modification. The composition, property and shape of the prepared scaffold material are more suitable for bone surface blood vessel formation, and new cells and nutrients can enter the inner side of the scaffold through the aqueous gel in the reserved passage to induce bone growth so as to better finish the repair of bone defects. The bone repair effect of the scaffold material is obviously improved compared with other bone repair materials, and the mechanical property, blood vessel function and bone repair function of the scaffold material are obvious compared with common bone repair materials.
Owner:TONGJI UNIV
Embolization microcatheter
ActiveUS20170368306A1Increased local pressureShorten speedMedical devicesCatheterFlow disruptionDistal portion
Microcatheter for delivering a substance (e.g., infusion agent including embolization material and / or contrast enhancing material) in a small blood vessel towards a target bodily part. Includes a single lumen surrounded by tubular wall having outer diameter and opened at both ends; tubular wall proximal portion is connectable to a pressure source and reservoir containing infusion agent, and tubular wall distal portion ends with a tip; the tubular wall distal portion includes an infusion agent flow disruption section configured to disrupt passage therethrough of incoming retrograded flow of infusion agent, during continuous delivery of infusion suspension from the reservoir to the tip. Disclosed are methods using the microcatheter for performing local embolization in a small blood vessel feeding a (for example, cancerous) target bodily part, and for delivering infusion agent in a small blood vessel towards such target bodily part. Also disclosed are devices and methods for filtering non-target infusion agent.
Owner:ACCURATE MEDICAL THERAPEUTICS LTD
Electroactive polymer-based flexing access port
Methods and devices are disclosed for providing access through tissue to a surgical site, such as anatomical cavities ranging in size from the abdomen to small blood vessels, such as veins and arteries, epidural, pleural and subarachnoid spaces, heart ventricles, as well as spinal and synovial cavities. In one exemplary embodiment, an access port is provided having one or more electrically expandable and contractible actuators that are adapted to change an orientation of the access port.
Owner:ETHICON ENDO SURGERY INC
Preferential vasoconstriction compositions and methods of use
The invention generally relates to compositions and methods for preferential vasoconstriction of smaller blood vessels relative to larger blood vessels. The compositions comprise highly selective alpha-2 adrenergic receptor agonists, at low concentrations, such as below 0.05% weight by volume. The compositions preferably comprise brimonidine. The compositions preferably have pH between about 5.5 and about 6.5.
Owner:EYE THERAPIES
Far end protecting device and its preparing method
InactiveCN1663536ASmall form factorThe procedure is safe and effectiveSurgeryCatheterNiti alloyEngineering
The invention discloses one kind of remote end protector and its preparing method. The technique problem to be solved is that collecting solid particle during operating, permitting the flow of blood, and decreasing outline size of protector. The remote end protector in this invention has filter, which is a basket with netting of contracting radial, setting godet bar along axial line, near end leg of basket with netting connects to godet bar, far end connects to godet head. The preparing method is that: 1. knitting mesh duct with NiTi alloy wire and platinum wire, holding at temperature 450~550deg.C; harnessing spring casing pipe to stainless steel wire or NiTi wire; 2. welding casing pipe and godet head, godet bar and casing pipe together. Compared with existing technique, the filter of remote end protector in this invention is basket with netting that can shrink into transport pipe along radian, decreases outline size of remote end protector, can be used to small blood vessel and serious stenotic pathological changes, brings more safe and efficiency for operation, particularly fits conveying to far end of target blood vessel by duct.
Owner:STARWAY MEDICAL TECH
Catheter of composite structure
The invention discloses a catheter of composite structure. The catheter comprises a high-molecular pipe on the outer layer, a tubular woven net or spring net on the middle layer and a smooth inner layer. The high-molecular pipe on the outer layer is made of nylon, nested polyetheramide elastomer, polyurethane or silicone rubber; the wall thickness of the far end of the woven net or spring net on the middle layer is smaller than or equal to the wall thickness of a woven net body or spring net body; the inner layer is made of polytetrafluoroethylene or high-density polyethylene or nested polyetheramide elastomer containing a friction coefficient reducing additive. Compared with a conventional plastic catheter, the composite catheter has the advantages that the same mechanical performance requirement is met, and the wall thickness can be greatly reduced; the passing performance, folding resistance and controllability of the composite catheter are greatly improved, the composite catheter can be pushed to deeper and smaller blood vessels under the same conditions, and the operative successful rate is increased.
Owner:南京普微森医疗科技有限公司
Retinal vessel image segmentation method based on improved UNet + +
ActiveCN112508864AIncrease weightEnhanced Semantic InformationImage enhancementImage analysisContrast levelData set
The invention relates to a retinal vessel image segmentation method based on improved UNet + +, and belongs to the technical field of medical image processing. According to the method, a deep supervision network UNet + + is selected as an image segmentation network model, so that the use efficiency of features is improved; a MultiRes feature extraction module is introduced to improve the feature learning effect of small blood vessels in a low-contrast environment, the generalization ability of a network and the expression ability of a network structure are further improved by coordinating features learned by an image in different scales, and a SeNet channel attention module is added to perform extrusion and excitation operation after feature extraction to improve the accuracy of feature extraction of the small blood vessels in the low-contrast environment. Therefore, the receptive field in the feature extraction stage is enhanced, and the weight of a target related feature channel is improved. The improved UNet + + network model is verified based on a DRIVE retina image data set, and compared with an existing model, the evaluation indexes such as the overlapping ratio, the cross-parallel ratio, the accuracy and the sensitivity are improved to a certain extent.
Owner:KUNMING UNIV OF SCI & TECH
Miniature cross stream thrombectomy catheter
InactiveUS7572244B2Minimizes vessel damageHigh trafficMedical devicesFluid jet surgical cuttersJet flowThrombus
Owner:BOSTON SCI LTD
Electroactive polymer-based flexing access port
Methods and devices are disclosed for providing access through tissue to a surgical site, such as anatomical cavities ranging in size from the abdomen to small blood vessels, such as veins and arteries, epidural, pleural and subarachnoid spaces, heart ventricles, as well as spinal and synovial cavities. In one exemplary embodiment, an access port is provided having one or more electrically expandable and contractible actuators that are adapted to change an orientation of the access port.
Owner:ETHICON ENDO SURGERY INC
Application of nano carbon particles in preparing external medicament for curing haemorrhoids and external medicament
ActiveCN101791320AImprove permeabilityRelieve clinical symptomsPowder deliverySuppositories deliveryBULK ACTIVE INGREDIENTMicrocirculation
The invention provides application of nano carbon particles in preparing an external medicament for curing the haemorrhoids and the external medicament. The active ingredients of the external medicament for curing the haemorrhoids are the nano carbon particles of which the particle diameter is between 1 and 100 nm. The nano carbon powder has high permeability and can go deep into the focus position of the haemorrhoids, thereby obviously improving the blood flowing state of the cirsoid blood vessel, and fundamentally solving the problems of local microcirculation and circulation flowing of small blood vessels, therefore, the external medicament not only can alleviate the clinical symptoms of the hemorrhoids, but also can eliminate the causes resulting in the hemorrhoids, thereby effecting a radical cure for the hemorrhoids.
Owner:天津百纳生物技术有限公司
Vessel stent and production method thereof
InactiveCN104720941AIncrease mesh densityReduced risk of ruptureStentsSurgeryLesion siteInsertion stent
A vascular stent and a method for manufacturing same. The vascular stent has a mesh-shaped tubular structure. The mesh-shaped tubular structure is formed by braiding a metal wire and a biodegradable wire. The vascular stent has the following advantages: First, the stent has a thinner wall, facilitating implantation of the vascular stent into a narrower blood vessel and reducing the risk of restenosis after the stent is implanted in a small blood vessel. Secondly, the rejection caused by the presence of foreign bodies in the human body is reduced, and endothelialization of tissues is promoted. Thirdly, the vascular stent is allowed to have a greater mesh density, so that hemodynamics at the lesion site in the blood vessel can be improved after the vascular stent is implanted in the human body.
Owner:MICROPORT NEUROTECH SHANGHAI
Preventing and/or treating cardiovascular disease and/or associated heart failure
Owner:PHILERA NEW ZEALAND
Method for treating skin disorders with xanthophylls
The present invention provides for a method for treating a skin disorder in a mammal inflicted with a skin disorder. The present invention also provides for a method for retarding or reversing the loss of collagen fibers, abnormal changes in elastic fibers, or deterioration of small blood vessels in sundamaged mammalian skin. The present invention also provides for a method for exfoliating the skin surface of a mammal. The present invention also provides for a method for treating or preventing acne or a pimple in a mammal in need thereof. The methods include topically administering, to a mammal in need of such treatment, a composition that includes xanthophylls in a nontoxic amount, effective to treat the skin disorder.
Owner:NU TEIN
Polymer functional nonwoven fabric
InactiveCN105365291AImprove microcirculationRegulate pHSynthetic resin layered productsClothingsFar infraredNonwoven fabric
The present invention provides a polymer functional nonwoven fabric. The nonwoven fabric comprises a flax fiber layer, an upper polypropylene layer, and a bamboo charcoal magnetic fiber layer, wherein the flax fiber layer is located between the upper polypropylene layer and the bamboo charcoal magnetic fiber layer, a lower polypropylene layer is arranged below the bamboo charcoal magnetic fiber layer, and a nanometer titania photocatalyst layer is arranged above the upper polypropylene layer. The nonwoven fabric provided by the present invention uses the function of magnetic fiber that far-infrared rays can be released, so that microcirculation of the human body can be effectively improved, the pH value of the human body can be adjusted, electrostatic discharge of the human body can be released, and a healthcare effect is achieved to a certain extent. The structure of novel bamboo charcoal magnetic fiber layer has the advantages of high strength, light weight and the like, the microcirculation is improved, and the small blood vessels are opened. The nonwoven fabric has the functions of beautifying the skin, reducing the fat, preventing the skin pruritus of the elder, sterilizing and protecting the skin, and has air permeability and moisture retainability.
Owner:周坤友
Miniature cross stream thrombectomy catheter
InactiveUS20080275383A1High speedImprove actionFluid jet surgical cuttersMetal working apparatusThrombusBlood vessel
A miniature cross stream thrombectomy catheter useful in small blood vessel thrombectomy procedures. An annulus near the distal end of the miniature cross stream thrombectomy catheter is formed between a hypo-tube and a proximally directed bore of a concentrically aligned flow director whereby jet orifices in the hypo-tube communicate with the annulus to direct jet flows of saline or other fluid around and about the annulus and to be directed proximally from the annulus to pass through one or more outflow orifices and thence to pass through one or more inflow orifices thereby creating an ablation flow therebetween which loosens and carries away thrombotic materials from the walls of a blood vessel.
Owner:BOSTON SCI LTD
Bloodless liver exsector
InactiveCN101019776ACompact structureReduce volumeIncision instrumentsWound drainsLiver tissueEngineering
The bloodless liver exsector has one exsector head, one water control button connected through water pipeline to the exsector head, one main control button connected through wires to the exsector head, one power source with circuit board, one suction tube set in the front end of the exsector head, one suction cap covering the front end of the exsector bar and communicated with the suction tube and one flushing tube. During operation, the suction cap with negative pressure sucks out the liquid and other rabbish in the operational view field, and the liver exsector exsects liver tissue while blocking small blood vessels and coagulating electrically for hemostasis. The operation process has clear view field and is safe, and the bloodless liver exsector has compact structure, small size and easy operation.
Owner:THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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