The invention discloses a cargo outer package disinfection device. The whole device is S-shaped, one side of the device is an input end, the other side of the device is an output end, and an input transition bin, an input arc shielding bin, an adjusting bin, a disinfection bin, an output arc shielding bin and an output transition bin are sequentially arranged from the input end to the output end; adjustable quick hasps are arranged on four sides of each bin body and are used for detachably connecting the adjacent bin bodies; and mirror stainless steel is arranged on the inner wall of the disinfection bin, and multiple sets of angle-adjustable pulsed accent light lamps are arranged on the four surfaces in the disinfection bin. According to the device, the adjustable quick hasps are arranged among all the structural bodies, so that the whole device can be quickly disassembled and assembled in a very short time and put into operation again, and the flexibility is extremely high. Besides, black sound absorption cotton is mounted on the arc-shaped inner wall of the S-shaped structure, the arc-shaped inner wall can conduct diffuse reflection on the light, beside, a light absorption material can consume the harmful light, and therefore, the effect of shielding the harmful light is achieved.