The invention discloses a method for measuring the deformation of a large-sized work-piece, which comprises the following steps of: firstly, placing a fixed point; secondly, sticking a deformation point; thirdly, sampling and shooting a picture; fourthly, rebuilding the information of the deformation point; fifthly, combining the coordinates; sixthly, resetting the ID of the deformation point; andseventhly, calculating the deformation quantity. By the operation steps, the invention can measure the direction and size of the three dimensional deformation of the large-size workpiece, which is caused by the applied force load, thermal load, etc. The method has the characteristics of easy operation, no restriction of the size of the workpiece, abundant measurement information, precise and reliable results, high efficiency and non-contact measurement.