The invention relates to a controlled release transdermal patch for preventing and treating cardiovascular and cerebrovascular system diseases, which consists of a protectively layer, a medicine release layer, a medicine storage layer and a back lining layer through being sequentially overlapped, wherein the protectively layer is siliconized anti-sticking paper or a polyethylene film or a siliconized polyester film, the back lining layer is an aluminum foil, an aluminum foil and polyethylene composite film or a polyester composite film, the medicine releasing layer is prepared from 3 to 8 percent of cyclovimbuxine D, 60 to 70 percent of pressure sensitive adhesive substrates, 5 to 10 percent of composite transdermal penetrating agents, 20 to 30 percent of plasticizing agents and 1 to 3 percent of cross-linking agents, the medicine storage layer consists of 8 to 15 percent of the cyclovimbuxine D, 50 to 60 percent of the pressure sensitive adhesive substrates, 1 to 5 percent of composite transdermal penetrating agents, 20 to 30 percent of plasticizing agents and 1 to 3 percent of cross-linking agents. The patch of the invention is prepared by an organic solvent dispersing method, the preparation process is simple, the prepared patch has the exact curative effect, stable quality, high safety and convenient use, and is applicable to the long-time prevention and treatment of the cardiovascular and cerebrovascular diseases.