The invention provides a composite honeycomb sandwich structure for an oversized high-precision single-curved reflection panel. The composite honeycomb sandwich structure comprises three layers of hard aluminum plates, two layers of aluminum honeycomb cores and a sectional material framework for connecting and supporting. A total realization process comprises determination of a panel partitioningscheme, splicing of the three layers of hard aluminum plates, determination of a slotting scheme, calculation of shielding, unfolding of the panel, calculation of nailing height, positioning of the three layers of hard aluminum plates, the panel and the sectional material framework on a high-precision nailing bed, production of a working plate solid mold, pre-stretching and molding of the sectional material framework, notching of the honeycomb cores, adjustment of the nailing bed, layer-by-layer pavement of the sandwich structure and cementing and formation under vacuum negative pressure. Thecomposite honeycomb sandwich structure is applied to engineering, and the formation rigidity and profile precision stability of the oversized high-precision single-curved reflection panel can be effectively improved; a production target of an oversized and single-curvature high-precision, large-rigidity and light-weight reflection panel applicable to a column surface near field is realized.