The invention discloses a building low-toxicity epoxy resin grouting material and a preparation method thereof, and relates to the technical field of grouting materials. The building low-toxicity epoxy resin grouting material comprises the following components in parts by weight: 50-60 parts of bisphenol A epoxy resin, 30-50 parts of a curing agent, 10-20 parts of a diluent, 3-5 parts of a coupling agent, 7-10 parts of a defoaming agent, 60-80 parts of quartz sand, 50-80 parts of slag, 60-80 parts of cement, 10-15 parts of an expanding agent and 80-100 parts of water. According to the invention, the grouting material prepared by the invention has good flowability by adding the diluent, has very good mechanical properties and medium corrosion resistance after being cured, has the characteristics of high strength, high flowability, low toxicity and the like; and due to the mixed addition of cement, quartz sand and slag and the synergistic effect of the curing agent, the coupling agent and the expanding agent, the raw materials in the components are promoted to be fused, the compressive strength, breaking strength, pulling strength, creep resistance and other properties of the grouting material are improved, especially the shrinkage rate of the grouting material is reduced, and various comprehensive properties of the epoxy resin grouting material are improved.