The invention discloses a voltage-regulating variable-frequency hierarchical control ultrasonic plastic welding power supply, which comprises a sampling control unit, a rectifying and DC voltage-regulating unit, a fixed phase-shift angle inversion unit, a matching boosting isolating unit and an ultrasonic transducer. The sampling control unit comprises a microprocessor, a first signal conditioning circuit, a second signal conditioning circuit, a driving circuit, an effective value detection circuit and a phase detection circuit, wherein the first signal conditioning circuit and the driving circuit are connected with the microprocessor; the second signal conditioning circuit is respectively connected with the effective value detection circuit and the phase detection circuit; and the effective value detection circuit and the phase detection circuit are both connected with an AD sampling port of the microprocessor. The voltage-regulating variable-frequency hierarchical control ultrasonic plastic welding power supply has the advantages that output voltage and current waveform THD is small, the voltage-regulating range is wide, large-power ultrasonic welding can be realized, the voltage-regulating or power-regulating response is quick, the voltage ripple is small, the transducer has a small vibration amplitude fluctuation, the frequency tracking precision and the accuracy are high, the electric conversion efficiency is high and the like.