The invention discloses a pharmacy dispensing system and a dispensing method. The pharmacy dispensing system comprises a doctor's order dispensing system, a pharmacy list processing system, a pharmacydispensing system, a plurality of mobile clients, a plurality of pharmaceutical shelves and a plurality of dispensing vehicles. The pharmacy dispensing system comprises a doctor's order dispensing system, a pharmacy list processing system, a pharmacy dispensing system, a plurality of mobile clients, a plurality of pharmacy shelves and a plurality of dispensing vehicles. A medicament list processsystem is arranged in a nurse station of a hospital, and comprises a doctor's order receiving module, a medicament list generate module, a medicament list sending module and a medicament dispensing information receiving module. The pharmacy dispensing system comprises a pharmacy list receiving module, an identity information processing module, a pharmacy list dispensing module, a storage module and a first dispensing information sending module. The mobile client is respectively wirelessly connected with the dispensing system of the pharmacy, and comprises an identity information binding module, a drug list confirmation module, a drug checking module, a second dispensing information sending module and a drug signing module. The invention can distribute medicine to people, can manage performance, can prevent medicine distribution error, can operate paperless, reduce resource consumption and waste, and reduce manpower allocation quantity.