The invention discloses a medical PVC (polyvinyl chloride)) sole material suitable for high-temperature steam sterilization, mainly comprising PVC resin, a plasticizer, an auxiliary plasticizer, a thermal stabilizer, an auxiliary thermal stabilizer, a lubricant, split-film fiber, a compatibilizer, an antibacterial agent and the like. The problems that an existing medical PVC sole material suffers sole yellowing, decreased mechanical performances and softening deformation after being subjected to high-temperature steam sterilization are solved, and the medical PVC sole material is better in high-temperature stability, folding resistance, tear resistance, wear resistance and size stability; in addition, by adding an antistatic agent, the problem that high-temperature steam sterilized PVC shoe material is prone to static generation is solved; the invention also provides a production method of the medical PVC sole material suitable for high-temperature steam sterilization, comprising: preparation of a composite thermal stabilizer, mixing of resin and an aid, extrusion granulating, and injection molding; the production method is simple and easy to industrialize.