The invention discloses a compound pharmaceutical composition for strengthening body resistance and removing toxin, use and feed thereof. The compound pharmaceutical composition is a traditional Chinese medicine extract formed by water decoction and extraction processing of astragalus, Chinese angelica, echinacea, Poria cocos, bighead atractylodes rhizome, Radix Isatidis, Folium Isatidis, Herba Epimedii and licorice, can be added into feed directly or further processed into granules, tablets, oral liquid and injection, etc. The compound traditional Chinese medicine pharmaceutical composition is compounded according to the Chinese veterinary drug prescription according to the principle of differentiated treatment of symptoms, repeated clinical tests prove that the compound pharmaceutical composition has the efficacy of strengthening vital qi, consolidating the basis, and removing pathogenic evils, can strengthen the body immunity of cultured animals and improve the disease resistance of cultured animals. The compound traditional Chinese medicine pharmaceutical composition provided by the invention has the advantages of simple production process, convenient use, significant effect, no residue, green and environmental protection, is conducive to mass prevention and mass treatment of cultured animals, and is beneficial to prevention and control of animal epidemic diseases.