The invention provides a hybrid electric vehicle, a motor driving transmission system and a vibration reduction mechanism of the system. A motor driving transmission mechanism comprises a middle shaft, a rotor, a first supporting part, a second supporting part and a vibration reduction element. The first supporting part is used for being connected with the middle shaft, and the second supporting element is used for being connected with the rotor; the vibration reduction element is connected between the first supporting part and the second supporting part and made of a damping material. In the motor driving transmission system, the first supporting part in the vibration reduction mechanism is connected with the rotor of a motor, and the second supporting part is fixedly connected with the middle shaft of the motor driving transmission system. By means of the vibration reduction mechanism, the vibration reduction element can well attenuate high-frequency vibration of the motor driving transmission system, the frequency of the high-frequency vibration is attenuated below the normal rotation speed of the motor, the resonance problem caused by high-frequency vibration is effectively reduced, noise generated by resonance can be reduced, human ears are prevented from being harmed, the situation that the motor, a transmission and other parts are damaged due to resonance is also avoided, and the service life of products is prolonged.