33 results about "Terbutaline sulphate" patented technology

The invention relates to a preparation method of terbutaline sulfate, which comprises the following steps: dissolving a compound of formula I or formula II into a solvent A, adding a metal catalyst for catalytic hydrogenation, so as to obtain 5-[2-[(1,1-dimethylethyl)amido]-1-ethoxyl]-1,3-resorcinol; after the reaction is finished, filtering, collecting filter liquor, adding a certain amount of concentrated sulfuric acid in the filter liquor, after stirring is stopped, recycling the solvent A, adding a solvent B into a residue, stirring to separate out a white crystal substance, performing suction filtration, thus obtaining the terbutaline sulfate. According to the method provided by the invention, the treating difficulty after the reaction is greatly reduced, the introduction of water and inorganic salt is avoided, and the product content is high; furthermore, the stability of the terbutaline sulfate is obviously improved by distilling the product under acidic conditions, the catalyst and the reaction solvents are recyclable, so that the environmental protection pressure is greatly reduced.

The invention provides a method for preparing terbutaline sulphate B crystal form. The method comprises: selecting a solvent, dissolving 1-(3,5-dibenzyloxy phenyl)-2-n-tert-butyl aminoethanol into the solvent, removing benzyl groups through hydrogenolysis by a general method, obtaining terbutaline free alkali, and adding sulfuric acid into the terbutaline free alkali to form terbutaline sulphate of crystal form B; or dissolving terbutaline sulphate of non-crystal form B into the solvent, stirring the terbutaline sulphate of the non-crystal form B in the solvent at a certain temperature until the terbutaline sulphate of the non-crystal form B is converted into the terbutaline sulphate B crystal form through dissolution and lixiviation, and reclaiming the leached terbutaline sulphate B crystal form. The method has the advantage of obtaining the terbutaline sulphate B crystal form which has stable chemical and physical properties and meets the requirements of medical preparation.