4results about How to "Good zoom effect" patented technology

The invention discloses a lactic acid bacteria bionic extracellular vesicle as well as a preparation method and application thereof, and belongs to the technical field of medical materials. According to the preparation method of the lactic acid bacteria bionic extracellular vesicles disclosed by the invention, lactic acid bacteria cells are efficiently broken by utilizing a high-pressure homogenization technology, and the lactic acid bacteria bionic extracellular vesicles are separated and purified by adopting differential and ultraspeed centrifugation. The preparation method disclosed by the invention is simple and controllable in process, and large-scale amplification and standardized production are easy to realize; the obtained bionic extracellular vesicles of lactic acid bacteria are higher in yield and uniform in particle size than natural extracellular vesicles, have similar safety to the natural extracellular vesicles of lactic acid bacteria, and can promote immune maturation of dendritic cells and drug delivery carrier activity. The compound can be used as a vaccine adjuvant, an immunopotentiator and a vaccine and nano-drug delivery carrier to be applied to the field of biological medicine.

The invention relates to the field of medicinal chemistry, and particularly discloses a novel TLR8 agonist intermediate as well as a preparation method and application thereof, which are suitable for process development of 4, 6-diaminopyridino [3, 2-d] pyrimidine TLR8 agonists. According to the preparation method, tert-butyl is adopted to replace 2, 4-dimethoxybenzyl to serve as an amino protecting group, so that the crystallization property of the intermediate is remarkably improved, column chromatography is avoided, the cost is reduced, and the process stability is improved. The preparation method of the TLR8 agonist intermediate comprises the steps of reduction, acylating chlorination, coupling, amination and the like, has the advantages of being easy and convenient to operate, high in yield, environmentally friendly and the like, and is particularly suitable for industrial production.

The application provides a continuous synthesis method of a triamide compound and application thereof, relates to the technical field of organic synthesis, and comprises the following steps: (a) feeding ketoxime and a solvent into a micro-channel reactor to generate a hydrogenation reaction, so as to obtain an amine intermediate; and (b) feeding the amine intermediate, an acid chloride and an acid binding agent into the micro-channel reactor to generate an amidation reaction, so as to obtain the triamide compound. The application has the advantages of stable heat release, accurate residence time control, safe and reliable operation, and good amplification performance. Compared with a traditional method, the production efficiency of the application is higher, the production cost is greatly reduced, the low-cost and high-efficiency and large-scale production of the triamide nucleating agent can be realized, and the green synthesis and industrial application of the high-performance nucleating agent are facilitated.

The utility model relates to the technical field of signal processing, in particular to an intelligent sensor signal processing circuit, which comprises a signal differential amplification circuit and a signal inverting amplification circuit, the signal differential amplification circuit is composed of resistors R1, R2, R3, R4, R5, R6, R7, R9, R10, R11, R12, R13 and R14, capacitors C1, C2, C3, C5 and C6, a dual-channel operational amplifier U1A, and double diodes D1 and D2, and the signal inverting amplification circuit is composed of resistors R1, R2, R3, R4, R5, R6, R7, R9, R10, R11, R12, R13 and R14, capacitors C1, C2, C3, C5 and C6. The signal inverting amplification circuit is composed of a resistor R8, a resistor R15, a resistor R16, a capacitor C4, a dual-channel operational amplifier U1B and a protection diode T1, the two stages of amplification circuits are arranged, the front half part is the signal differential amplification circuit, the rear half part is the signal inverting amplification circuit, and through signal amplification processing of the front part and the rear part, a better amplification effect can be achieved; the signal amplification effect is more obvious; meanwhile, the input end voltage of the two-channel operational amplifier U1A can be clamped between-12V and + 12V through the double diodes D1 and D2 so as to protect the operational amplifier and prevent the operational amplifier from being burnt out due to overlarge voltage.