The invention discloses an engine anhydrous cooling liquid and a preparation method thereof, wherein the engine anhydrous cooling liquid comprises the following raw materials by the weight percentage:60-70% of propylene glycol, 25-30% of ethylene glycol, 3-4% of 1,2-aminoazophenylene, 1-2% of sodium nitrate, 2-3% of glycerol, 1-2% of triethanolamine, 0.5-1.5% of sodium hydroxide, and 0.1-1% of apigment. The anhydrous cooling liquid has the freezing point lower than -52 DEG C and the boiling point more than 190 DEG C and has a large thermal safe space, so with the use of the product, the anhydrous cooling liquid can maintain a good state for operation, adequate power is maintained, noise is reduced, a water tank does not produce 'boiling', and cylinder score is not generated. With use ofthe anhydrous cooling liquid, zero corrosion can be achieved, no water rust is generated, cleaning and repair are not needed forever, and boiling, cylinder score, water tank blocking, water rust, water scale, corrosion and cavitation corrosion, engine fatigue, nausea, explosive vibration, precombustion, large noise, unstable idle speed, cylinder pressure reduction, insufficient power, oil consumption increase and large exhaust gas emission smoke and other phenomena are thoroughly eliminated.