The present invention relates to instant cuttlefish juice seasoning sauce and a manufacturing method thereof. The cuttlefish juice seasoning sauce comprises: cuttlefish juice, olive oil, butter, onions, garlics, fresh gingers, green chilies, carrots, brandy, crushed black pepper, oyster sauce, wet sweet potato powder and water. The cuttlefish juice seasoning sauce is obtained by the technologies of blending, canning, sterilizing, etc. The cuttlefish juice seasoning sauce is delicate, smooth, and moist in mouthfeel, and easy to accept by people, contains various human body needed nutrients, and more importantly contains the special components having a certain health-care efficacy. The cuttlefish juice sauce is simple and convenient, time-saving, safe and reliable, and can be eaten safely. More importantly, the manufacturing method turns the cuttlefish juice from wastes to treasures, provides a feasible way for the development and utilization of the cuttlefish juice, meets consumers' sensory requirements, achieves health-care desires, improves the added values of the cuttlefish, and creates new social and economic benefits.